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F Lhermitte

Publications and source records attributed to F Lhermitte.

At least 37 records · Page 2Linked to original sources
PubMed1978

[Epidemiology of Creutzfeldt-Jakob disease in the Paris area].

The area studied includes the city of Paris and the neighboring departments of Val-d'Oise, Seine-Saint-Denis, Hauts-de-Seine, Yvelines, Essonne, Val-de-Marne, and Seine-et-Marne. Case finding methods and diagnostic criteria are defined. The temporal and spatial distribution of cases is described, and the absence of case clustering is noted. Incidence per million people (per year) was found to be 1,09 in the city, 0,55 in the adjacent departments, and 0,25 in the peripheral departments. These results are discussed.

Age Factors↗
PubMed1978

[Quasi-aphasia associated with thalamic lesions: relation between the language disorder and elective activation of the left hemisphere in 4 cases of left and right thalamic lesions].

The authors report on four patients with vascular lesions of the thalamus, three on the left side and one on the right, two of which were due to haemorrhage and two to infarcts. Language difficulties were observed in those cases with left thalamic lesions only. Speech was either slower or faster than normal, and there were verbal perseveration, semantic paraphasia, and more especially, reduction in verbal fluency with loss of control of logic, causing a true jargon in some tests in certain cases. Articulation, and phonemic programming were unaffected, as were comprehension, reading and writing. A comparison is made between these findings and those reported in the literature. Among the hypo-theses suggested, the authors subscribe to that which accepts the predominant role played by the interruption of the activating system of the left hemisphere by the thalamic lesion. The relative inactivation resulting from this could produce modifications in language dynamics and disturbances in attention in relation to language. The semantic paraphasia could be related to the intrusion of the right hemisphere apparatus into language, because of the lack of balance between the activation of each of the two hemispheres. The fact that thalamic lesions are characterized by language disorders would tend to show that sub-cortical dynamic factors constantly regulate the activation of the hemispheres.

Adult↗
PubMed1977

[Chloroquine neuromyopathy. One case in prophylactic maleriatherapy (author's transl)].

A case of neuromyopathy due to chronic chloroquine intoxication is reported. The neuromyopathy developped 9 months after malaria suppression therapy with chloroquine was started. The clinical picture was that of a peripherical neuropathy in the lower limbs and of a generalized myasthenic syndrome. Muscular biopsy showed typical pictures of "vacuolar myopathy". The metabolism of the drug was normal. The patient improved soon after chloroquine was discontinued.

Adult↗
PubMed1977

Signs of interhemispheric disconnection in marchiafava-bignami disease.

We report three cases of Marchiafava-Bignami disease. The diagnosis was made on clinical grounds. Evidence of interhemispheric disconnection was found in all three cases. This included left hand anomia, left-sided apraxia, left-hand agraphia, and left-sided pseudoextinction to both visual and tactile stimuli. In two cases, there was a left-ear extinction on a dichotic listening test.

Alcoholism↗
PubMed1977

[Abnormal movements of patients with Parkinsonism treated with L-dopa and anomalies of dopamine metabolism].

The authors describe the results of biochemical analysis carried out on 28 patients with Parkinson's disease who had been treated by L-dopa. Twenty of them showed either no abnormal movements at all or very few, eight others had considerable dyskinesia. Biochemical analysis of the urinary degradation products of L-Dopa revealed the existence of a swing in the degradation of dopamine towards 4-O-methylate derivatives in dyskinetic patients (significant difference at .01). The results confirm those obtained in their initial analysis carried out in 1973. The authors express the view that abnormal movements while under L-Dopa treatment are dependent on two factors: one, the hypersensitivity of dopaminergic reception, the other, the greater or lesser preponderance of the COMT isozyme giving rise to 4-O-methylates;

Dopamine↗
PubMed1977

[Recording of visual evoked potentials in the diagnosis of multiple sclerosis].

The authors report the results of recording EVP obtained by pattern reversal in 20 controls and 43 patients with "established", "probable" or "possible" MS on the basis of MacAlpine's criteria. Whilst the latency of the wave 1 of the EVP appeared stable in the controls (107.5 msec +/- 7.46), lengthening of the latency of the EVP was seen in 77p. 100 of cases, confirming involvement of the visual pathways, though bulbar neuritis had been known clinically in only 28 p. 100 of patients. The value of this method of recording EVP in contributing to the diagnosis of DS is discussed.

Adolescent↗
PubMed1977

["Beginning and end of dose" dyskinesias caused by L-DOPA].

The four cases of dyskinesia at the "beginning and end of dose" caused by L-Dopa presented in this series were characterized by four essential features: 1) their onset at the beginning and end of the period of effectiveness of a dose of L-Dopa + IDC (benserazide); 2) their ballic and dystonic appearance associated with a reinforcement of Parkinsonian signs; 3) the possibility of their reduction by an increase and fractionning of the daily dose of L-Dopa; 4) the particular nature of the underlying Parkinsonian problem in which they were seen, i.e. the young age at onset of the disease, the severity of akinesia, and the quality of the clinical response to L-Dopa. Thus on the basis of the circumstances of their development, their appearance, and their treatment, such forms of dyskinesia at the "beginning and end of dose" appear to be different from classical "mid-dose" dyskinesia. In addition, they pose a new physiolopathological problem.

Benserazide↗
PubMed1976

A study of visual processes in a case of interhemispheric disconnexion.

A 75-year-old right-handed woman, after a probable cerebral infarct, developed an irregular constriction of the visual fields, a left-sided agraphia, and an anomia for objects in the left hand. Subsequent testing demonstrated an inability to name, though ability to recognize, letters and objects flashed in the homonymous left visual field. An inter-hemispheric disconnexion syndrome was inferred from these findings. The present publication concerns mainly the visual aspects of this disconnexion syndrome. Tasks were devised to test the abilities of the major and minor hemisphere: (a) the left hemisphere demonstrated a complete dominance for language expression and an incomplete dominance for written language comprehension; (b) the right hemisphere appeared to be dominant for some visuo-spatial tasks including number comprehension; (c) when the hemispheres were given contradictory visual informations on a non-verbal task (chimeric stimuli) there was a predominance of the right hemisphere. The right hemisphere appeared able to process complex information. Specialization of functional activities in each hemisphere is briefly discussed.

Aged↗
PubMed1976

[Amnesiac aphasia. Study of 25 cases].

Twenty-five patients with "amnesic aphasia" were studied. The language difficulty is not related either to intellectual deficit, generalised memory disturbance or visual impairment but is a specific verbal memory defect. Amnesic aphasia also involves lack of perception of linguistic units which is caused by impairment of comprehension and erasure of the acoustico-mnesic traces of words. The responsible lesions are in the left temporal region. The authors maintain that, from the physio-pathological point of view, these lesions do not destroy the cortex and sub-cortex, as in focal necrosis, but cause cortical dysfunction selectively affecting the mnesic traces of words.

Adolescent↗
PubMed1975

Plasma galactocerebrosides in multiple sclerosis.

Plasma cerebrosides were examined in 12 cases of multiple sclerosis which were compared to normal controls and patients with cerebrovascular accidents. A screening was performed so as to select patients with levels above to normal by means of thin-layer chromatography of the lipid extract. Glucose seems to be the only hexose to be found normally in plasma cerebrosides. The presence of galactocerebrosides may be a biological test for demyelination, as their presence seems to be related to the evolutionary state of multiple sclerosis. In a severe cerebrovascular accident, galactocerebrosides were also found.

Adult↗