Biomedical subjects

F L Ozer

Publications and source records attributed to F L Ozer.

13 recordsLinked to original sources

PubMed1988

Mortality-lowering effect of systemic corticosteroid therapy in severe tetanus.

In a double-blind therapeutic trial, 32 patients suffering from severe tetanus were given prednisolone and 31 a placebo in addition to standard treatment. Mortality was lower in the prednisolone-treated group (31%) than in the placebo-treated group (55%). The women had more severe symptoms and a higher mortality than the men. The results suggest that the addition of a corticosteroid to standard treatment will lower mortality in tetanus, although meticulous nursing care is still the most important factor in treatment.

Adolescent↗

PubMed1986

The coincidence of glucose-6-phosphate dehydrogenase deficiency and hemoglobin S gene in Cukurova Province, Turkey.

A total of 1,582 subjects from 10 villages of different ethnic populations were screened for glucose-6-phosphate dehydrogenase (G6PD) deficiency (GdB-, Mediterranean variant) and hemoglobin S gene, and the coincidence of both abnormalities was determined. Although the prevalence of both abnormalities was found to be highest in an Eti-Turk group living in the Tarsus area, coincidence was not significant. In a single village of Adana Eti-Turks, however, coincidence was found to be significant, although neither the frequency of G6PD deficiency nor the existence of hemoglobin S gene was highest in that village.

Anemia, Sickle Cell↗

PubMed1984

Parasitic arthritis induced by Strongyloides stercoralis.

A 40-year-old man presented with palpable purpura and symmetrical polyarticular arthritis. Histological examination of the synovial membrane and fluid unexpectedly disclosed Strongyloides stercoralis infestation of the ankle joint.

Adult↗

PubMed1984

Erythrocyte membrane ATPase activity of G6PD-deficient individuals and the effect of primaquine metabolite(s) on membrane ATPase enzymes.

Erythrocyte membrane Na+/K+, Ca2+/Mg2+ and Mg2+ ATPase activities in addition to the calmodulin-activated Ca2+/Mg2+ ATPase enzyme were measured in both G6PD-deficient and normal individuals. Although all three membrane ATPase activities were somewhat higher in the G6PD-deficient erythrocytes, only activated Ca2+/Mg2+ ATPase activity was significantly increased. The effect of primaquine on the membrane ATPases was also compared with other ATPase inhibitors. Primaquine was ineffective on erythrocyte membrane ATPase in-vitro. However, sera containing primaquine metabolite(s) were inhibitory to Ca2+/Mg2+ and Mg2+ ATPase systems of only G6PD-deficient erythrocytes. Other ATPase inhibitors showed a similar inhibitory effect in G6PD-deficient and normal erythrocytes, indicating a specific influence of primaquine on ATPase system in G6PD deficiency. It is suggested that this effect of primaquine may be an additional factor for haemolysis observed in the people with GdB- type of G6PD deficiency among the Mediterranean populations.

Adenosine Triphosphatases↗

PubMed1981

Glucose-6-phosphate dehydrogenase deficiency in Cukurova Province, Turkey.

The prevalence of red cell G6PD deficiency was studied by a fluorescence screening test in 5 different ethnic populations of Cukurova province. Analyses were performed on samples from the parents of each family unit. The frequency of occurrence in the population was calculated using family trees. 4 551 subjects representing 17 225 offspring from 18 villages were screened and a high incidence of G6PD deficiency was found in the Arabic speaking ethnic groups from Adana (10.4%) and Anthiochus regions (8.1%), whereas the deficiency was only 3.1% in Armenians, 0.8% in mixed villages and 0.5% in Turcomans. This study reveals that the high frequency of this deficiency found in some ethnic populations must be taken into account prior to the treatment of malaria with primaquine.

Glucosephosphate Dehydrogenase Deficiency↗

PubMed1974