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Biomedical subjects

F Lamprecht

Publications and source records attributed to F Lamprecht.

At least 37 records · Page 2Linked to original sources
PubMed1996

[Economic sequelae of failed treatments of psychosomatic and somato-psychic illnesses].

The search for biotechnical causes of diseases although very successful in many areas fail to account for wide variations of morbidity and mortality. Such search in the most common symptoms, for which our health care system is utilized, falls short of meeting the health needs of a vast number of patients, since only in 16% such causes can be found. This continuing misunderstanding contributes to the tremendous rise in healthcare expenditures without improving the delivered health care. Relatively short lasting psychosocial interventions are shown to have a significant effect in reducing health care seeking behaviour. This is particular demonstrated in somatization disorder. In the last section examples for cost offset effects in outpatient care and in psychosomatic inpatient treatment will be given with remarkable cost savings. Finally recommendations are listed to meet the health needs of the public more sufficiently. Psychosocial factors are shared determinants of health outcomes across diseases, therefore labeled as "Super highways for Disease", must be taken into account to reduce the number of unnecessary diagnostic examinations and unsuccessful treatments, to reduce the length of hospital stay, to increase the survival rate in cancer by increasing the self-management and self-competence, which will finally lead to a tremendous reduction in costs for our health care system.

Cost Savings↗
PubMed1996

[Psychosomatic rehabilitation].

Containing 14,000 beds on wards, the psychosomatic rehabilitation in hospitals has a significant part in the treatment of psychosomatic and somato-psychological diseases where psycho-social parameters play an etiological role. This work may be aggravated by the fact that these diseases are often recognized too late and that the patients are admitted to specialized hospitals in a state of chronic illness. Nevertheless, these hospitals are working with great success especially regarding the reduction of costs in the period after discharge, reduction of the time being incapable to work, in patient days, medication, and medical attendance. Beside these parameters of cost reduction, the success in treatment also contains the improvement of subjective parameters such as satisfaction of living, relationships, and every day life. Psychodiagnostic hints are given for the on time diagnosis of the mentioned disturbances allow an early and adequate treatment.

Activities of Daily Living↗
PubMed1995

[2 sets of monozygotic twins concordant for anorexia nervosa].

The case reports at hand describe the discordant and the common characteristics of two pairs of monozygotic twins, concordant for anorexia nervosa. The resulting test scores of psychometric questionnaires including the Eating Attitudes Test (EAT) and the Eating Disorders Inventory (EDI) are descriptively presented and compared with each other. Finally the psychodynamic and the psychogenetic implications considering biogenetic findings are discussed.

Adult↗
PubMed1994

[Essential hypertension: psychosomatic aspects].

Essential hypertension is a heterogenous disease made up of several still unspecified subgroups. According to the dual theory of hypertension, acquired and genetic factors can lead to vascular muscle defects and increased sympathetic drive, which, either both or each alone, can lead to an increased vascular resistance. Acquired factors can either help a predisposition to become a manifest disease, act by itself to cause a disease or prevent a genetic trait from becoming manifest. Among the acquired factors, we differentiate those lying inside the personality, which means they are early acquired in life and those lying outside of the individual such as job-stress, noise exposure etc. How the external stressors are perceived depends upon the personality make up and the social support system. Within the presented model the Greek word 'crisis' plays an important role, since it characterizes a state in which a decision has to be made. In a situation in which a decision cannot be made in reality or tried out in fantasy life, the organism will activate the autonomic nervous system in a planless fashion, alternating very rapidly between its two branches, with concomitant symptoms of trembling, piloerection, salivation, vomiting, urination, defecation etc. In case this persists for a longer period of time the reciprocity between the two systems may break down, the organism seems to be psychologically immobilized. In the beginning of stress exposure, increased sympathetic nervous system activity is seen as an adaptive response, thereby enabling the individual to cope, but if the attempts to cope meet with constant failure, the stress becomes unbearable. The attitude of giving up which then develops is accompanied by a low level functioning of the sympathetic nervous system. This goes along with an adaptation for the baroreceptor depressor mechanism. As a consequence, any kind of additional stress would not lead to a relieving counterregulation. This might be a small stone within the mosaic of essential hypertension.

Adaptation, Psychological↗
PubMed1992

[Possibilities in clinical quality assurance founded on a basis documentation system and extended evaluation studies].

Although the topic of quality control (QC) has been under discussion at least since the "Health Reform Legislation" (GRG) in almost all areas of the public health system, there is quite often a lack of models for practicability. Even for inpatient medical rehabilitation--at least concerning empirically founded QC-measures suitable methods and instruments have still to be developed. These must be relatively simple and economical to be integrated in the daily routine within a special clinic, if quality control should function. Starting from a broad concept of evaluation, the authors present a practical empirical QC-model for clinics, specifically for psychosomatic rehabilitation, which has been developed and proven for more than five years. To investigate the "programme" of the clinic, or particular program components (e.g. patients, treatments, outcome criteria) with systematically obtained data and analysis, is the main goal of this model. Where statements are replaced by empirically proven data. Aspects of process and outcome quality are considered to be a main task, and transparency is a necessary supposition. This model is particularly based on questionnaire procedures, is two-tracked, e.g. it is composed by continuous data collection ("treatment documentation") on the one hand and by time-restricted and defined studies for programme evaluation on the other. The treatment results represent the true target variable.

Documentation↗
PubMed1989

[Satisfaction with inpatient management. Development of a questionnaire and initial validity studies].

In Germany methodologically reliable procedures to assess patients satisfaction with inpatient health care are almost totally missing. With reference to the well known American CSQ-Questionnaire (Attkisson et al.) a 17-items questionnaire (to assess satisfaction) was developed and presented to a sample of 300 patients undergoing inpatient treatment within a psychosomatic clinic (the rate of responding was about 80%). With a concise form of the questionnaire (Zuf-8, 8 items) an economical and reliable test-instrument is presented in this paper to measure general satisfaction, which also was investigated in regard to item- and factor analysis. This method seems suitable for measuring patient satisfaction with inpatient psychosomatic treatment. The investigated scales of satisfaction show a statistically significant correlation with additionally obtained patient characteristics. This inquiry also suggests that it might be rewarding to pursue the often neglected phenomenon of questionnaires filled out incomplete as an indicator of latent dissatisfaction.

Adult↗
PubMed1986

[Psychosomatic findings in orofacial pain dysfunction syndrome].

Patients with orofacial pain dysfunction syndrome cannot be treated in a satisfactory manner by looking at them with a monocausal, linear analytical point of view in the sense of aristotelian logic. In this interdisciplinary study 10 patients were investigated by dental and functional diagnostic procedures, by psychological testing and by psychoanalytically oriented interview technique. It became evident that only the consideration of psychosomatic aspects during dental practice can bring relief for these patients.

Facial Pain↗
PubMed1979

Responses of plasma renin activity and dopamine-beta-hydroxylase to increased intravascular volume.

Circadian variations of plasma renin activity, plasma dopamine-beta-hydroxylase, and urinary aldosterone excretion were measured in man under conditions of high- and low-sodium intake. Plasma renin activity and urinary aldosterone excretion were maximal at 8 a.m. Plasma DBH shows small, biologically insignificant circadian fluctuations. In three subjects on low-salt diets, the values were lower than those in the same subjects on high-salt diets. Expansion of intravascular volume in supine normal volunteers lowered plasma renin and DBH activity, and also resulted in a significant natriuresis. The decline in DBH activity probably reflects a decrease in its release from autonomic nerve endings and thus demonstrates in man an effect of decreasing autonomic activity.

17-Hydroxycorticosteroids↗
PubMed1977

6-hydroxydopamine destruction of central adrenergic neurones prevents or reverses developing DOCA-salt hypertension in rats.

The role of brain catecholaminergic neurones in the pathogenesis of DOCA-salt hypertension in the rat was investigated by selective depletion of central catecholamines using intraventricular or intracisternal administration of 6-hydroxydopamine (6-OHDA). Only the intraventricular injections prevented the development of hypertension. In addition, intraventricular 6-OHDA reversed the hypertension produced by two weeks but not six weeks of DOCA-salt treatment. The ability of intraventricular injections of 6-OHDA to prevent or reverse DOCA-salt hypertension while intracisternal injections do not, appears to be related to the greater depletion of brain catecholamines produced by the intraventricular injections. Only in the spinal cord and in the locus coeruleus were the norepinephrine contents depleted equally by either injection route. These findings suggest that central catecholaminergic neurones other than those originating in the locus coeruleus or descending in the spinal cord are important in the initiation, but not in the long term maintenance, of DOCA-salt hypertension. The influence of the central catecholamine neurons involved in the development of DOCA-salt hypertension might be mediated neurally via nonadrenergic pathways or hormonally via the brain-pituitary-endocrine system.

Adrenergic Fibers↗
PubMed1977

Epilepsy and schizophrenia: a neurochemical bridge.

This paper reviews some of the evidence in the literature that suggests neurochemical processes by which the regulation of seizure threshold and the onset of schizophrenic-like symptoms are interrelated. For those patients who experience the alternation of seizures and acute psychoses the following working hypothesis is presented: The central dopaminergic synapse is described as a malfunctioning regulatory circuit. Insufficient feedback inhibition or lifting of the setpoint leads to an increased number of occupied receptors. This might cause schizophrenic-like symptoms. Insufficient release of feedback control or lowering of the setpoint leads to a decreased number of occupied receptors. This might increase seizure susceptibility. The neurochemical arguments in support of this hypothesis will be discussed in detail. The localization of the dopaminergic synapses involved in the development of schizophrenic-like symptoms is subject to speculation. The meso-limbic dopaminergic system has to be taken into consideration.

Amphetamine↗
PubMed1977

[Dopaminergic Neurotransmission in Parkinson's syndrome (author's transl)].

More recent electrophysiological and biochemical data dealing with the functioning of the central dopaminergic synapse are reviewed in relationship to Parkinsonian symptomatology. Emphasis is put on the influence of feedback mechanisms involving pre and postsynaptic receptor sites, the dopaminergic-cholinergic imbalance and receptor supersentitivity. Stimulation of the dopamine-sensitive adenylatecyclase proved to be a good indicator of central dopaminergic receptor stimulation. Current therapeutic concepts are discussed in view of their limitations and side-effects.

Adenylyl Cyclases↗
PubMed1976

Serum dopamine-beta-hydroxylase activity in rat during post-natal development.

Rat serum dopamine-beta-hydroxylase (DBH) activity is quite high in the immediate post-natal period reaching peak activity (75 units) at 16 days of age. Activity then decreases rapidly over the following weeks to approach adult levels (10 units) by seven weeks of age. Also, specific activity of DBH in heart increased rapidly during the first 2 1/2 weeks of life attaining adult levels by 18 days of age. In contrast, heart weight and total DBH activity in whole heart increased in a coordinate fashion at a relatively constant rate throughout the first seven weeks of life. Serum levels of non-copper sensitive endogenous inhibitor (s) of DBH increased throughout the first seven weeks of life while no change in copper sensitive inhibition was observed. Also, the rapid phase of decrease in serum DBH activity corresponded to the period of the most rapid increase in body weight.

Animals↗
PubMed1976

Reduction in brain tyrosine hydroxylase activity following acetylcholinesterase blockade in rats.

Activation of cholinergic neurons in the brain is produced by administration of the acetylcholinesterase inhibitors physostigmine and diisopropylfluorophosphate (DFP). This activation has a biphasic effect on tyrosine hydroxylase (EC 4.14.3-) activity. The acute effect of DFP, 1 mg/kg, intraperitoneally, or physostigmine, 0.2 mg/kg, intravenously, or 10 mug, intraventricularly, was a rapid reduction in tyrosine hydroxylase activity in the hypothalamus. The activities of DOPA decarboxylase (EC 4.1.1.28) and dopamine-beta-hydroxylase (EC 1.14.17.1) were not changed. In contrast to the acute effect, chronic administration of physostigmine, 0.2 mg/kg, intravenously, twice daily for 7 days produced an increase in tyrosine hydroxylase activity in the hypothalamus. The rapid acute effects may be due to an allosteric inactivation of tyrosine hydroxylase, while the chronic effects may reflect enzyme induction.

Animals↗