PubMed Health⌕ Search

Biomedical subjects

F Lintner

Publications and source records attributed to F Lintner.

At least 37 records · Page 2Linked to original sources
PubMed1992

Circulating antineuronal antibodies reach neurons in vivo: an autopsy study.

In serum and cerebrospinal fluid of 6 out of 15 patients with small cell lung cancer circulating antineuronal antibodies could be detected by indirect immunofluorescence. None of the patients showed signs of a neurological paraneoplastic syndrome, usually associated with the presence of these antibodies. On sections of frontal brain, cerebellum, dorsal root ganglia and peripheral nerve, obtained at autopsy, a direct immunofluorescence test was performed. Only in antibody-positive individuals were membrane-bound immunoglobulin deposits detected on neurons of dorsal root ganglia and Purkinje cells. The present study showed that circulating antineuronal antibodies reach the central and peripheral nervous system in vivo. These findings support the theory that these antibodies might be directly involved in the pathogenesis of neurological paraneoplastic syndromes.

Autoantibodies↗
PubMed1992

Morphometric analysis of cartilaginous tumors.

144 chondromas and chondrosarcomas have been investigated. Morphometry has been performed: the relative volume density of tumor cell nuclei (Vv%n) and the nuclear area have been measured. The results show that the relative volume density of nuclei is a useful parameter, regarding the localisation of the tumors, to discriminate chondromas and chondrosarcomas, while the nuclear area is no safe criterion to separate these entities.

Cell Nucleus↗
PubMed1991

Long-term reaction of the osseous bed around silicone implants.

Between 1970 and 1987, 94 patients received 208 silicone implants at the Department of Orthopaedics, University Hospital, Vienna. Of these, 62.5% were clinically followed up. At follow-up after an average of 116 months, the implant bed was found to be intact in only 41% of cases; in all others we observed lyses around the implant and cysts even in bones at a distance from the operated joint. Histological findings obtained from revision arthroplasty showed a homogeneous picture with foreign-body granulation tissue. These changes were usually clinically inconspicuous and had little effect on patients' subjective well-being. Despite the low discomfort caused, however, the use of such implants in only recommended in critical and severe causes because of the progressive destruction of the osseous bed during the time the implant is in the body.

Adult↗
PubMed1991

Pregnancy in women with chronic renal disease: a 14-year study.

Between 1975 and 1988 authors encountered 44 pregnancies in 26 women who had had chronic renal disease and unimpaired renal function before the conception. Complications during pregnancy and the outcome of pregnancy were studied. There were 5 spontaneous abortions between the 11th and 20th weeks of gestation, 1 therapeutic abortion, 3 still births at weeks 28, 32 and 33, 6 neonatal deaths at age of 26 to 35 weeks, 11 preterm newborns, 35 live births, 9 infants with intrauterine growth retardation including 4 preterm newborns and 1 fetal malformation and 2 cases with premature rupture of the fetal membranes. The pregnancies were complicated with anaemia in 23 cases, with urinary tract infection in 19, with hypertension in 16, with proteinuria in 12 and with edema in 11 cases. Increase in the serum creatinine value during pregnancy was found in 6 cases. These data indicate that the pregnancy in patients with chronic renal disease who had normal renal function before the planned conception, is accompanied with increased risk for both the mother and child.

Adult↗
PubMed1991

Magnesium transport in human pregnancy (magnesium content of human gestation tissues and tissue fluids).

Authors used atom absorption spectrophotometry to determine the magnesium content of gestation tissues (placenta, myometrium) and tissue fluids (maternal blood, cord blood, amniotic fluid) taken in different periods of gestation. Magnesium concentration was found higher in the cord blood than in the maternal serum. It was assumed that the concentration gradient between mother and fetus resulted from active transport. There was a significant difference between the magnesium content of the amniotic fluid and the cord blood sera (P < 0.001). The magnesium content of the mature chorion tissue was by nearly 40% lower than that of the immature one. The magnesium content of the myometrium decreased by 38% by Week 40 of gestation, as compared to the value in Week 37.

Amniotic Fluid↗
PubMed1990

[Role and possibilities of pathology in the diagnosis of osteoporosis].

Iliac crest biopsy and clinical laboratory investigations are the important criteria to diagnose metabolic osteopathies and osteoporosis. The technic of iliac crest biopsy, the histological technic and the histomorphological and histometric criteria will be discussed. The necessity to compare clinical data with the histomorphology and the importance of surgical pathology, especially osteopathology, will be emphasized.

Biopsy↗
PubMed1990

Fibrous metaphyseal defect.

The tendon and ligaments inserted into the perichondrium of the epiphyseal plate were examined in 152 autopsy specimens of tubular long bones. In the region of two areas where tendons were inserted (Ranvier's nodes), the normal medullary tissue is replaced by fibroblastic tissue. A retrospective radiological examination of 155 fibrous metaphyseal defects shows that they are situated at characteristic sites on the circumference of the metaphysis of long tubular bones. This can be related to the insertion of a tendon or ligament near the epiphyseal growth plate which corresponds to areas found in the morphological study and is the site of origin of fibrous metaphyseal defects.

Bone Diseases, Developmental↗
PubMed1989

The influence of fibrin sealant on demineralized bone matrix-dependent osteoinduction. A quantitative and qualitative study in rats.

Allogeneic demineralized bone matrix (DBM) and bone matrix gelatin (BMG) were implanted with or without fibrin sealant (FS) ectopically (abdominal wall) and orthotopically (7-mm trepanation defect) in 38 male Sprague-Dawley rats. Evaluation was done by descriptive histology, histomorphometry of orthotopic implants, and determination of alkaline phosphatase in ectopic implants. The observation period was 21 days with ectopic implantation and 26 days with orthotopic implantation. In all ectopic specimens, new bone developed without any qualitative difference between specimens with and without FS. The alkaline phosphatase activity did not change significantly upon addition of FS. Morphometry revealed slight differences between the groups with and without FS. The peripheral bone deposits in the BMG + FS group, was significantly larger than in the BMG group. These investigations demonstrated neither a clearly positive nor negative effect of FS on ectopic osteoinduction or BMG-dependent osteoregeneration.

Alkaline Phosphatase↗
PubMed1989

Do steroid hormones influence the concentration of PGF2 alpha receptors of the uterine muscles?

Uterine contractions are largely regulated by steroid hormones. The receptors which are important from the point of view of uterine contractions (such as oxytocin, alpha- and beta-adrenergics) are also influenced by steroid hormones. In this paper the regulation by steroids of PG2 alpha receptors was studied in vivo. Due to ovariectomy, the concentration of PG2 alpha decreased significantly in rats without a change in affinity. As a result of in vivo progesterone treatment, the PG2 alpha receptor concentration decreased to its third as compared to that of the ovariectomized control also without a change in affinity. PG2 alpha receptor concentration was not changed by in vivo estrogen treatment in comparison to that of the ovariectomized control but a high-affinity, low-capacity binding-site appeared. Our experiments revealed the in vivo regulation by steroid hormones of the PGW2 alpha receptors of the rat myometrium.

Animals↗
PubMed1988

Reactions of surrounding tissue to the cementless hip implant Ti-6Al-4V after an implantation period of several years. Autopsy studies in three cases.

Three femoral endoprosthetic stems implanted without cement, made of Ti-6Al-4V alloy, with implantation periods of between 2 and 4 years were examined histologically in the form of undecalcified thin ground sections after having been split into segments and embedded in plastic. During the implantation period total osseointegration in the metadiaphyseal region takes place, while in the proximal area reaction forms with direct contact between metal and bone on the one hand and with an interposed membrane of connective tissue and adjacent secondary bony shell on the other must be distinguished. The osseointegration of the stem is the result of a primary healing of the bone and is due to the biocompatibility of the metal alloy and to the primary stability obtained by the press-fit method.

Aged↗
PubMed1988

[Is high-density polyethylene suitable as an implant material in cement-free anchoring of hip endoprostheses? A histomorphologic study of an explanted polyethylene screw-in acetabula].

Firmly attached screw-in polyethylene acetabula which had been implanted for between 16 and 54 months were explanted after autopsies and subjected to macroscopic, radiologic and histologic examination. Metaplasias were seen around the threads and on the floor of the acetabulum. Their tendency to ossify represents an attempt at secondary stabilization. Due to the low stability of the polyethylene this causes increased wear on the floor of the acetabulum. The small defects in the polyethylene found in the threads, resembling damage done by mice, may be a sign of biodegradation. In view of the tissue reactions pointed out, the material stability of the polyethylene needs to be improved or implantation must be restricted to a very limited range of indications.

Acetabulum↗
PubMed1988

[Fibrin gluing of the extraocular eye muscles. Experimental use in the rabbit].

An experimental animal study was conducted to determine whether fibrin glue could be used in strabismus surgery (recession, resection, and muscular neurotization). Fibrin glue was used in place of some or all of the commonly used 7-0 Vicryl sutures. In order to evaluate the adhesion of the fibrin glue the rabbits' eyes were enucleated 10-67 days after surgery, fixed in 8% formalin solution and then histologically examined. In the recession and resection specimens a solid joint between muscles and sclera was found, without any significant scar formation or atrophy of the muscles. The muscular neurotization specimens also exhibited a firm connection between the two muscles, with no abnormal loss of muscle fibers by cicatrization or atrophy. In none of the cases did the conjunctiva show any tendency to conglutination. In view of the simplicity of the fibrin gluing technique and the uniform bonding effect, application in human patients is recommended.

Animals↗
PubMed1988

Irradiation-sterilization of rat bone matrix gelatin.

Bone matrix gelatin induces bone formation in muscle, and when implanted orthotopically it improves bone repair. Co-60 sterilization of bone gelatin impairs the protein-bound induction mechanisms. Gelatin samples nonirradiated or irradiated by 25 or 50 kGy were implanted into a pouch in the abdominal wall of Sprague-Dawley rats, as well as into a 7-mm calvarial defect. Evaluation was done by histologic studies, histomorphometry of orthotopic implants, and determination of alkaline phosphatase in ectopic implants. Gelatin irradiated with 50 kGy was absorbed in the muscle bed without evidence of any specific host reaction. Irradiation of 25 kGy led to histologically confirmed ectopic bone formation, but the wet weight of the explants was only half that of the nonirradiated control samples. Alkaline phosphatase activity was equal in both of these groups. With orthotopic implantation, neither a histologic nor a morphometric effect was seen with 25 kGy. Loss of osteoinduction with 25-kGy irradiation is apparently masked by osteoconductive mechanisms with orthotopic implantation.

Alkaline Phosphatase↗