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Biomedical subjects

F Kunz

Publications and source records attributed to F Kunz.

At least 37 records · Page 2Linked to original sources
PubMed1983

Clot lipids in ischaemic heart disease.

Total phospholipids (PL) and neutral lipid classes of plasma, of HDL and of clots produced from platelet-rich plasma and also the main coagulation parameters were determined in normal subjects and in patients with acute myocardial infarction (AMI) and with angiographically diagnosed coronary artery disease (CAD). The main plasma and HDL lipid fractions and the coagulation parameters did not differ significantly between the groups. In contrast, in both groups with ischaemic heart disease triglycerides (TG) bound to clots were selectively elevated precluding accidental trapping of lipoproteins in the fibrin network and suggesting an increased binding of TG-rich lipoproteins to clots. These changes in the quantity and quality of platelet-rich clots, resembling platelet-rich thrombi in vivo, might not only increase the volume of the clots, but also inhibit fibrinolytic enzymes from reaching their substrate. This might be significant in the pathogenesis of ischaemic heart disease.

Adult↗
PubMed1983

Studies in a case of Bernard-Soulier syndrome.

In two siblings, brother and sister, with a history of bleeding Bernard-Soulier syndrome was diagnosed: The stronger affected sister showed a high percentage of giant blood platelets, an abnormal platelet spreading test and a defect in ristocetin and bovine fibrinogen-induced platelet aggregation. In addition, the content of platelet ATP, ADP and AMP was increased. As leucocyte counts were consistently decreased in the more seriously affected anaemic sister, repeated cytochemical examinations of the haemopoietic cells were carried out, revealing maturational defects in the whole haemopoietic system. Therapy with tranexamic acid reduced bleeding in the sister and she has not been anaemic since.

Adenine Nucleotides↗
PubMed1983

The system of medical fitness examinations for seamen in the German Democratic Republic.

The presented report describes the system of medical fitness examinations used for all employees of the GDR's transport system, and therefore also for the seafarers serving in the merchant, fishing and technical fleets, since 1979. The novelty in these tests is that, owing to classification of working places and jobs, the requirements and work loads associated with the working places and jobs can be combined with the health and fitness of the seamen so that his fitness for a particular job can be ascertained.

Adult↗
PubMed1981

[Lipid binding in blood clots in acute myocardial infarct].

Lipids of plasma and of clots produced under standardized conditions from platelet poor plasma and from PTT reagent were examined in patients with acute myocardial infarction (AMI) and in normal persons. No differences were found, which excludes a significant influence of fibrinogen, but not of platelets, on clot-lipid binding. The main lipid fractions were therefore also estimated in clots produced from platelet rich native and citrate plasma. These and the individual phospholipid fractions were determined also in the corresponding plasmas and high density lipoproteins (HDL). Plasma of patients with AMI contained more monoglycerides and lecithin but less lysolecithin. This fraction was particularly low in the HDL and corresponded with a decrease of cholesterol esters. Lipid fractions of clots did not differ significantly, whether they were obtained from citrate or native plasma. Clots in AMI contained significantly more triglycerides (TG) suggesting an increased affinity of TG-rich lipoproteins to platelet rich clots. An increased and changed lipid content of clots could inhibit lytic enzymes essential for the removal of clots. HDL cholesterol-esters in AMI were negatively correlated with the main clot lipid fractions.

Adult↗
PubMed1981

[Carcinoma of the kidney and generalised thorotrastosis after retrograde pyelography (author's transl)].

A 70 years old patient is presented who was nephrectomized because of carcinoma of the kidney following retrograde pyelography with Thorotrast in 1940. Despite of local application of the contrast medium thorotrastosis was also seen in liver, spleen and probably in bone marrow. Possible causal connections are discussed. Thorium was identified in the kidney and in the liver with an electron beam microprobe.

Aged↗
PubMed1978

[Postoperative fructose infusion in a case of presumed hereditary fructose intolerance (author's transl)].

Hereditary fructose intolerance (HFI) was diagnosed in a 61 year-old male patient on account of liver dysfunction followed by prolonged shock immediately after the administration of a fructose and lactose infusion postoperatively. The diagnosis of HFI was based on an increased value of fructose, hypoglycaemia, lactic acidosis and diminution of the phosphate level in combination with the typical family history. The patient's children showed a normal reaction to fructose administration. The therapy included glucose, insulin and heparin administration, balance of acidosis and partial exchange of blood, which resulted in improvement in the glucose level, coagulation factors and acidosis, but could not prevent further liver damage and uraemia with a fatal outcome.

Acidosis↗
PubMed1978

Plasma lipids, coagulation factors, and fibrin formation after severe multiple trauma, and in adult respiratory distress syndrome.

Following severe multiple trauma, decreases were observed in a) Free cholesterol, b) Cholesteryl esters, c) Total phospholipids, and d) Lysolecithin. Comparatively slight changes in coagulation parameters did not differ regardless of whether pulmonary complications developed. In contrast, increased fibrin lipid complexing was more closely correlated with clinical data, because: a) Plasmatic lipids, particularly triglycerides complexed with fibrins, were elevated severalfold in patients with adult respiratory distress and fat embolism syndromes when compared with multiple trauma patients without pulmonary complications. This was independent of plasma lipid levels. b) Plasmatic triglycerides complexed with fibrins were significantly higher in patients who died than in those who survived. The considerable changes in the plasma lipid pattern following severe trauma suggest the presence of an abnormal lipoprotein with increased affinity to fibrin, thereby inhibiting fibrinolysis. This might well be one pathogenic mechanism in the development of post-traumatic respiratory distress syndrome.

Adult↗
PubMed1978

[Phospholipids].

Explore the source record for details and available documents.

Animals↗
PubMed1975

[Lactacidaemia and disseminated intravascular coagulation associated with phenformin medication (author's transl)].

A patient with chronic active hepatitis developed vomiting, dyspnoea, tachycardia, diarrhoea and diffuse pains. For several years she had been treated with azathioprine and for a few weeks before admission with phenformin for mild diabetes. Laboratory examination revealed acute disseminated intravascular coagulation and lactacidaemia. Despite intensive treatment the patient died a few hours after admission, the post-mortem examination revealing diffuse pulmonary haemorrhages. The present case report and those published in the literature suggest that phenformin should not be given to diabetics who also have renal or hepatic disease. In any case, if phenformin is given, it should be stopped if hepatic, renal, infectious or thrombotic complications occur. In these cases and those of sudden unexplained deterioration in diabetics, hospitalisation is essential and lactic acid levels should be determined and coagulation tests performed.

Acidosis↗
PubMed1975

[The pattern of phospholipids during the course of delirium tremens (author's transl)].

Plasma phospholipids were examined in patients with delirium tremens in the acute phase of the disease and after recovery. The levels of lysolecithin, phosphatidylinositol, phosphatidylethanolamine, sphingomyelin and the total of phospholipids were decreased in comparison to normals. Phosphatidylethanolamine, phosphatidylinositol and the total phospholipids were diminished in comparison to patients with liver cirrhoses. Only in the plasma of patients with liver cirrhoses with bad prognosis (hepatic coma) similar low levels of total phospholipids were found. It is concluded from these results, that the synthesis of phospholipids is reduced during delirium tremens.

Alcohol Withdrawal Delirium↗