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Biomedical subjects

F López Rodríguez

Publications and source records attributed to F López Rodríguez.

17 recordsLinked to original sources
PubMed2000

[Usefulness of bone densitometry in the evaluation of primary hyperparathyroidism].

BACKGROUND: In recent years, the clinical profile of primary hyperparathyroidism (PH) is predominantly characterized by mild or asymptomatic forms. In this context, the effects of the PH on bone metabolism reach a growing importance in the adoption of therapeutic decisions. PATIENTS AND METHODS: 116 patients with PH were studied, 95 women (25 premenopausal, 70 postmenopausal) and 21 males. In all cases parathyroidectomy criteria were evaluated. Bone mineral density (BMD) was determined in 71 patients in lumbar spine (LS) and femoral neck by dual-X-Ray absorptiometry (DXA) and the influence of this measurement in the decision of surgical treatment was analyzed. RESULTS: The patients with PH showed a significant reduction of BMD at all sites (p < 0.001) and 71.8% met osteoporosis densitometric criteria. The most frequent parathyroidectomy criteria was the presence of specific clinical manifestations (51.7%) followed by decrease of the BMD in LS (49.3%). The probability of meeting criteria for surgical treatment was significantly higher in patients in which BMD was measured (odds ratio: 3.09 [1.03-9.22]; p = 0.036). CONCLUSIONS: In its current presentation, PH presents a significant decrease of bone mass. The systematic performance of bone densitometry has a decisive influence in its appropriate management.

Absorptiometry, Photon↗
PubMedDate not supplied

[Replacement therapy with protein C for meningococcal sepsis and fulminant purpura in pediatric patients].

Disseminated intravascular coagulation as associated to sepsis contributes to the development of clinical multiple organ failure by extensive thrombosis in microcirculation vessels. This condition commonly manifests itself in severe meningococcal sepsis. On the skin, its clinical manifestation is extensive purpura with necrotic lesions that usually progress to serious distal ischemia and may call for amputation. A common denominator in these events regarding hemostasis is a depletion of so-called natural anticoagulant proteins, particularly protein C. According to clinical observations replacement therapy with human plasma-derived protein C concentrates has been associated with significantly improved clinical outcome in patients with meningococcal sepsis and fulminant purpura. This paper reports a case of acquired protein C deficiency in a girl with meningococcal sepsis, fulminant purpura, disseminated intravascular coagulation, and septic shock. Fresh plasma therapy was intended to increase consumption coagulopathy-depleted coagulation factors and to provide small amounts of protein C. The inability to restore protein C concentrations above 30%, and the presence of severe thrombopenia in the setting of disseminated intravascular coagulation led to the onset of replacement therapy using a human protein C concentrate (Ceprotin), which increased plasma protein C concentrations and contributed to revert the existing hypercoagulability status. Finally, evidence available in the literature regarding fulminant meningococcal sepsis management using human protein C concentrates and recombinant activated protein C is discussed.

Child↗
PubMedDate not supplied

[Intravenous perfusion of 2,6-diisopropylphenol (propofol) in the maintenance of emergency anesthesia].

In the present study, we describe the use of 2,6 diisopropylphenol (propofol) in emergency surgery. Twenty ASA I and II patients underwent intravenous induction with thiopental (group I) and maintenance with a combination of oxygen/nitrous oxide (30/70%) and in other group of similar characteristics, propofol was used as single induction and maintenance hypnotic (group II). In both groups, atracurium besylate and fentanyl were used according to demand. In group II, there was a significant decrease in systolic blood pressure (16%; p less than 0.01) and diastolic blood pressure (12%; p less than 0.01) during induction as well as a lower incidence of side effects and a more progressive and rapid recovery (eye opening: group II = 16.3 +/- 3.3 minutes; group I = 39.7 +/- 6.3 minutes; p less than 0.01). On the basis of these findings, we believe propofol is a good alternative as single intravenous anesthetic for those patients undergoing emergency surgery and have no marked hemodynamic alterations.

Adolescent↗
PubMedDate not supplied

[Iatrogenic hydrothorax after catheterization of the left internal jugular vein].

We report a case of hydrothorax after cannulation of left internal jugular vein that was not detected early. This complication could be due to various factors: first, venous approach from the left side, given its special anatomic arrangement; second, cardiorespiratory dynamics, and head and neck motion on postural changes during the intervention, and third, incorrect fixation of the catheter to the skin. We discuss preventive measures to avoid such complication. Finally, we advise right approach wherever possible as well as routine control of correct placement of the catheter tip by radiographic film with contrast medium.

Catheterization, Central Venous↗
PubMedDate not supplied

[Cardiorespiratory failure caused by delayed dural perforation].

The epidural administration of drugs is today a common approach to chronic pain therapy. Many patients benefit from this therapeutic modality. However, the more extensively this method is used, the bigger are the number of reported complications. In this case we describe a time-delayed dural tap and a secondary respiratory arrest on a patient with an epidural cervical catheter for treatment of a postherpetic neuralgia.

Aged↗