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Biomedical subjects

F Lazar

Publications and source records attributed to F Lazar.

10 recordsLinked to original sources
PubMed2005

[Chemodenervation with botulinumtoxin in masseteric hypertrophy].

BACKGROUND: Masseteric hypertrophy is a unilateral or bilateral enlargement of the masseteric muscle of various aetiologies. The therapeutic options range from solely conservative measures, especially in functionally induced abnormalities, up to surgical ablation of the muscle. The presented study evaluates the application of botulinum toxin serotype A for the treatment of masseteric hypertrophy. PATIENTS AND METHODS: Between June 2000 and August 2004 seven patients with a unilateral and one patient with a bilateral manifestation of the condition were treated by an injection of botulinum toxin. RESULTS: A significant improvement of facial asymmetry caused by chemodenervation and following reduction of the hypertrophic muscle mass could be achieved in all cases. Complications during the injection, side effects, signs of intoxication, and therapy failure were not observed. CONCLUSION: The results of this treatment series show in agreement with the reports in the literature that the application of botulinum toxin can be currently considered as the therapy of choice in masseteric hypertrophy.

Adolescent↗
PubMed2003

[Mucocele of the chin area. A rare complication after genioplasty with osteocartilagenous nasal bone transplant. Review of the literature and case report].

BACKGROUND: This paper describes an infrequent case of an intraosseous mucocele after chin augmentation using a nasal osseocartilaginous graft. Diagnostics, therapy, and clinical course of this rare complication are discussed based on our own experience and a review of the current scientific literature. CASE REPORT: Radiological examination of a 22-year-old patient revealed an oval lucent area approximately 3x1 cm in size with sclerotic rim. Cartilaginous material directly fused to the cyst wall was detected during surgery. The results of histological examination indicated parts of a cyst wall lined with respiratory epithelium located over normally maturing cartilaginous tissue. Postoperative long-term drainage with consecutive reduction of the cyst lumen was followed by cystectomy and concurrent osteoplasty and onlay graft. DISCUSSION: This case presented here is-as far as we know-one of three manifestations of a respiratory implantation cyst published. Its origin is most likely based on epithelium-like cells that have been incompletely removed from the resected nasal hump. Although severe complications of this technique have rarely been described, the surgeon must be aware of possible long-term side effects and should meticulously remove adherent nasal mucosa from the graft.

Adult↗
PubMed2001

Use of an image-guided navigation system in dental implant surgery in anatomically complex operation sites.

INTRODUCTION: Recent developments in computer assisted surgery have brought major improvements to maxillofacial surgery. Computer systems for intra-operative navigation have been introduced enabling the surgeon to locate the continually updated position of the instruments and the operation site on the patient's three-dimensional reconstructed image data set displayed on a monitor in the operating room. Complex surgical procedures can be performed according to the preoperative plan based on CT and/or MRI data minimizing surgical risks and optimizing clinical results. Nowadays computer-assisted-surgery has also proved effective in dental implantology. AIM: The objective of this study was to compare the accuracy of conventional and computer-assisted dental implantation planning and surgery. Analyzing our early experiences, we aimed to evaluate the benefit from utilising computer assisted surgery (CAS). PATIENTS: Five patients were treated with the aid of CAS, a total of 18 dental implants being placed. Only difficult operation sites, e.g. following bone augmentation or anatomically malformed jaws were included in this study. METHOD: An infra-red light based navigation system (Vector Vision 2, BrainLAB, Munich, Germany) including a three-dimensional planning approach for maxillofacial surgery was used. Placement of dental implants in the maxilla included direct visualization when drilling the implant socket according to the axis previously planned on radiographs and CT scans. RESULTS: In two cases the conventionally planned implant location had to be changed due to insufficient bone being available. With four implants, it proved possible to insert longer fixtures after the CAS system had evaluated all parameters of the surgical region. In one case a shorter implant was installed due to insufficient bone at the designated location. CONCLUSION: The use of an image-guided navigation system provides a valuable tool in implant dentistry and proved superior to conventional implant surgery especially in difficult anatomical regions.

Alveolar Ridge Augmentation↗
PubMed2000

[Micro- and macrodistraction of the jaw. A sure method of adding new bone].

Vertical distraction osteogenesis (VDO) has been developed by our study group to move dentulous and edentulous segments of the alveolar process vertically with a device in microplate-design. Besides these techniques of vertical distraction of the atrophic alveolar crest some further modifications as Micro- and Macro-distraction are available. Micro-distraction can be used in localised small defects of the alveolar crest with microplates and screws of 1.0 mm in diameter. In a pilot study we could treat 6 patients especially after traumatic bone loss of the alveolus. The lengths of the segments were 12.6 mm, the vertical distraction rate was 9.2 mm in average. Macro-distraction we call the distraction of the severely resorbed mandible in order to rebuild the vertical dimension of the weakened mandible. Vertical distraction osteogenesis of 13.6 mm was completed successfully in five patients with large segments of 119 mm lengths in average in a sandwich-technique. With a solid 2.3 basic plate a secure stability of the weakened mandible could be achieved. In contrast to bone transplantation an earlier mineralisation in the vertically distracted area could be seen by radiological examination and biopsy. We could insert dental implants in both pilot groups 3 months after distraction procedure. Main advantages of vertical distraction osteogenesis are: 1. No bone harvesting, 2. decreased resorption, 3. lower morbidity compared with conventional techniques, 4. lower infection rate and 5. feasibility to insert dental implants 3 months after distraction procedure, 6. gain of soft tissue.

Adolescent↗
PubMed1999

[Initial outcome of vertical distraction osteogenesis of the atrophic alveolar ridge].

Besides several conventional therapeutic regimens to treat severe forms of alveolar ridge atrophy the distraction osteogenesis is an alternative method. We introduced a new technique for the treatment of alveolar ridge atrophy encouraged by the advantages of distraction osteogenesis in the last decade. A new technique called "vertical distraction osteogenesis (VDO)" has been developed by our study group to move dentolous and edentolous segments of the alveolar process vertically with a device in microplate-design. Vertical distraction osteogenesis was completed successfully in nine patients with segments length ranging from 6.5 mm to 43 mm with an average of 23.7 mm. The vertical distraction rate was 9.9 mm on average in seven mandibular and two maxillar segments. In all cases we found good stability and the predicted movement of the segments. In contrast to bone transplantation an earlier mineralization in the vertically distracted area could be seen by radiological examination and biopsy. Five patients were treated with dental implants 12 weeks after distraction procedure. Main advantages of vertical distraction osteogenesis are: 1. No bone harvesting, 2. decreased resorption tendency, 3. lower morbidity compared with conventional techniques, 4. lower infection rate and 5. feasibility to insert dental implants 12 weeks after distraction procedure, 6. gain of soft tissue.

Adolescent↗
PubMed1991

[Rubeola in the population of Subotica 1978-1989].

The circulation of acute rubeola in the population of Subotica was analyzed from 1978 to 1989 regarding general and specific morbidity, the periodicity of occurrence and the cyclic increase in frequency. On the basis of a set clinical diagnosis 11246 cases of rubeola have been registered. Vaccination against rubeola is not conducted in Subotica, therefore this viral contagious disease has an endemoepidemic course. The highest epidemic waves have been registered in 1981 with 2117, and in 1984 with 2662 reported persons. The greatest agglomeration of those affected is in the age group of 5 to 9 years with 4475 (39.79%) of cases. The epidemic waves are divided by two calmer interepidemic periods in 1982 and 1983 as well as in 1986 and 1987. In the population of Subotica the occurrence of acute rubeola is increased at the end of winter with a predomination in the spring months.

Adolescent↗
PubMed1990

Prognostic factors for adenoid cystic carcinoma of the head and neck: a retrospective evaluation of 96 cases.

Cases of adenoid cystic carcinomas of the salivary (n = 90) and lacrimal glands (n = 6) from the years 1965-1980 were evaluated retrospectively with regard to clinical, epidemiologic and histomorphologic parameters, and in 52 cases, nuclear DNA content was assessed using a single cell scanning cytophotometry procedure in order to determine prognostic factors. Clinical courses were poor with a high incidence of recurrences, hematogenous metastases and deaths from tumor. Histology was related to prognosis, glandular tumors showing a better prognosis than solid ones. Tumor size greater than 4 cm was correlated with an unfavorable clinical course in all cases. Cytophotometry yielded various types of histograms (7 diploid, 10 proliferative, 14 triploid, 19 atypical, 2 tetraploid). Significant correlations were found as to the time of survival, tumors with diploid histograms showing the longest intervals and those with atypical ones the shortest. Although the prognosis of adenoid cystic carcinoma remains poor, cytophotometry can offer additional prognostic information in the individual case.

Adult↗
PubMed1979

Insulin and glucose responses in rats fed sucrose or starch.

Rats fed 54% sucrose for 11 to 13 weeks ad libitum or 5 weeks ad libitum followed by 6 to 8 weeks of meal feeding had significantly higher serum insulin, glucose, and triglyceride levels than rats fed comparable amounts of starch after 12 to 14 hr without food. The serum insulin response measured before, 1/2, and 4 hr after a meal showed insulin levels of sucrose-fed rats to be higher than comparable levels of rats fed starch at all three times. An intraperitoneal glucose tolerance test measuring serum glucose before, 1/2, 2, and 2 hr after a glucose injection revealed glucose levels of rats fed sucrose to be higher than levels of rats fed starch. When insulin was added to the injection medium, serum glucose of rats fed sucrose remained higher than comparable levels of rats fed starch indicating insulin insensitivity. Meal feeding generally resulted in higher insulin and triglyceride levels than in rats fed ad libitum but had little effect on glucose levels. These results are clear evidence that sucrose feeding has undesirable effects on glucose tolerance.

Adipose Tissue↗