PubMed Health⌕ Search

Biomedical subjects

F Lindgren

Publications and source records attributed to F Lindgren.

At least 37 records · Page 2Linked to original sources
PubMed1987

Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes.

Antibodies in sera from newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients are directed to a human islet cell protein of relative molecular mass (Mr) 64,000. Since IDDM seems to develop after a prodromal period of beta-cell autoimmunity, this study has examined whether 64,000 Mr antibodies could be detected in 14 individuals who subsequently developed IDDM and five first degree relatives who have indications of altered beta-cell function. Sera were screened by immunoprecipitation on total detergent lysates of human islets and positive sera retested on membrane protein preparations. Antibodies to the 64,000 Mr membrane protein were consistently detected in 11/14 IDDM patients, and in all 5 first degree relatives. 10 IDDM patients were already positive in the first samples, obtained 4-91 mo before the clinical onset of IDDM, whereas 1 patient progressed to a high 64,000 Mr immunoreactivity, at a time where a commencement of a decline in beta-cell function was detected. 64,000 Mr antibodies were detected before islet cell cytoplasmic antibodies (ICCA) in two patients. In the control groups of 21 healthy individuals, 36 patients with diseases of the thyroid and 5 SLE patients, the 64,000 Mr antibodies were detected in only one individual, who was a healthy sibling to an IDDM patient. These results suggest that antibodies against the Mr 64,000 human islet protein are an early marker of beta-cell autoimmunity and may be useful to predict a later development of IDDM.

Adolescent↗
PubMed1987

The effects of smoking and physical exercise on temporary threshold shifts.

The Temporary Threshold Shifts (TTS) of 9 habitual smokers and 9 non-smokers were determined twice (via Békésy sweep procedures) after each of three conditions: 10 min of physical exercise, 10 min of 105 dB SPL exposure to a third octave band noise centered around 2 kHz, and 10 min of both exercise and noise. Smokers evidenced less TTS than did non-smokers, particularly when exposed to both noise and exercise and especially in the range of 2.5 to 5 kHz. Heart rate and systolic blood pressure increased more for smokers than for non-smokers, particularly when they were required to exercise. Oral temperature was positively correlated with the magnitude of TTS.

Adolescent↗
PubMed1986

Temporary threshold shift induced by noise exposure and moderate salicylate intake.

Temporary threshold shift was examined in 10 voluntary subjects who were exposed on 5 occasions to noise only and on 5 additional occasions to noise after intake of 1 g acetylsalicylic acid (ASA). The results showed no evidence that moderate doses of ASA potentiate temporary threshold shift. Subjects tested before and 1 hour after intake of ASA showed hearing improvement after intake of ASA. This threshold shift was confirmed, by a control trial, to depend on a practice effect rather than on the ASA.

Adolescent↗
PubMed1986

The effect of buflomedilhydrochloride (Loftyl) on temporary hearing threshold shift.

Buflomedilhydrochloride (Loftyl, Abbott) is a vasodilating agent which has proved not only to influence peripheral blood vessels but also cerebral vascular disease. We tested the ability of Buflomedil to prevent noise-induced temporary threshold shift (TTS). Ten individuals tested the active substance and placebo 5 times each at random. In the individual analysis comparing Buflomedil and placebo sessions, there was a statistically significant decreased TTS after Buflomedil.

Adult↗
PubMed1984

Self-monitoring of blood glucose by diabetic women during the third trimester of pregnancy.

The clinical value of self-monitoring blood glucose in diabetic pregnancy at home was compared with hospital care in the thirty-second to thirty-sixth week of pregnancy in a prospective randomized study including 100 pregnancies in 97 patients (White's class B, 38; C, 25; D, 28; and F, 9) of which 54 were in the home group and 46 in the hospital group. The duration of pregnancy was not significantly different in two treatment groups, with a median duration of 266.0 days in the home group and 266.5 days in the hospital group. The mean blood glucose values during the study period were 5.9 mmol/L in the home group and 6.0 mmol/L in the hospital group, thus there were no significant group differences. There were no significant group differences in pregnancy complications; however, 10 of 54 (19%) had to interrupt home-monitoring because of pregnancy complications. The perinatal morbidity was not significantly different in the two treatment groups, with the following percentages of complications in the combined series: 4% idiopathic respiratory distress syndrome, 7% transient tachypnea, 2% symptomatic hypoglycemia, 16% hyperbilirubinemia, 22% feeding problems, and 10% erythrocytosis.

Blood Glucose↗
PubMed1984

Immunogenicity of monocomponent human and porcine insulin in newly diagnosed type 1 (insulin-dependent) diabetic children.

The aim of the present study was to compare the immunogenicity of monocomponent human insulin with that of monocomponent porcine insulin in newly diagnosed Type 1 (insulin-dependent) diabetic children. One hundred and thirty-five patients at diagnosis of diabetes (age 1-18 years, mean age 9.3 years) were randomly allocated to treatment with either Monotard MC + Actrapid MC or Monotard HM + Actrapid HM in a double-blind trial conducted in Sweden, Finland, Norway and Denmark. The human and porcine insulin groups were identical at diagnosis with respect to age, sex and measures of metabolic control. At all times the mean insulin antibody levels and the percentage of antibody-positive patients were lower in the human group compared with the porcine group. At 3 and 12 months, the insulin antibody values were significantly lower in the human group than in the porcine group (p less than 0.05, Wilcoxon's rank sum test). At 12 months, antibody values in the human group ranged from 0 to 1.2 U/l (mean 0.14 U/l) and in the porcine insulin group from 0-5.2 U/l (mean 0.63 U/l). It is therefore concluded that human monocomponent insulin has a lower immunogenicity than porcine insulin of the same purity in newly diagnosed diabetic children during the first year of insulin treatment.

Adolescent↗
PubMed1983

Temporary threshold shift after exposure to predicted and unpredicted noise.

In order to investigate if anticipation of noise could influence individual susceptibility to temporary threshold shift (TTS), an experimental study was carried out comprising 10 voluntary normal-hearing subjects. The noise stimulus consisted of noise bursts centered at 4000 Hz with a duration of one second. Initially, each subject was exposed in a test situation where the noise was presented instantly upon the subject's response (producer). The subject was instructed to respond by pressing a button as fast as possible after an optical stimulation. The rate was approximately 1 noise burst/6 sec and the total number of bursts were 100. The intervals between bursts were randomized. Each individual's exposure time pattern was recorded and used for the second test situation. Here the first exposure was reproduced, but each noise burst presented without notice (consumer). Each subject participated in 5 producer sessions and in 5 consumer sessions. Evaluation of TTS measurements revealed a maximum TTS at 6000 Hz. The mean TTS for all subjects in the two different situations, showed no significant difference and only one subject demonstrated a tendency toward a greater TTS susceptibility in the 'consumer' sessions.

Adolescent↗
PubMed1983

The acoustic reflex threshold in relation to noise-induced hearing loss.

In 100 consecutive cases with severe noise-induced hearing loss, pure-tone threshold measurements revealed symmetric hearing losses with maximum shifts at 4000 and 6000 Hz. Acoustic reflex measurements showed that few patients had an elevated pathologic reflex threshold. In contrast, we found a depressed acoustic reflex sensation level (i.e., the difference, in decibels, between pure-tone threshold and acoustic reflex threshold) suggesting a cochlear localization of the injury. Consequently, the probability of retro-cochlear involvement was small, or the cochlear component dominated the retro-cochlear one. The relation between the absence of the acoustic reflex and the degree of hearing loss showed that even at a pure-tone threshold of 80 dB HL, 50% of the ears still had an elicitable acoustic reflex. Statistical analysis yielded a significant correlation between acoustic reflex sensation level and speech discrimination, but no such correlation between acoustic reflex threshold and speech discrimination. We suggest that acoustic reflex sensation level should be a complement to the acoustic reflex threshold in order to distinguish between different localizations of sensorineural hearing losses.

Adult↗
PubMed1981

Sex-reversed XY females with campomelic dysplasia are H-Y negative.

Three families with infants affected with campomelic dysplasia, a genetically determined mesenchymal disease frequently associated with sex reversal were studied. Two XY females with ovarian gonadal differentiation and typical clinical features of campomelic dysplasia could be tested for H-Y antigen and were found to be H-Y negative.

Bone and Bones↗
PubMed1981

Noisy leisure time activities in teenage boys.

An increasing incidence of a high tone hearing loss in teenagers has been demonstrated in recent years. The hearing loss is sensorineural, and looks like an early noise-induced hearing loss with a dip at 6 kHz. It has been discussed whether this is due to noisy leisure time activities or to heredity. Five hundred thirty-eight boys from technical vocational schools were questioned with regard to leisure time activities. Hearing tests showed a normal mean audiogram with a marked dip at 6 kHz. Fifteen percent of the boys showed some hearing loss; more than 20 db HL on one frequency. Many teenagers had noisy leisure time activities, particularly related to pop music. No correlations could be found between hearing loss and the leisure time activities. The only marked correlation was for hearing loss at 4, 6 and 8 kHz on the left ear and a family history of hearing loss. We argue that heredity deficiency could reveal itself as an increased noise sensitivity with a resultant early noise-induced hearing loss at a young age. Much more attention should be devoted to the noisy activities of teenagers.

Adolescent↗
PubMed1981

Early noise-induced hearing loss in teenage boys.

A hearing examination of 538 teenage boys in vocational school classes--implying future on-the-job noise exposure--showed a hearing loss (greater than 20 dB HL at any frequency) in 15% of the cases. Few correlations could be demonstrated between hearing loss and specific leisure time activities. There was, however, a correlation between high frequency hearing loss in the left ear and hereditary hearing loss. The most affected frequency was 6 kHz, suggesting a noise etiology--a suggestion emphasized by the noisy hobbies of these teenagers. It cannot be excluded that a hereditary deficiency could either manifest itself as a localized dip at 6 kHz or reveal itself as an increased vulnerability to noise, identified at young age as a high frequency dip at 6 kHz.

Adolescent↗