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Biomedical subjects

F Lecomte

Publications and source records attributed to F Lecomte.

45 records · Page 3Linked to original sources
PubMed1987

[Diffusion of 5-fluorocytosine in bronchial secretions in patients with respiratory insufficiency].

The 5-Fluorocytosine bronchial secretion levels of 14 patients with a chronic respiratory disease were determined using a microbiological method. The mean maximal concentrations (7.76 +/- 7 micrograms/ml) were obtained at the end of a single 25 mg/kg i v perfusion over 30 minutes. The level increased when five i v perfusions were performed every 6 hours and bronchial diffusion was higher and faster by concomitant administration of (bromhexin hydrochloride). Therefore, 5-Fluorocytosine was not found in bronchial secretions of four patients in spite of a normal serum levels (21.5 +/- 5 micrograms/ml).

Bronchi↗
PubMed1986

[Drugs used in a medical intensive care unit].

The treatments of 400 consecutive patients admitted in a 22-bed adult medical intensive care unit (ICU) were analysed prospectively. One hundred and thirty-one different drugs were prescribed with a mean of 5 +/- 4 drugs per patient (means +/- SD), during 8 +/- 11 days. The most commonly prescribed drugs were 1) preventive drugs, 2) antibiotics, 3) psychoactive drugs and analgesics. Two-thirds of the drugs were administered by a parenteral route. Mean daily cost was low: 57 FF per patient (6.3 US dollars, 1984), most of this being due to the prescription of antibiotics (59.8%). The wide range of drugs prescribed in different ICU precludes the compilation of a restricted list of drugs to be used in ICU. Nevertheless, prescription guidelines are suggested consisting of the discussion, for each patient, of the prescription of any of four types of drugs: those of the organ failure(s), of the underlying disease(s), preventive drugs, and finally comfort drugs.

Adolescent↗
PubMed1986

[Urinary tract infections in general medical practice. A study of clinical findings, of the distribution of causative microbial species and their sensitivity to 16 antibiotics].

From April to July 1984, all of the strains recovered by 10 private laboratories in Upper-Normandy region (France) from urine samples from outpatients seen in office practices (public and private hospitals excluded) were preserved. A total of 829 strains were collected, identified and tested against antibiotics using disk diffusion techniques. These investigations, together with a synthesis of clinical findings, were carried out by the Laboratory of Bacteriology of the Rouen University Hospital. 78.1% of patients were females; all age groups were represented with a greater prevalence of subjects aged 26 to 35 and above 66. E. coli was the most prevalent pathogen (74.5% of all strains), followed by Proteus and Providencia (10%). E. coli was recovered in 78% of first infections against 67.7% of recurrent infections and 50% of prostatitis. More than 25% of strains were resistant to ampicillin; norfloxacin showed the best activity, with 96.5% of susceptible strains.

Anti-Bacterial Agents↗
PubMed1983

[Sinus endoscopy in the diagnosis of rhinosinal pathology].

Findings in 86 endoscopic examinations of the nose and paranasal sinuses were compared with clinical and radiographic signs. Precise evaluations of endomaxillary lesions, including analysis of secretions, and histologic examinations were conducted. Clinical and endoscopic findings failed to concord in 28 p. cent of cases, and radiological and endoscopic images in 26 p. cent of cases, the majority of these errors arising because of homogeneous total filling of the sinuses. In spite of these divergences, endoscopy is relatively non-invasive and simple to perform, and occupies a place of choice in the diagnosis of disorders of the nose and sinuses. Sinus endoscopy can also be of therapeutic value, particularly for aeration of the sinuses and during minor surgical procedures.

Adolescent↗
PubMedDate not supplied

Efficacy of ciprofloxacin alone and in combination with azlocillin in experimental endocarditis due to Pseudomonas aeruginosa.

The efficacy of ciprofloxacin alone and in combination with azlocillin was compared with that of azlocillin plus tobramycin in a rat model of aortic valve endocarditis due to Pseudomonas aeruginosa. MICs against the infecting strain of ciprofloxacin, azlocillin and tobramycin were 0.125, 8, and 0.5 mg/l, respectively. Antimicrobials were administered 24 h after bacterial challenge and for six days. Mean peak/trough serum levels for ciprofloxacin (50 mg/kg i.v. q 12 h), azlocillin (500 mg/kg i.v. q 12 h) and tobramycin (6.5 mg/kg i.v. q 12 h) were: 10.5/0.2, 386/less than 16, and 6.2/less than 0.6 mg/l, respectively. Ciprofloxacin alone was more effective than the combination azlocillin-tobramycin in increasing survival (p less than 0.05), sterilizing blood (p less than 0.05) and valves (p less than 0.001), and in reducing bacterial titers in vegetations (p less than 0.001). Ciprofloxacin-azlocillin combination was not more effective than ciprofloxacin alone. Drug resistance was not encountered in post-treatment isolates with any therapy regimen.

Animals↗
PubMedDate not supplied

An uncommon association: celiac disease and dermatomyositis in adults.

We describe the case of a patient with a two-year history of adult dermatomyositis (DM) who developed malabsorption revealing celiac disease. Our observation raises the question of an association between DM and celiac disease as part of a continuum, suggesting that celiac disease may be included within the spectrum of the gastrointestinal manifestations of DM and polymyositis (PM). From a practical point of view, our data indicate that the diagnosis of celiac disease should be suspected in PM/DM patients exhibiting malabsorption syndrome. Based on our findings, we further emphasize that an evaluation for celiac disease, including anti-gliadin antibodies, anti-endomysium antibody and tissue trans-glutaminase antibodies should be considered in PM/DM patients presenting with unusual and unexplained gastrointestinal features. This could lead to the early management of such patients, resulting in decreased morbidity (i.e., malnutrition and malignancy) related to misdiagnosed celiac disease.

Celiac Disease↗