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F Leperchey

Publications and source records attributed to F Leperchey.

At least 19 recordsLinked to original sources
PubMed1992

[Aspects of facial morphogenesis in the rat].

The facial morphogenesis of the rat has been observed by scanning microscopy on embryos taken every day from the 10th post-coitum day to term. Three points should be noted. Firstly the muzzle has at the beginning of the development an individuality which tends to diminish later. Secondly the vibrissae, whose primary elements are grouped in plates, are of great importance in the development of the muzzle. Finally, the opening between the internal parts of the nasal ridges is elevated with at the top a sharp angle, contrary to that of man which is little elevated and is arched. This could express the difference relating in each of the two cases the mesenchymatous naso-dorsal center, to which divergence between the two types of face, one with muzzle and the other without, would be linked. The primates presenting these two types, the tendency at the moment is to classify them using this discrimination. The study of the two corresponding aspects would supply a precious addition to these observations.

Animals↗
PubMed1987

[Role and significance of the branchial system in cervico-facial morphogenesis].

The so-called "branchial" embryonic organization is in fact that of the part of the embryo subjacent to the anterior, encephalic portion of neural tube. It presents, in addition to its typical aspects, historically of importance, other more pertinent aspects related to its segmental character, its mode of development and its morphologic limits. Synthesis of all data is now possible due to recent precision of the origin of branchial muscles and the participation of ectomesochyme in its development. Findings indicate the predominant place and deep significant of this organization in overall embryonic development, for which it represents a determinant phase in itself, independent of evolutionary potential that can be possibly attributed to its vascular components.

Biological Evolution↗
PubMed1987

[Demonstration of a correlation between the degree of pigmentation and the power of inactivation of isoniazid in man].

In a group of 153 white subjects treated for tubercle, individual determinations were made of: a) The power of inactivation of isoniazid. b) The degree of pigmentation (iris, skin, hair) assessed by a weighted pigmented index of the iris. A statistical study of the results shows the clear existence of a narrow positive correlation between these two characters, such that the more pigmented a subject is, the greater is the chance of rapid inactivation of isoniazid. An attempt at a biochemical explanation is proposed. The results in the world literature (Japanese, Swedish, American) are in keeping with these observations. Thus, weakly pigmented tuberculous patients are potentially a new group at risk from anti-TB drugs.

Eye Color↗
PubMed1985

Power of isoniazid acetylation and pigmentation; first experimental tests in the rabbit: comparison with clinical data.

A positive correlation has been observed clinically at the Centre Edouard Rist, Paris, between the degree of pigmentation and the power of isoniazid acetylation in so-called "caucasians". The investigation was based on a relatively small sample of 153 observations, but sufficient to allow a significant statistical analysis. Comparing the results with data published in the literature, it may be assumed that this relationship between the power of acetylation and pigmentation would be applicable to all human beings. The rabbit, having as in man a bi-modal distribution of the power of acetylation, was used for further research of this correlation in that animal. The results of this research in rabbits may be compared with those in man, but further studies are required in view of the interest of this comparison and of the possible consequences of the relationship of pigmentation and the degree of acetylation of isoniazid in human therapeutics.

Acetylation↗
PubMed1983

[2 modalities in the embryogenic process of frontonasal cysts and fistulae].

The two principal embryogenic theories, persistence of residual structures remaining after closure of the anterior neuropore and inclusion of epiblastic derivatives in the prenasal space, may be combined, with resulting two embryonic varieties of these malformations. Glabellar cysts, with or without fistulae extending them downwards, and which remaining at superficial level may perforate the true nasal bones. Other fistulae can develop which extend deeply and present variable dilatations with a more or less oblique path upwards depending on the level of their opening into the nose.

Cysts↗
PubMed1983

[Proboscis lateralis, a rare facial malformation. Therapeutic difficulties (apropos of a case)].

A case of proboscis lateralis with total absence of the corresponding half of the nose is reported. The length of the mucocutaneous cylinder enabled initial insertion of its free extremity around its bony orifice in communication with the single nasal fossa, and the creation of a functional, well situated naris. Second-stage operation several months later involved spreading of the upper part, closure of the coloboma, and treatment of the lacrimal pathways. Total liberation of the superior pedicle and final modelling is to be envisaged at a later date as a function of growth.

Child, Preschool↗
PubMed1983

[Embryologic problems raised by proboscis lateralis].

Organization is conserved in proboscis lateralis and in this respect it represents a half-nose and not a nasolacrymal canal. It is characterized by mainly skeletal deficiency and a paramedian lateral localization. Associated alterations involved olfactory and ocular structures, often with a disorder of closure of the colobomic slit, but overall neuroblast development is not disturbed. Effects on the subjacent facial regions are variable and remain lateral, the overall situation in relation to Tessier's fissure tending to clarify their significance. Comparison of the malformation with the different degrees of cyclopia and with the bifid nose confirms its origin from a particular form of embryogenic process. Significance of participation of the olfactory placodes and the neighboring ectomesenchyme is discussed, together with the modalities of this participation. The latent bilateral nature of the malformation must be recognized together with its embryogenic consequences.

Face↗
PubMed1979

[Embryogeny of facial, mastication, tongue, palate and neck muscles (author's transl)].

The mesenchymal origin muscular tissues entailing some difficulties in the knowledge of certain muscles embryogeny, two methods are therefore applied: the comparison of the ontogenesis data with those of comparative anatomy and the use as a guide of the functional motor unit with which the muscle combines. In resorting to these methods necessary precautions are precisely defined. The origins of the concerned muscles are, at first, situated among those of the whole musculature subjected to will, which are of two types "somitic" and "branchial". The realities lying under these two misleading terms are analysed. Then the usual data on each of the muscular groups embryogeny reviewed and compared, if necessary, with recent works. For the facial muscles a confusion results from the use of the term platysma both in comparative anatomy and in embryology, in pursuance of transposition, exact on that particular point, of the philogenic development of these muscles in ontogenesis. The development of these muscles comes in the scope of the extensive general character of the superficial hyoïd arch derivatives, and their topographic and functional particularities should be brought together with the disposition of the facial nerve nucleus and its arising fibres. Among the muscles in action in the mastication, a link appears between their precise role in this function and their embryogeny. For the neck muscles, the spinal nerve systematisation and the variations of the sterno-mastoïd muscle in mammals agree in assigning to this muscle an entire somitic origin lying exactly at the junction with the so-called branchial muscles. The somitic origin of the tongue muscles and the sharing between the somitic and branchial origins of those of the soft palate bring to light the place in the organism of these two anatomic structures. Then, the conjunction of muscles proceeding thus from two origins in these anatomic structures carries a particular signification in man by reason of the language.

Anatomy, Comparative↗
PubMed1977

[The embryology of cysts and fistulae of the neck (author's transl)].

The term "branchial" should not lead to errors of interpretation and of classification. The essential points of normal embryology and comparative anatomy are reviewed: the special nature of the first entobranchial or spiracular pouch, the important role played in correlation by the second pouch, the general course of the two parts, external and internal, of the branchial apparatus and, finally, with regard to the latter, the problems posed by the development of lymphoid tissue in this region. The thyroglossal duct, although distinct from the branchial apparatus, remains in close relationship with it, in particular in the region of the hyoid where median cysts do not have an exclusively, thyroid origin. Amongst the lateral fistulae and cysts, the different types of which are described in relation to the tissue of their origin, the distinction must be drawn between two main types: those derived from the second pair of branchial pouches and those derived from the third entobranchial pouch only. It should be possible to recognise them on the basis of the characteristics described before operation, the latter being different in the two cases.

Branchioma↗