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Biomedical subjects

F Lithner

Publications and source records attributed to F Lithner.

At least 109 records · Page 6Linked to original sources
PubMed1980

The natural history of stroke in diabetic patients.

A five-year follow-up of 53 diabetic patients admitted for their first stroke in 1972--73 has been performed. They were compared with two groups of 53 non-diabetic patients each with cerebrovascular disease (CVD), one randomly selected and one matched with the diabetics for age, sex and diagnosis of CVD at discharge. All patients could be traced at follow-up. The mean age at the time of first stroke was 66.5 years in male and 73.2 years in female diabetics. Manifest diabetes was diagnosed in 19% during hospitalization for stroke; of the remainder, 74% had had diabetes since less than ten years. In 85% of the diabetics there were no signs of severe angiopathy affecting eyes, kidneys or lower extremities. The majority of diabetic as well as non-diabetic CVD patients had a history of hypertension and/or heart disease. Few were overweight. Case fatality rate was significantly higher in diabetics than in non-diabetics throughout the follow-up (p less than 0.01 for diabetics vs. matched non-diabetics, p less than 0.001 for diabetics vs. randomly selected non-diabetics). The presence of heart disorder predicted mortality in the diabetic subjects. Surprisingly, hypertension diagnosed before stroke involved a more favourable long-term prognosis in all three groups (p less than 0.05). The major causes of death in diabetic CVD patients were cardiac disorders (50%) and stroke (47%). Previous investigations have identified diabetes as a risk factor for stroke. This study shows that diabetes also adversely affects the short-term as well as the long-term outcome in stroke.

Age Factors↗
PubMed1980

Early changes in zinc and copper metabolism in rats with alloxan diabetes of short duration after local traumatization with heat.

Local heat trauma was induced in rats with alloxan diabetes of 3 days duration. Zinc and copper concentrations in serum, liver, heart and pancreas were estimated. After traumatization there was a decrease of the serum zinc concentration in all animals. The lowest concentration was found in the diabetic animals. Serum copper concentrations were lower both in traumatized and nontraumatized diabetic animals compared with controls. The serum copper concentration was slightly lower in traumatized compared with nontraumatized animals in both diabetic animals and controls. In the liver there was an increase of zinc and copper concentration in both groups of traumatized animals, but especially in the diabetic animals. In pancreas there was a decrease in the zinc concentration in traumatized and nontraumatized diabetic animals compared with controls.

Animals↗
PubMed1980

Home monitoring of blood glucose without a photometer.

The ability to estimate blood glucose values at home is an important way of improving diabetic control. In order to investigate whether it was possible to replace the photometers used at present colour discrimination of ReflotestR-Glucose and ReflotestR-Hypoglycemie strips are studied. It was found that a colour scale could be used with one discrete shade of colour for each millimol between 1 to 20 millimol/l. A new test strip Haemo-GlukotestR 20-800 for colour scale usage was tested. Correlation with hexokinase method as reference was found to be r = 0.97.

Blood Glucose↗
PubMed1979

[The diabetic foot].

Explore the source record for details and available documents.

Diabetic Angiopathies↗
PubMed1979

The syndrome of inappropriate secretion of antidiuretic hormone. A case report.

A 72-year-old woman with the syndrome of inappropriate secretion of antidiuretic hormone of unknown cause during more than one year of observation is reported. Plasma vasopressin levels were excessively elevated, even during a water load test. Her serum electrolyte abnormalities and general state were ameliorated after fluid restriction. During treatment with demeclocycline the patient was able to increase fluid without deterioration.

Aged↗
PubMed1979

Local traumatization with heat--cutaneous reactions and early effects on serum zinc concentration in rats with alloxan diabetes of very short duration.

Local heat trauma was induced in rats with alloxan diabetes of 3 days' duration. The cutaneous reaction, water content of the skin and serum zinc concentration were estimated. Petechiae within the area of traumatization were observed more often and were more abundant in the controls than in the diabetic animals. There was no difference between diabetic animals and controls with regard to the increase of water content of traumatized skin or to the water content of non-traumatized skin. There was no difference in serum zinc levels between non-traumatized diabetic animals and controls. After traumatization there was a decrease of serum zinc levels in both animal groups, but to a significantly lower level in the diabetic animals compared to the controls.

Animals↗
PubMed1978

Early cutaneous reactions to local traumatization with heat in alloxan diabetic rats.

The effect of cutaneous traumatization with heat in connection with intravenous injection of Evans blue was studied in short-term alloxan diabetic rats. The effect of traumatization was dependent on the degree of traumatization. There was no difference between diabetic animals and controls. The water content of traumatized and non-traumatized skin was determined. There was no difference between diabetic animals and controls with regard to the increase in water content of traumatized skin. Histological and histochemical studies on the effect of surgical cutaneous traumatization did not reveal any differences between diabetic and non-diabetic animals. The results are compared with earlier observations in alloxan diabetic animals with and without ketosis and in long-term diabetes.

Alkaline Phosphatase↗
PubMed1978

Cutaneous reactions to local traumatization with heat in alloxan diabetic rabbits with and without ketosis.

Short-term alloxan diabetic rabbits with and without ketosis were traumatized with local cutaneous application of heat. The degree of traumatization varied with regard to the temperature and duration used. The lowest degree of traumatization which caused intravenously injected Evans blue to be observed within the area of traumatization was determined. There was no difference between diabetic animals without ketosis and controls. A more pronounced traumatization of animals with ketosis was necessary if Evans blue was to be observed, but there was then a significant difference between these and controls. The traumatized skin areas were also studied histologically. The inflammatory reaction induced was judged as being weaker in animals with ketosis.

Animals↗
PubMed1976

Skin lesions of the legs and feet and skeletal lesions of the feet in familail amyloidosis with polyneuropathy.

Twenty-one patients with familial amyloidosis and polyneuropathy have been examined for the presence of skin lesions, localized to the lower legs and feet. The lesions were classified as atrophic skin lesions, hypertrophic scar-like skin lesions, rubeosis plantarum, spontaneous blisters, necrotic skin lesions, yellow nails, traumatic skin lesions, purpura and abundant pigmented small non-atrophic spots. Skeletal destructions in the feet were also demonstrated. In many respects these lesions are similar to those of long-standing diabetes mellitus. I studied the cutaneous reactions to local thermal trauma with heat and cold to the legs and forearms in 11 patients. Petechiae were observed within the area of traumatization with either heat or cold more often in patients than in controls. Four of the 11 patients developed atrophic circumscribed skin lesions at the site of traumatization.

Adult↗
PubMed1976

Purpura, pigmentation and yellow nails of the lower extremities in diabetics.

This article describes purpura and pigmentations of the lower extremities as well as yellow nails mainly in elderly diabetics but also in persons not known to have diabetes. When the latter were compared to controls, it appeared that their glucose tolerance was altered in a diabetic direction. Precipitating factors could generally be established for these lesions, predominantly cardiac decompensation with edema of the legs, and were more common in patients not known to have open diabetes than in patients with open diabetes. Petechiae were transformed into small, pigmented, non-atrophic spots. Petechiae and pigmented spots were often seen simultaneously. In a few patients small, pigmented, non-atrophic spots were seen as pronounced brown-black pigmentation of the lower legs and feet. In a number of patients with open diabetes or diabetic glucose tolerance, erysipelas with purpura within the area of erysipelas was observed on the lower extremities. Patients with no purpura within the area of erysipelas generally had normal glucose tolerance. The pathogenesis of these lesions is discussed. Atrophic circumscribed skin lesions (Melin), cutaneous erythema, with or without necrosis, purpura, pigmentation, red toes, as well as rubeosis plantarum, yellow nails and neuropathy are often seen simultaneously on the lower extremities of patients with open diabetes as well as of those without open diabetes but with diabetic glucose tolerance.

Aged↗
PubMed1976

Skeletal lesions of the feet in diabetics and their relationship to cutaneous erythema with or without necrosis on the feet.

Seventy patients with cutaneous erythema of the feet with or without necrosis were the subjects of this investigation. Sixty-five of them had open diabetes. The glucose tolerance of the remaining five patients was altered in a diabetic direction. Twenty-seven of the 70 patients had roentgenologically demonstrable destruction in the bones of the feet. These 70 patients were compared with 61 diabetic control patients of corresponding age and duration of diabetes but without these skin lesions of the feet. Only four of the 61 control patients had destruction in the bones of the feet and all these destructions were small. Precipitating factors were identified in general for the skin lesions, the most common being cardiac decompensation. A higher frequency of precipitating factors was seen in patients with skeletal destructions than in those without. The skeletal destructions and cutaneous necrosis are supposed to be equivalent lesions, localized to different tissues in the feet. When patients presenting skin lesions of the feet in the form of distal gangrene were compared with those who had cutaneous erythema and necrosis of the feet, but no distal gangrene, no differences were found with respect to age, duration of diabetes, occurrence of precipitating factors and the occurrence of skeletal destruction. Cutaneous erythema without necrosis is understood to be incipient diabetic gangrene.

Adult↗