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Biomedical subjects

F Legault

Publications and source records attributed to F Legault.

7 recordsLinked to original sources
PubMed2004

Diverse effects of Ace inhibitors and angiotensin II receptor antagonists on prevention of cardiac hypertrophy and collagen distribution in spontaneously hypertensive rats.

This study has compared the effects of two structurally different angiotensin converting enzyme inhibitors (ACEis) such as zofenopril (Zof, with sulfhydrylic group) and lisinopril (Lis, with carboxylic group) and an angiotensin II AT(1) receptor antagonist (losartan, Los) on the prevention of cardiac hypertrophy and collagen distribution in spontaneously hypertensive rats (SHRs). The SHRs were untreated or received: Zof (10 mg/kg/day), Lis (10 mg/kg/day) or Los (20 mg/kg/day) in drinking water starting at 4 weeks of age. At 8, 16 and 24 weeks of age, 8 rats/group were sacrificed for determination of blood pressure, cardiac hypertrophy and collagen distribution. All treatments significantly decreased blood pressure and cardiac indices, expressed as the ventricles to body weight ratio, both variables being significantly correlated. Total ventricular collagen content was similarly decreased in all treated groups. Zof significantly increased the expression of collagen type III and normalized the collagen type I/III ratio. These results suggest that the effects of these drugs on different types of collagen are independent from angiotensin II formation. Similar findings obtained with captopril seem to indicate that the antioxidant sulfhydrylic group of these ACEis can play a role in the distribution of collagen during cardiac hypertrophy.

Angiotensin II Type 1 Receptor Blockers↗
PubMed1998

Frontal dysfunction in neurologically normal chronic alcoholic subjects: metabolic and neuropsychological findings.

BACKGROUND: Neuropsychological and imaging studies suggest that frontal dysfunction may occur in apparently normal chronic alcoholic subjects. METHODS: To investigate this issue further, we performed neuropsychological and fluorodeoxy-glucose-PET studies in 17 chronic alcoholics without patent neurological and psychiatric complications. RESULTS: Metabolic abnormalities were found in the mediofrontal and in the left dorsolateral prefrontal cortex, but not in the orbitofrontal cortex. Neuropsychological testing revealed significantly reduced verbal fluency and impaired performance on the Stroop test. The mediofrontal hypometabolism correlated with the reduction in verbal fluency and the time necessary to perform the interference condition of the Stroop test. The left dorsolateral prefrontal hypometabolism correlated with the number of errors on the Stroop test. CONCLUSION: These data indicate that circumscribed frontal dysfunctions may occur in chronic alcoholic subjects before clinically obvious neurological complications, and may account for some of the alcohol-related neuropsychological and behavioural impairments.

Adult↗
PubMed1990

Functional and morphological characteristics of compensated and decompensated cardiac hypertrophy in dogs with chronic infrarenal aorto-caval fistulas.

The relation between cardiac hypertrophy, shunt size, myocardial contractility, capillary density, adrenergic responsiveness, and neurohumoral stimulation was evaluated in dogs with compensated and decompensated cardiac hypertrophy caused by an infrarenal aorto-caval shunt. Shunt size varied from 5 to 35 mm2 due to an inability to create a uniform size. Dogs that developed heart failure within 4 months had 25 +/- 2 mm2 shunts, whereas those that developed it after 4 months had 19 +/- 3 mm2 shunts; those that did not develop heart failure had 10 +/- 1 mm2 shunts. Hypertrophy developed at the same rate in all the dogs that developed heart failure, which occurred at a critical heart weight (hypertrophy) for a given load (shunt size). In the dogs with heart failure there was a decrease in myocardial contractility (tension = 5.7 +/- 0.6 vs. 7.3 +/- 0.3 g/mm2, p less than 0.05), a decrease in adrenergic responsiveness (maximal heart rate with isoproterenol = 203 +/- 7 vs. 249 +/- 5 beats/min, p less than 0.01), an increase in circulating neurohormones, and a decrease in urinary sodium excretion (0.4 +/- 0.1 vs. 5.0 +/- 1.3 meq/3 hr, p less than 0.01). None of these abnormalities occurred in dogs with compensated hypertrophy. There were no differences in cardiac capillary density between the control dogs and the dogs with compensated cardiac hypertrophy or heart failure. Thus, it would appear that if heart failure is to develop after an initial toleration of a sudden volume overload, it will develop at a given combination of cardiac hypertrophy and volume overload, with cardiac hypertrophy developing at the same rate in all cases. In this model, once heart failure develops, myocardial contractility and cardiac adrenergic responsiveness are decreased and there is pronounced neurohumoral activation. All these changes are absent in hearts with compensated hypertrophy.

Adaptation, Physiological↗
PubMed1988

Slowing of cognitive processing in progressive supranuclear palsy. A comparison with Parkinson's disease.

To investigate central processing time in patients with progressive supranuclear palsy and Parkinson's disease, reaction times were measured using tasks with different levels of cognitive complexity but with the same motor response. In patients with Parkinson's disease, the additional central processing time required for more complex situations was no different from that in control subjects, suggesting that cognitive aspects of the reaction time procedures tested were possibly too simple to reveal a slowing of thought processes in these patients. Conversely, the central processing time was increased in patients with progressive supranuclear palsy compared with both Parkinson's disease and control subjects. The increase was associated with impairment in frontal lobe test performance. These results confirm that a slowing of central processing is a prominent feature of the cognitive disturbances of progressive supranuclear palsy and, furthermore, suggest that this slowing may be related to striatofrontal dysfunction.

Aged↗
PubMed1987

Metaiodobenzylguanidine [131I] scintigraphy detects impaired myocardial sympathetic neuronal transport function of canine mechanical-overload heart failure.

In heart failure secondary to chronic mechanical overload, cardiac sympathetic neurons demonstrate depressed catecholamine synthetic and transport function. To assess the potential of sympathetic neuronal imaging for detection of depressed transport function, serial scintigrams were acquired after the intravenous administration of metaiodobenzylguanidine [131I] to 13 normal dogs, 3 autotransplanted (denervated) dogs, 5 dogs with left ventricular failure, and 5 dogs with compensated left ventricular hypertrophy due to a surgical arteriovenous shunt. Nine dogs were killed at 14 hours postinjection for determination of metaiodobenzylguanidine [131I] and endogenous norepinephrine content in left atrium, left ventricle, liver, and spleen. By 4 hours postinjection, autotransplanted dogs had a 39% reduction in mean left ventricular tracer accumulation, reflecting an absent intraneuronal tracer pool. Failure dogs demonstrated an accelerated early mean left ventricular tracer efflux rate (26.0%/hour versus 13.7%/hour in normals), reflecting a disproportionately increased extraneuronal tracer pool. They also showed reduced late left ventricular and left atrial concentrations of tracer, consistent with a reduced intraneuronal tracer pool. By contrast, compensated hypertrophy dogs demonstrated a normal early mean left ventricular tracer efflux rate (16.4%/hour) and essentially normal late left ventricular and left atrial concentrations of tracer. Metaiodobenzylguanidine [131I] scintigraphic findings reflect the integrity of the cardiac sympathetic neuronal transport system in canine mechanical-overload heart failure. Metaiodobenzylguanidine [123I] scintigraphy should be explored as a means of early detection of mechanical-overload heart failure in patients.

3-Iodobenzylguanidine↗
PubMedDate not supplied

Advancing nursing practice: an evaluation study of Parse's theory of human becoming.

The purpose of this study was to evaluate the changes in nursing practice and the patient/family perspectives of nursing care when Parse's theory of human becoming was used as a guide for nursing practice in an acute care surgical setting. The patterns of transition in nursing practice were: understanding the unique contribution of nursing from a theoretical perspective; living value priorities to enhance quality of care for patients and families; shifting the focus of care from problems to the nurse-person relationship; finding meaning in nursing through reflection on self and others; supporting colleagues to move towards patient centred care; persisting with new ways while facing resistance to change; and enhancing personal and professional growth. It is evident from the positive patterns of change in nursing practice and patient and family experiences of nursing care that Parse's theory of human becoming is congruent with and supports patient centred nursing practice.

Aged↗