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Biomedical subjects

F Le Bras

Publications and source records attributed to F Le Bras.

10 recordsLinked to original sources
PubMed1994

Randomised double blind trial of the safety and efficacy of two gadolinium complexes (Gd-DTPA and Gd-DOTA).

The main difference between macrocyclic Gd-DOTA and linear Gd-DTPA complexes is the greater stability of the former which theoretically might reduce biological interactions in man. To evaluate the clinical relevance of this property, 300 unselected neurological patients were included in a randomised double-blind comparison involving five European centres, focused mainly on the tolerance of these two contrast media. Clinical tolerance was assessed immediately after the procedure and 24 h later. Adverse events were found with a similar frequency in the two groups (17.3% for Gd-DOTA and 19.3% for Gd-DTPA). Minor neurological symptoms were the most frequent (48.6%) headache being the most common (29.2% of adverse events). No difference in efficacy was found.

Adult↗
PubMed1992

MRI anatomy of the acoustic-facial bundle in vivo.

In this study performed on 5 healthy volunteers the authors used oblique axial, coronal and sagittal MRI sections suitable to be anatomical configuration of the acoustic-facial bundle and were able to individualize the nerves forming this bundle throughout their course, with the sole exception of the intermediate nerve (VII2). They also analysed the relations of these nerves between themselves and with the other elements of the cerebellopontine angle. In addition, a proton-density sequence (SE, 6,000/30 ms) made it possible to differentiate in vivo between the grey matter and the white matter sufficiently to individualize the principal nuclei and tracts of the brain stem, and in particular the main vestibulo-cochlear central pathways.

Adult↗
PubMed1989

[The new imaging technics: theoretical principles, limitations and some ideas on costs].

The new imaging techniques modify the diagnostic, or even sometimes therapeutic, decision lines. Their efficiency is much greater than that of the old techniques, while pretium doloris and side-effects are considerably reduced. Such advances are not without a major disadvantage: the ever increasing cost of imaging explorations. Radiological guidance (with conventional radiology, ultrasounds and computerized tomography) facilitates percutaneous procedures for diagnostic (biopsy) or therapeutic purposes (emptying of abscesses, chemonucleolysis of herniated lumbar disc, etc.).

Angiography↗
PubMed1986

[Non-traumatic vertebro-epidural radiculo-spinal cord compressions: value of x-ray computed tomography coupled with myelography for lesion evaluation and therapeutic indications].

About 37 cases of non-traumatic spinal cord and cauda-equina compression, the authors emphasize the value of CT-scan study after intra-thecal injection of water-soluble contrast-medium. This exploration gives accurate informations about the involvement of both spinal and para-spinal spaces. These data are helpful diagnosis purpose and for the choice of therapeutic especially when surgical procedure is decided.

Adult↗