Biomedical subjects

F Löffler

Publications and source records attributed to F Löffler.

35 records · Page 2Linked to original sources

PubMed1985

[Sonographically detectable changes in placental structures in pregnancy. 2. Statistical comparison of the frequency distribution of placenta stages 0-3 newborn infants with a birth weight of 2,500-3,999 grams].

1200 examinations of sonographical demonstrable placental ripeness were done in 552 pregnant women. The frequency of stages 0 to 3 as compared with aid of O. Bunke's confidence intervals. Stage 0 were found frequently until the 30. week of pregnancy, stage 1 between the 21. and 36. gestational week, stage 2 between the 33. and 38. week of pregnancy and stage 3 between the 35. and 40. week. The comparison of the areas of unsharpness several stages possibly may give informations about the period of pregnancy when the stages coincide.

Birth Weight↗

PubMed1985

[Sonographically detectable changes in placental structures in pregnancy. 3. Statistical, comparison of the frequency distribution of placenta stages 0-3 in newborn infants with a birth weight of less than 2,500 grams].

The utilisation of sonographically provable changes of placental structures in 131 pregnant woman (277 examinations) shows in cases with newborn infants with a weight of birth under 2500 gram than the stage 0 is found significant frequent to the 32. week of pregnancy, the stage 1 to the 40. week of pregnancy, the stage 2 between the 29. and 40. week of pregnancy and the stage 3 between the 31. and 40. week of pregnancy. The stages 0, 1 and 2 influence in comparison with the newborn infants with a weight of birth between 2500 gram and 3999 gram not the weight in newborn infants under 2500 gram. The stage 3 will prove frequent in 13,5 times before the 34. week of pregnancy as in the comparison group with normal weight of birth.

Birth Weight↗

PubMed1985

[Thanatophoric dwarfism].

The thanatophoric dwarfism is a relatively rare disease. The course of a pregnancy with this in every case lethal syndrome is demonstrated in one case. The possible ultrasonographic suspected diagnosis is discussed. If the diagnosis is certain termination of pregnancy is indicated.

Cesarean Section↗

PubMed1984

[Sonographic studies of physiologic involution of the uterus in the puerperium].

141 sonographic investigations were performed in a group of 52 patients between the first and eighth day after normal delivery for supervision of physiologic involution of the uterus. There were examined position of the uterus, size of cervix and corpus and thickness of anterior and posterior uterine wall. The results were examined statistically concerning correlations to birth weight of the newborn.

Birth Weight↗

PubMed1983

Tetrodotoxin-sensitive ion channels characterized in glial and neuronal cells from rat brain.

Ion channels were studied in primary neuronal and in primary glial cultures from rat brain by measuring the uptake of guanidinium, an ion that can permeate the Na+ channel. Neuronal cells exhibit a veratridine-stimulated (EC50 30 microM) guanidinium uptake, which is blocked by tetrodotoxin (IC50 30nM). This demonstrates the presence of a voltage-dependent Na+ channel. In glial cells veratridine + scorpion toxin, but not veratridine or scorpion toxin alone can stimulate a tetrodotoxin-sensitive ion uptake, thus indicating a 'silent' Na+ channel in the glial cells. Phentolamine, propranolol and various local anesthetic drugs (e.g. tetracaine, dibucaine) blocked the two different kinds of Na+ channels in the two cell populations investigated.

Anesthetics, Local↗

PubMed1983

Corticotropin peptides and melanotropins elevate the level of adenosine 3':5'-cyclic monophosphate in cultured murine brain cells.

Cell cultures derived from mouse and rat brain and consisting mainly of astroblasts are known to respond to several hormones by increasing or decreasing their intracellular concentration of cyclic AMP. In the present study these cultures were analyzed for their susceptibility to various additional hormonal and other neuroactive compounds. Only the peptides of the corticotropin (ACTH)/melanotropin (MSH) family were found active. Their potency for elevating the intracellular level of cyclic AMP decreases in the sequence (values for the half-maximally stimulating concentrations, EC50, in parentheses) ACTH-(1-24) (10 m) greater than alpha-,beta-MSH (30 nm) greater than ACTH (greater than or equal to 100 nm) gamma-MSH, ACTH-(1-10), -(4-10), -(4-11) (greater than or equal to 0.5 microM). The lack of additivity of the maximal effects of the peptides suggests that they all act at the same receptor. The stimulation exerted by these peptides is partially suppressed by hormones known to inhibit cyclic AMP formation in that culture, i.e., noradrenaline (acting via an alpha-adrenergic receptor), adenosine (acting via an A1 receptor), and somatostatin. It is concluded that the receptors for the ACTH/MSH peptides and the inhibitory hormones are located on the same cells, presumably the astroblasts. The maximal response to ACTH and alpha- and beta-MSH depends strongly on the age of culture. The results are discussed in view of the facts that (1) peptides of the ACTH/MSH family affect behavior and learning in animals, and (2) ACTH and alpha-MSH occur in brain.

Adrenocorticotropic Hormone↗

PubMed1983

[Sonographically evident changes in placental structures in pregnancy. 1].

During the routine prenatal care a sonographical valuation of the placental tissue structure is performed. It could be proved at 657 gravids (1436 examinations) that the placental tissue structure is changing the course of pregnancy. The results were graduated in three stages from 0 to 3. Stage 0 represents the placenta in the first and second trimester and Stage 3 is used for the ripe placenta. The practical use of the placental tissue structure diagnosis is discussed.

Chorion↗

PubMed1982

Parathyrin and calcitonin stimulate cyclic AMP accumulation in cultured murine brain cells.

Despite the key role Ca2+ plays in the nervous system, biochemical actions on neural tissue of the Ca2+-regulating peptide hormones parathyrin and calcitonin were unknown. Until a few years ago only neurons, but not glial cells, were considered as targets for peptide hormones. Our recent observation that peptide hormones do indeed act on glial cells is extended by the present report that these cells respond to the calcaemic peptide hormones parathyrin and calcitonin. In cultured murine brain cells mainly consisting of glioblasts, parathyrin stimulates the accumulation of cyclic AMP. The half-maximal effect is elicited at 30 nM parathyrin. With rat brain cells the effects are three times those observed with mouse brain cells. Calcitonin, which is less potent than parathyrin, elevates the concentration of cyclic AMP only in rat brain cells. If properly occupied, the inhibitory receptors present on the cells lower the increase in the level of cyclic AMP evoked by parathyrin and, to some extent, that elicited by calcitonin. The results suggest that: (i) these or closely related hormones might exert regulatory functions in brain; and (ii) glial cells must be considered in discussions of the targets of the calcaemic and other peptide hormones.

1-Methyl-3-isobutylxanthine↗

PubMed1981