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Biomedical subjects

F Kwong

Publications and source records attributed to F Kwong.

4 recordsLinked to original sources

Acute symptoms secondary to formaldehyde exposure in a pathology resident.

Formaldehyde is ubiquitous and found at work and at home. The National Institute of Occupational Safety and Health (NIOSH) lists fifty-two occupations with substantial formaldehyde exposure. Pathology is one such occupation. This report describes the incapacitating symptomatology that developed from formaldehyde exposure in a pathology resident. Diagnosis and management of formaldehyde hypersensitivity are discussed and the literature reviewed.

Adult

Changes in skin surface patterns with age.

Cyanoacrylate skin surface biopsies from protected and exposed regions were obtained from two age cohorts (20 to 25 vs 68 to 75) and skin surface patterns were studied by light microscopy. The patterns were markedly altered in exposed areas of the older subjects, whereas protected skin showed only slightly altered patterns with aging.

Adult

Resistance to blockade of vasodepressor responses to tolazoline by chlorpheniramine and metiamide in rabbit hindlimb vasculature.

In perfused hindquarters of anesthetized rabbits, metiamide alone and a combination of metiamide and chlorpheniramine failed to modify tolazoline-induced depressor responses, indicating a lack of histamine H1 and H2-receptor involvement. Failure of atropine and propranolol to alter tolazoline responses precludes cholinergic and beta-adrenergic mechanisms. On the other hand, graded pressor responses to histamine were reversed to depressor responses by chlorpheniramine, whereas a combination of chlorpheniramine and metiamide completely abolished the effects of histamine. The latter results confirm that in the rabbit hindlimb vasculature histamine H1 and H2-receptors mediate pressor and depressor responses, respectively.

Acetylcholine