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Biomedical subjects

F Lemoigne

Publications and source records attributed to F Lemoigne.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Diagnostic and therapeutic approach in thromboembolism disease. Reflexions apropos of 105 cases].

105 patients suffering from thrombo-embolic disease (MTE) were explored by venography of the lower limbs, ilio-vena cavography and pulmonary angiography at the time of the initial diagnostic work up. These examinations served as a control for the different therapies, anticoagulants, thrombolytics, curative and preventive surgery, separately (77 controls) or in association (92 controls). From the base-line vascular investigations it appears that the gravity of the pulmonary emboli was not correlated with either a proximal or distal site of venous thrombosis. From the results of controlled therapy there were significant differences between the efficacy of medical treatment at the level of the pulmonary artery and at venous level where the progression of phlebo-thrombosis was often seen. Recurrence of emboli and overall prognosis of the disease usually depended on the persistence of thrombi at venous level. Such a phlebo-thrombosis is rarely aggravated by techniques of partial interruption of the inferior vena cava (IPVCI) which ensure effective protection of the pulmonary circulation. The IPVCI often appears to be the only effective method of preventing recurrent pulmonary emboli, which has led us to reconsider its indications.

Angiography↗
PubMed1983

[Prevention of pulmonary embolism by the Kimray-Greenfield filter. 22 cases].

At present, the Kimray-Greenfield filter appears to be the best intraluminal method for preventing thromboembolism, as it is simple, effective and innocuous. The authors report their experience in the first 22 cases. They were surprised by the frequent problems encountered in installing the filter, especially by the femoral route. Two accidents occurred during the procedure: a filter introduced through the jugular vein migrated as soon as it was released, and a patient developed sudden and irreversible coma during passage of the guiding instrument behind the clavicle. Cavographies performed in 10 patients after one month or more disclosed two thromboses of the inferior vena cava and a tipped-over filter. Eight filters remained permeable. No recurrence of pulmonary embolism was observed.

Aged↗
PubMed1983

[Value of the test of unilateral pulmonary artery blocking in the preoperative evaluation of bronchial cancer].

Results of the test of unilateral blockage of a pulmonary artery (UBPAT) were compared with those of respiratory function tests in the pre-operative investigation of 31 patients with bronchial cancer. Results were also compared with functional tolerance of patients treated by pneumonectomy. Follow-up hemodynamic explorations were performed postoperatively in eight of these patients. Values for pulmonary artery pressure obtained during the UBPAT appear to be much more discriminatory than the ventilatory parameters studied for predicting functional tolerance following pneumonectomy. Apart from some complexity in its performance this test appears to be a valid one, when associated with pulmonary angiography, for pre-operative investigation of bronchial cancer patients at high functional risk.

Aged↗
PubMed1982

[The theophylline test. Indications for the effective daily dosage (author's transl)].

The great variability in the metabolism and degradation of theophylline in different people demands an individual dosage to be effective; this is to maintain the theophylline levels between the threshold of therapeutic activity (10 mg/L) to the upper limit of tolerance (15 to 20 mg/L according to different studies). The effective individual doses may be determined before commencing treatment by a Theophylline Test. This allows the dose over 24 hours to be specified as well as the number of tablets necessary to maintain the theophylline levels in the chosen range. The principle of the Theophylline Test is to administer intravenously a test dose of theophylline, then with 5 successive samples for blood theophylline to assess the individual elimination of the drug. For each subject two pharmacokinetic parameters are determined: clearance and plasma half life. The plasma clearance allows the total dose over 24 hours to be calculated, the half life the number of doses and the type of preparation used: microkrystalline theophylline (Techniphylline), slow release theophylline (Theophylline Bruneau) and prolonged action theophylline (Armophylline).

Adolescent↗
PubMed1979

[Diurnal variations evidence of glomerular filtration in the rat (author's transl)].

Parallel variations in plasma and urine variations of endogenous urea and creatinine level in the rat during 4 consecutive 6-h-long periods permit to evidence urea and creatinine clearance diurnal variations with very significant increase in the 2 nightly periods. The signification of this very large nightly glomerular filtration increase is discussed.

Animals↗
PubMed1979

[Effect of the time of theophylline administration on the intensity of diuresis and natriuresis in the rat].

The present study originates in two experimental data: circadian variations evidence of water, electrolytes and solutes urinary excretion and theophylline diuretic and salidiuretic effects knowledge; we purpose to evidence theophylline-induced water and sodium renal excretion in rats as modified by the time of drug administration. Theophylline single dose is injected in 100 animals (20 lots of 5 rats) at 8 h, 14 h, 20 h or 2 h and urines are collected during a consecutive to injection hours long period: 8 h-14 h (I), 14 h-20 h (II), 20 h-2 h (III) or 2 h-8 h (IV). Diuresis increases in + 40,4 p. cent (I), in + 123,7 p. cent (II), in + 123,3 p. cent (III) in + 65,4 p. cent (IV). So, natriuresis increases in 39,6 p. cent (I), in 223,2 p. cent (II), in 114,3 p cent (III) and in 109,6 p. cent (IV). These results evidence that theophylline diuretic and natriuretic effects change strongly with injection time, being largest if it is injected at 14 h and slightest if injected at 8 h. Such observations prompt to study if the other pharmacological properties of theophylline, especially at pulmonary level, response also with a time-dependant intensity.

Animals↗
PubMed1978

[Nycthemeral variations of blood and urine urea, creatinine and total proteins in rats].

The present study evidences blood and urine urea, creatinine and total proteins circadian variations in 50 male rats. Venous blood is sampled at behind socket sinus once a week at different hours (8, 11, 14, 17, 20, 23, 2 and 5) and urines are collected during 4 consecutive six hours periods in animals living in metabolism cages (8-14, 14-20, 20-2, 2-8). Blood three nitrogen substances circadian variations bring out the decrease at 17 h and increase at 23 or 2 h. Urinary excretion variations curves shows, in all cases, an increase more than 40% during the nightly periods. The influence of feeding rhythms on the blood and urine three derivates circadian rhythms is discussed. Moreover, night diuresis increase and urea and creatinine urinary remarkable constancy suggest water, solutes and macrosolutes transglomerular pathway nightly increase existence. Urea (+ 40%) and creatinine (+ 30%) clearance nightly significative increase confirms glomerular filtration circadian variations and its nightly increase.

Animals↗
PubMedDate not supplied

[Comparative clinical evaluation of two mucolytic agents: S-carboxy-methyl-cysteine and letosteine (author's transl)].

A controlled double-blind clinical trial comparing a noval medicament, letosteine, to a known bronchial fluidifier, S-carboxy-methyl-cysteine, was conducted on a total of 47 hospitalized patients suffering from various types of chronic obstructive lung disease. Daily observations were made on the patients themselves and on sputum samples obtained from them before, during and after the course of mucolytic therapy. When the code was broken at the end of the trial, there appeared no significant difference between the patient groups treated with the two drugs regarding either changes in respiratory symptoms or changes in sputum characteristics. Thus, in this study, letosteine (50 mg t.i.d.) appeared equivalent to S-carboxy-methyl-cysteine (750 mg t.i.d.) in the treatment of chronic obstructive lung disease in adults.

Aged↗
PubMedDate not supplied

[Comparative in vitro and in vivo study of several long-acting theophyllines].

This study describes the comparative in vitro and in vivo release of six slow-release formulations. In vitro, with half-change method, differences appear in the profiles, some formulations showing a linear release (Dilatrane, Euphylline LA, Théostat), the others an irregular release with 'plateau' related to the pH gradient (Armophylline, Cétraphylline, Théolair). In vivo, at steady state, the fluctuations are less important and the comparative kinetic study in ten normal healthy volunteers after chronic oral dosing of six different formulations show a slight variability in the theophylline release during 12 h. Great interindividual variations appear with all formulations. In fact, none of the formulations present an ideal release over a 12 h period.

Adult↗