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Biomedical subjects

F L Nobre

Publications and source records attributed to F L Nobre.

11 recordsLinked to original sources
PubMed1999

[Therapy of arterial hypertension with angiotensin receptor blockers].

Angiotensin II antagonists block the actions of angiotensin II by occupying the AT1 receptors. With this blockade there is no bradykinin increase, the angiotensin II synthetized by the cardiac chymase is also blocked, and the AT2 receptor is stimulated (antiproliferative effect). In animal experiments, losartan reverses left ventricular hypertrophy, inhibits myocardial fibrosis and diabetic glomerulosclerosis and significantly protects from vascular cerebral diseases. In humans, the efficacy of the angiotensin II antagonists and that of other antihypertensives is similar and is potentiated by the addition of a thiazide. They are very well tolerated and no important adverse reactions are reported. Losartan decreases insulin resistance, has a very favourable hemodynamic and neurohormonal profile in patients with cardiac insuficiency, reverses proteinuria and has a uricosuric effect. Angiotensin II antagonists are a step forward towards the ideal antihypertensive drugs.

Angiotensin II↗
PubMed1997

[Sheehan's syndrome].

The authors describe a case of Sheehan's syndrome that followed hemorrhagic complications due to late abortion, and emphasise the infrequency of changes in plasma lipid levels in this disease. They report a particular case of hypopituitarism and point out the main concepts of pathophysiology, diagnosis, therapeutics and complications that follow this increasingly rarer condition.

Abdominal Pain↗
PubMed1995

[Nonalcoholic steatohepatitis].

The authors present a case of a nonalcoholic steatohepatitis, with progression to liver cirrhosis in an obese female patient. A review of the literature, possible evolution, and principle pathological processes involved is made. Attention is drawn to obesity as a risk factor in the progression of steatohepatitis and the advantage of performing liver biopsies in selected cases as a fundamental technique of diagnosis.

Biopsy↗
PubMed1995

[Hypertensive crises].

The goal of the accurate treatment of an hypertensive crisis is to reduce the critically elevated blood pressure to a safer level, in an hemodynamic point of view, although not necessarily normal. The authors stress that a prompt and correct diagnosis in distinguishing hypertensive emergencies from urgencies, in understanding its pathophysiology and the knowledge of available drugs is essential for a successful management.

Angina, Unstable↗
PubMed1993

[Biological rhythms in man. Particular aspects in medicine].

The concepts of chronobiology and chronopharmacology have become more and more important in medical practice nowadays. Today, the circadian variation in blood pressure and heart rate as well as in the occurrence of acute cardiovascular disease is quite obvious (ischemia, infarction, stroke and sudden death). However, biological rhythms are also present in episodes of dyspnoea in nocturnal asthma, in hormonal pulses, in the organization of the immunological system and in the processes of cellular proliferation. These acknowledgments have been leading to changes in our therapeutical approaches implying the definition of correct anti-hypertensive and anti-ischemic strategy was well as in the use of xanthins, corticosteroids, immunomodulators and cytostatics.

Biological Clocks↗
PubMedDate not supplied

[Dystrophia myotonica].

The authors present two cases of myotonic dystrophy (Steinert's disease) with cardiac involvement in young adults. They point out the rareness of this disease, the multisystemic involvement and also the diagnostic problems in the absence of the classic clinical picture.

Adult↗