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Biomedical subjects

F Lackner

Publications and source records attributed to F Lackner.

At least 55 records · Page 3Linked to original sources
PubMed1981

The influence of procarbazine (MIH) on the induction of prophage lambda in Escherichia coli K12 and toxic effects on Salmonella typhimurium.

Natulan R (MIH, procarbazine) was tested for its ability to induce prophage lambda in Escherichia coli GY5027. E. coli Gy4015 served as indicator strain. A weak phage-inducing effect was observed at concentrations from 2 to 12 mg/plate in presence of S9 prepared from rats. This effect was found not to be due to the formation of hydrogen peroxide. It was confirmed that, even at the same high concentrations, no mutagenic effect can be detected with the Ames test in strains TA98 and TA100 of S. typhimurium. However, a toxic effect was observed in presence of S9 in S. typhimurium.

Bacteriophage lambda↗
PubMed1980

[Comparison of effects of hydroxyethylstarch (HES 200/0.5) administered pre- and postoperatively in vascular surgery with dextran 40 (60) (author's transl)].

In a randomised study comprising 16 patients undergoing vascular surgery of the lower extremities blood replacement was performed after preinfusion of either 500 ml 10% hydroxyethylstarch (LMW-HES) or 10% dextran 40 (followed by dextran 60 intraoperatively). After infusion of 500 ml within 30 min preoperatively there was a significant rise in PCWP, PAP, RAP and CI accompanied by an increase in blood volume and colloid osmotic pressure, whereas hematocrit fell. No difference between the two plasmasubstitutres was found, prolonged infusion of HES, however, caused a lesser rise in cardiac pressures and blood volume. Overloading of the circulation could be ruled out by ECG, Frank-Starling curves, blood gases, observation of total pulmonary vascular resistance and vascular filtration pressure. The modified haemodilution technique suggested, using preoperative priming without blood drainage and subsequent dilution by blood replacement up to a total amount of 1,500 ml by HES or dextran thus seems to be free of risks and may be recommended. For monitoring purposes during prolonged operations not only filling pressures should serve as a guideline, determination of blood volume and fluid balance being imperative.

Blood Viscosity↗
PubMed1980

[Choice of anaesthesia technique in thoracic endoscopic sympathectomy (author's transl)].

Thoracic endoscopic sympathectomy (TES) is a short surgical procedure used for the treatment of palmar and axillary hyperhidrosis. It involves pneumothorax, the lateral and head up position, and necessitates minimal chest excursions during breathing, so that a special type of anaesthesia is required. In 13 patients two different methods were compared and blood gas analysis as well as circulatory parameters were studied. We therefore propose an anaesthetic method using controlled mechanical ventilation; relaxation; intravenous anaesthesia; at least 1 1 fluid replacement; and careful monitoring.

Adolescent↗
PubMed1978

[Increasing incidence of Serratia marcescens bacteraemia in intensive care patients (author's transl)].

The incidence of serratia marcescens in an intensive care unit was investigated in course of several years. After a trial of Cephalosporin-Gentamycin prophylaxis, infection and death due to serratia rose dramatically. The significance of decreased resistance to infection, hygiene regimes as well as mode of administration of antibiotics is related to selection of this rare microorganism causing septicemia.

Adolescent↗
PubMed1976

[The patient as a source of bacteria in intensive care units: influence of antibiotics and tracheal intubation (author's transl)].

133 patients in an intensive care unit, who prior to admission had not shown any signs of bacterial infection and had not received antibiotic treatment, were assigned to two groups at random. One group received antibiotic prophylaxis with penicillins or cephalosporins (+Pat.), the other group did not receive antibiotics (-Pat.). Staph. aureus was the most frequent facultative pathogen in tracheal secretions and in the environment of "-Pat.". This organism was significantly more frequent in "-Pat." than in "+Pat." in both the tracheal secretions and the environment. Klebsiella spp. outnumbered all other species in "+Pat.". They were significantly more frequent in tracheal secretions of "+Pat." than of "-Pat.". In the first week of hospitalisation marked changes were seen in bacterial flora of tracheal secretions of "+Pat.". Colonization with grammnegative bacteria rose to nearly 100%, the frequency of Staph. aureus diminishing at the same time. Monitoring by contact cultures revealed that gramnegative rods were significantly more numerous in the environment of "+Pat." than of "-Pat.". Matching bacterial strains cultured from tracheal secretions and from the environment of the patients proved that "+Pat. spread significantly higher numbers of their gramnegative bacteria into the environment. The same is true of "-Pat." for Staph. aureus. Intubation had no noticeable effect on the degree of contamination of the surroundings with Staph. aureus. Gramnegative rods were significantly more frequent in tracheal secretions of patients with intubation than in patients without. The same trend was observed for environmental contamination. As the clinical results of this study have shown, antibiotic prophylaxis does not protect patients from infections to the extent expected. Patients, and particularly intubated patients, receiving antibiotic treatment have to be considered as sources of highly resistant gramnegative organisms.

Anti-Bacterial Agents↗
PubMed1976

[Evaluation of exanthemas following high-dosage intravenous penicillin combinations in intensive care].

118 patients of a non specialized intensive care unit have been studied, all of them under high dose bactericidal cover (10 MIU of Na-Penicillin G and 2,0 Ciclacillin q 12 hrs.) for a period of days to 4 weeks. In 17 (14,4%) a skin rash was observed. 10 of these could be studied using special techniques (radial immunodiffusion, passive hemagglutination, RIST and RAST), however in none of these cases there was a hint of the existence of penicillin specific antibodies. In 6 patients also skin tests were performed. There was no immediate type reaction, only twice delayed type reactions occured to Na Pencillin G.6 patients had continuing treatment on spite of the rash and without further steps the effluorescences vanished within 3-6 days. Therefore continuation of the antibiotic therapy in spite of rash along with strict clinical and laboratory monitoring seems to be preferable to a hastened change of antibiotic regime

Adolescent↗
PubMed1976

[Observations on the course of leucocytes in cardiac surgery under acupuncture-analgesia (author's transl)].

In 11 cardiosurgical patients leucocyte and differential counts were made performed during and after surgery. In some cases Lymphocyte transformation and migration inhibitiontest was studied. Comparing cases under conventional neurolept anaesthesia with those who had acupuncture Analgesia (electrostimulation) it appeared that the number of leucocytes was rising significantly higher in the latter, although the total number of lymphocytes remained constant. In lymphocyte transformation and mirgration inhibitiontest the observed decrease seemed to be less pronounced. Because a trial applying acupuncture in healthy persons resulted in no change in the number of leucocytes, it is suggested that the surgical trauma and related catecholamine release might be of importance. No definite result could be obtained.

Acupuncture Therapy↗
PubMed1975

Urinary catecholamine excretion and thyroid hormone blood level in the course of severe acute brain damage.

Urinary catecholamine excretion and thyroid hormone blood level were studied in 16 patients following severe cerebral trauma. Increased excretion rates of epinephrine and norepinephrine were found. There was no significant difference in the catecholamine excretion when compared with generally traumatized patients. The relationships between catecholamine excretion, increased metabolic rates, and negative nitrogen balance indicate that in patients with a midbrain syndrome there exists an additional diencephalic metabolic factor, which leads to a rise in fat oxidation and perpetuation of catabolism. Early high caloric parenteral nutrition seems to inhibit the initial increase of catecholamine excretion and thus protects the body from an unnecessary breakdown of its own reserves. If the course is classified according to neurological stages, it can be shown that patients with a traumatic apallic syndrome in poor condition have a high increase of catecholamine excretion. Secretion of thyroid hormones is not influenced significantly by cerebral trauma.

Adolescent↗
PubMed1975

[The in vitro influence of dehydrobenzperidol (droperidol) on lymphocyte transformation (author's transl)].

Droperidol, an agent which is used in neurolept anaesthesia was tested in vitro for its effect upon the lymphocyte transformation test. Using peripheral blood of healthy volunteers droperidol was added simultaneously with PHA (phytohaemagglutinin) respectively after the lymphocytes had been incubated with PHA already for a period of 47 hours. Lymphocyte transformation was not impeded significantly when the first method was used, when clinically comparable concentrations were administered. When droperidol was added after PHA even lower concentrations caused an inhibition. The significance of these different modes of testing is discussed. It is concluded from these results that droperidol in clinical concentrations as used in Neurolept anaesthesia does not have a distinct and lasting influence upon lymphocyte transformation and thus has no considerable immunosuppressive effects.

Droperidol↗
PubMed1975

[The treatment of respiratory failure in severe chest injury (author's transl)].

The use of artificial ventilation versus conservative treatment in 101 patients with severe chest injuries is reconsidered, because major ventilation therapy carries a high incidence of complications. This technique within the past few years has increasingly been replaced by differentiated conservative respiratory treatment. On the basis of a retrospective study it is concluded that under special conditions even the unstable chest accompanied by respiratory insufficiency may be treated successfully by this technique.

Adolescent↗
PubMed1975

[Administration of glucose 33 p.c. with added high doses of insulin within a scheme of early total parenteral alimentation to patients with shock-related excessive caloric demand (author's transl)].

40 patients, who had been admitted to the ICU in a stage of shock were given glucose 33 p.c. with added high doses of insulin, administered within a scheme of early total parenteral alimentation, along with fat emulsions and aminoacid solutions. It is demonstrated that this type of nutrition is able to improve metabolisation of glucose in a phase of impaired glucose utilisation following shock. The duration of reduced glucose utilisation is 5-10 days during which period increased addition of insulin (24-18 U insulin/50 g glucose) is advisable. After this time the action of endogenous insulin was improved to such an extent that the added insulin could be reduced to 12 U insulin/50 g glucose up to the third week and later (up to 49 days) to 8 U insulin/50 g glucose.

Amino Acids↗