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Biomedical subjects

F Lobeck

Publications and source records attributed to F Lobeck.

7 recordsLinked to original sources
PubMed1991

[Behavior of the joint surface of the distal radio-ulnar joint in malposition of the distal radius].

Pathological changes of wrist bones and ligaments after radial fracture loco typico induce permanent functional restriction and pain. In this paper the effects of malunion on the distal radioulnar joint are investigated and osteotomic therapy of Kienböck's disease gets a new evaluation. By simulating radial malunions on anatomic forearm specimen the effects of these malunions on the contact area during supination, neutral position and pronation are measured. Isolated posttraumatic radial shortening as well as epiphyseal inclination and torsion cause a reduction of radioulnar contact. During supination and pronation the loss of radioulnar contact increases. Most significant reduction of contact takes place at a lower graduation of radial malunion. Pronatory torsion of distal radius compensates for a radioulnar contact reduction from combining dorsal inclination with radial shortening. One conclusion of this paper is an exact restitution of anatomical relations between ulnar head and radial notch after fracture of the distal radius.

Biomechanical Phenomena↗
PubMed1988

A review of lithium dosing methods.

Lithium's narrow therapeutic range, concentration-effect relationship, and large differences in interindividual disposition make it an attractive candidate for predictive dosing methods. Lithium disposition is influenced by a number of factors, including patient characteristics, renal function, and concomitant drug therapies. These factors are accounted for, in varied degrees, in the different dosing methods available. One a priori method takes many of these factors into account and appears to have better reliability than others that ignore nonrenal influences on lithium disposition. The lack of data on pharmacokinetic values in different populations limits the usefulness of many of the single-point methods. Better data on the disposition of lithium in differing populations would greatly enhance the utility of both the a priori and single-point methods. Several multipoint methods, which estimate an individual's pharmacokinetic values, have also been described. These appear to be the most reliable, although they are time consuming and may delay the initiation of therapy. A well-designed Bayesian approach to the dosing of lithium, although not currently available, would be the most useful.

Dose-Response Relationship, Drug↗
PubMed1988

Clinical outcome and adverse effect profile associated with concurrent administration of alprazolam and imipramine.

Clinical outcome and adverse effects associated with concurrent alprazolam and imipramine administration were studied in 29 patients with major depressive disorder who completed a 6-week trial in which they served as their own controls. Alprazolam was added on Day 8 in gradually escalating, then gradually tapering dosages while imipramine dosages remained unchanged. Significant decreases were observed in scores on the Hamilton Rating Scales for Depression and Anxiety at all later evaluation days with Day 8 as baseline. The mean total Symptom and Side Effects score decreased significantly from Day 8 to Day 22 when alprazolam doses were 1 mg q.i.d. For most side effects, total number of reports remained constant or decreased from Day 1 to later evaluation days. Standing diastolic blood pressures were significantly lower on Day 22 than on Day 1. No significant relationship was found between any rating scale score and plasma concentration data.

Adult↗