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Biomedical subjects

F Komolafe

Publications and source records attributed to F Komolafe.

At least 19 recordsLinked to original sources

Pretreatment urographic evaluation in invasive carcinoma of the cervix uteri.

The urographic findings in 52 patients with histologically proven carcinoma of the cervix were studied. Obstructive changes observed were classified according to the severity of calyceal distension and related to the clinical staging of the disease. Obstructive urographic changes were present in 46% of cases, which is three times as high as reported in Caucasian populations, and the severity correlated significantly with the stage of disease. Urography is advocated as a useful pre and post-treatment index of the progress of cervical treatment.

Adult

Tuberculous pathological fracture of the femur in a 15-year-old boy.

A case is presented of pathological fracture of the distal left femur in a 15-year-old boy with tuberculosis of the knee and involvement of the lower femur. Pathological fracture following tuberculosis of bone is exceedingly rare and prompts the report of this case.

Adolescent

Severe strongyloidiasis presenting as occult gastro-intestinal tract malignancy.

A 38-year-old man presented with severe loss of weight, diarrhoea alternating with constipation and blood in the stool. Clinically, colonic malignancy was suspected, but this was not confirmed. Fresh stool contained numerous larvae of Strongyloides stercoralis. The patient responded promptly to levamisole, with cessation of symptoms and rapid weight gain.

Adult

Transient gas-filled appendix developing during excretory urography.

Gas-filled appendix is well recognized in association with appendicitis, and in acute abdominal conditions associated with bowel distension. 3 patients who developed gas-filled appendix in the course of excretory urography are reported. The phenomenom is thought to result from the reported property of ionic contrast materials to produce anticholinesterase activity and histamine release, either or both of which could produce increased bowel tone and consequent displacement of cecal gas into the appendix.

Adolescent

Calcinosis universalis associated with tuberculosis.

A 12-year-old girl with clinical evidence of abdominal tuberculosis also had a widespread soft tissue calcification termed calcinosis universalis. Despite antituberculous therapy the patient died and autopsy confirmed tuberculous peritonitis. No cause could be found for the soft tissue calcification. The co-existence of the two diseases is probably incidental.

Abdomen

Hydrolethalus syndrome in consecutive African siblings.

Hydrolethalus syndrome may comprise mainly hydrocephalus, polydactyly, micrognathia, congenital cardiac and respiratory anomalies and uniform lethality. It was recently described in Finland, with a suggestion that it might be one of the "Finnish" diseases [4]. We report two cases of this syndrome in consecutive siblings of a Nigerian couple. In addition, we describe associated healing fractures of the long bones, a feature not mentioned in the original report, apparently because those cases were not subjected to post-partum radiography.

Adult

Air esophagogram: a frequent observation in goiters.

Air esophagograms have been described in normal individuals and in association with esophageal disease or respiratory distress. In a study of neck radiographs in 160 patients with goiter, air esophagograms were observed in 24 (15%). The continuous irritation of the enlarged thyroid on the trachea is thought to excite intermittent aerophagy, and accounts for the frequent demonstration of air within the esophagus.

Aerophagy

Multiple staphylococcal pneumatoceles in an adult.

A 33-year-old male with staphylococcal pneumonia who presented radiographically with multiple thin-walled pulmonary cavities (pneumatoceles) is reported. The cavities rapidly altered following treatment with antibiotics and the patient clinically improved.

Adult

Cervical spine changes in goitres.

The cervical spine was studied in neck radiographs of 160 unselected patients and in 100 controls. Anterior marginal osteophytes were observed in 37.5% of the goitre patients and in 17% of the controls. Straightening or reversal of cervical lordosis occurred in 29.4% of patients with goitre and only 8% of controls, with none of the control group showing reversal of cervical curvature. The changes are thought to be due to stresses imposed on the cervical spine as a result of a continuous reflex attempt to bend the neck forwards and reduce pressure on the trachea from the enlarged thyroid gland.

Adolescent