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F Lorente Toledano

Publications and source records attributed to F Lorente Toledano.

13 recordsLinked to original sources
PubMed1992

[Evaluation of plasma zinc levels in patients with Down syndrome].

Using the atomic absorption spectroscopy technique, the plasma concentrations of zinc were measured in 32 patients with Down's syndrome (DS) and in 44 healthy controls (C). An obvious and significant decrease in the levels of this element was observed in the trisomic subjects (DS:124.5 +/- 21.7 micrograms/dl; C:150.3 +/- 28 micrograms/dl). Additionally, there seemed to be no relationship or dependence between this observation and the age or the institutionalization of these patients. From a detailed analysis of the population studied, it is inferred that together with personal antecedents of repeated infections, there is always a deficit in this element. It is possible that this deficiency might be due to an activation of the zinc dependent enzymatic systems involved in the immune response.

Adolescent↗
PubMed1981

[Immunological diagnosis of collagen diseases and rheumatoid arthritis (author's transl)].

Most helpful immunological tests for diagnosis of connectivities are revised. Among them, antinuclear antibodies (AAN) are the most important. They are usually detected by immunofluorescence and show different patterns, being the peripheral one the most specific of SLE and it is related with antibodies anti-DNA which can make immunocomplexes DNA-anti-DNA and be the cause of lupic nephropathy. The "nucleolar" and "speckled" patterns are more frequent in scleroderma. The LE cells have less value than AAN. The rheumatoid factor is a IgM antibody anti-IgG, but also can be of IgG or IgA class. It is uncommon in the juvenile rheumatoid arthritis of systemic onset and more frequent in oligoarticular adult type. May became positive during disease evolution. Other factors as immunoglobulin of complement usually are increased, except when the activation of complement take place. Acute phase reactants are helpful just for evaluating the importance of inflammation, they have not diagnosis value and commonly do not exceed the value of erythrocyte sedimentation rate.

Antibodies, Antinuclear↗
PubMed1981

[Immunological pathogenesis of collagenosis].

The present paper contains an analysis of the essential factors which combine in the pathogeny of autoimmune illnesses, using Systemic Erythematous Lupus as a prototype. These patients present a hyperfunction of B lymphocytes due to either an intrinsic defect of these cells or disorders in the cells which regulate them which is translated into a high response to nuclear and lymphocytary antigens. The formation of circulating immunocomplexes in these patients would be responsible for the inflammatory vascular and tissue lesions which they present when the Complement is deposited and activated. The antilymphocyte antibodies affect both the B as well as T lymphocytes, by activating the former and destroying the latter particularly the underpopulation of suppressing T lymphocytes. This is translated into a greater activity of the cells which produce antibodies.

Animals↗
PubMed1978

[Thymus implant in a case of DiGeorge syndrome (author's transl)].

A boy with III-IV pharingeal pouch malformative syndrome, hypocalcemia and recurrent infections is presented. The immunological work-up disclosed deficiency in the specific cellular immunity with normal serum immunoglobulin levels. An adult thymus in Millipore diffusion chambers was implanted in the rectus adominalis muscle. One week later clinical and analytical data suggesting immunological reconstitution was recorded. Two years later the patient remains in good health, T and B lymphocyte percentages are normal, being the only immunological abnormality a low serum level of IgG.

DiGeorge Syndrome↗
PubMed1977

[Nezelof syndrome with secondary immunodeficiency (author's transl)].

A child with recurrent infections is presented. The frequent diarrhea leads to a severe malnutrition. The immunological work-up disclosed: absent IgA and low IgG serum levels, deficient cellular immunity and abnormal neutrophil chemotaxis. The cellular immunity and the neutrophil chemotaxis were improved with the nutritional status. At present the patient shows a partial combined immunodeficiency. The diagnosis of the case as a Nezelof's syndrome is discussed, as well as the addition of a secondary immunodeficiency caused by the recurrent infections and the malnutrition.

Adolescent↗
PubMedDate not supplied

[Common variable immunodeficiency (author's transl)].

In a boy initially diagnosed as X-linked hypogammaglobulinemia, the later clinical and analytical course and the application of new immunological techniques led to the new diagnosis of common variable immunodeficiency. The patient shows panhypogammaglobulinemia, a scarce number of plasma cells with a normal number of precursors and circulating B lymphocytes with membrane bound immunoglobulins and C3 receptors. Delayed hypersensitivity is absent despite normal amount of circulating T lymphocytes which were able to transform when stimulated by PHA. The anergy seems primary and not related to the clinical malnutrition. The authors make a differential diagnosis between both illnesses as a tentative pathogenetic interpretation of B cell development arrest.

Agammaglobulinemia↗
PubMedDate not supplied

A study of the functions of polymorphonuclear neutrophil in patients with Down's syndrome.

Patients with Down's syndrome (DS) are predisposed to infectious diseases, particularly of the respiratory tract. Together with the occurrence of cardiac defects, this is one of the main determinants of their life expectancy. The aim of the present work was to study a series of immunological parameters that would allow us to evaluate the functional behaviour of the neutrophil polymorphonuclears of the patients with trisomy 21 and the possible relationship between this and the susceptibility of this kind of patient to such infections. The results obtained point a significant decrease (p less than 0.001) in the adhesiveness index and in the two indexes relating to the evaluation of random mobilities of cells ("leading front" and "lower face of filter"). Although the neutrophil chemotactic responsiveness of these patients is decreased with any of the attractants employed (casein and activated sera), the differences observed with respect to the control population are more patent upon analyzing the function on the "lower face of filter". Study of phagocytosis of Candida albicans and candidicidal activity of PMN reveals a normal behaviour in the presence of autologous (patient) and heterologous (control) serum. We propose that the alterations found in the PMN cell functions of DS patients could be due to intrinsic cellular defects and that this would help to explain why such patients tend to undergo repetitive infective processes.

Cell Adhesion↗
PubMedDate not supplied

[Evaluation of the immune system in Down's syndrome patients].

The authors carry out a study to evaluate the immunoglobulin and complement factor levels and the populations and subpopulations of mononuclear cells enumerated by monoclonal antibodies, in Down's syndrome (DS) patients. The IgG, IgA and IgM immunoglobulins were significantly increased, and presented an age-dependence. The complement factors, C3 and C4 were normal. We enumerated T lymphocyte subsets in these patients using OKT3, OKT4, OKT6, OKT8, OKIa1 and OKM1 monoclonal antibodies. The percentages of total T cells (T3 + cells) and of helper T lymphocytes (T4 + cells), were significantly decreased (DS: 49 +/- 11%; p less than 0,05) (DS: 20 +/- 7%; p less than 0,001); nevertheless in the subpopulations of suppressor/cytotoxic T lymphocytes, we found an increase (T8 + cells) (DS: 34 +/- 12%; p less than 0,01). In the remainder of the populations studied, B lymphocytes, monocytes, null-cells and common thymocytes no apparent alterations were detected. The study has shown an imbalance between populations of helper induced and cytotoxic /suppressor T lymphocytes in these patients. It appears that the unbalances in population and subpopulation studies could be due to an alteration of the Thymus. This is suggested by the increased susceptibility to polytopic infections, high risk of malignancies and high frequency of autoantibodies.

Adolescent↗
PubMedDate not supplied

Monocyte functional defects in rheumatoid arthritis.

Monocytes derived from peripheral blood of patients with rheumatoid arthritis (RA) had a marked defect in their chemotactic and phagocytic activity. The chemotactic defect resides at a cellular level, while the phagocytic defect is serum-dependent. Both defects could be of importance in the pathogenicity of RA and the susceptibility to infection such patients show. Finally, monocytes were found to have a negative influence over spontaneous cytotoxicity mediated by T lymphocytes.

Arthritis, Rheumatoid↗