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Biomedical subjects

F M Baer

Publications and source records attributed to F M Baer.

At least 37 records · Page 2Linked to original sources
PubMed2000

[Magnetic resonance tomography in clinical cardiology].

Magnetic resonance imaging (MRI) has become a well-established method for the diagnosis of diseases of the heart and the great vessels. Almost 20% of all patients cannot be completely examined by transthoracic echocardiography. In this patient group, MRI can be used as a second line technique to provide important diagnostic information not obtainable by echocardiography. However, there are clinical problems for which MRI may be used as the first line technique such as complex congenital heart disease, diseases of the great vessels, pericardial disease or cardiac tumors. MRI is undergoing rapid technical improvement and this will further improve the diagnostic utility of the technique, especially in patients with coronary artery disease.

Cardiovascular Diseases↗
PubMed2000

Long-term follow-up of 82 patients with chronic disease of the thoracic aorta using spin-echo and cine gradient magnetic resonance imaging.

The objective of this study to examine the clinical impact of magnetic resonance imaging in long-term follow-up of patients (pts) with chronic disease of the thoracic aorta such as coarctation of the aorta, chronic aortic dissection and true aortic aneurysm. A total of 322 magnetic resonance examinations obtained in 82 pts with chronic disease of the thoracic aorta (31 pts with coarctation of the aorta (CoA), 29 pts with chronic aortic dissection and 22 pts with true aneurysm) over a period of 0.25 to 13.5 (mean +/- SD: 6.5 +/- 3.4) years were retrospectively reviewed. Diameters of the thoracic aorta were measured at predefined levels and morphological and functional parameters of special interest were analysed in each patient group. Pts were classified as having constant or progressive disease and clinical end-points were defined as (re-)operation or death. 43 pts (52%) (CoA 15 pts, chronic dissection 16 pts, true aneurysm 12 pts) had constant findings. None of them underwent (re-)operation and seven patients (16%) died, three of them from their aortic disease more than five years later after their last magnetic resonance examination, one from an arrhythmogenic event, and in the remaining 3 pts the cause of death could not be definitely established. 39 pts (48%) (CoA 16 pts, chronic dissection 13 pts, true aneurysm 10 pts) had progressive disease as demonstrated by repetitive magnetic resonance imaging. Of these 39 pts 24 pts underwent (re-)operation, in 15 pts operation was postponed. Four pts died from their aortic disease. Repetitive magnetic resonance imaging is a clinically feasible technique for long-term follow-up of pts with chronic disease of the thoracic aorta because it can detect progressive disease in a large subset of pts requiring elective surgery. The results of magnetic resonance imaging provided the rationale for either (re-)operation or conservative management, thus guiding patient management.

Adolescent↗
PubMed2000

Head to head comparison of dobutamine-transoesophageal echocardiography and dobutamine-magnetic resonance imaging for the prediction of left ventricular functional recovery in patients with chronic coronary artery disease.

AIMS: A substantial number of patients with dysfunctional but potentially viable myocardium cannot be accurately evaluated by transthoracic echocardiography due to a poor acoustic window. This study compares the diagnostic value of alternative functional imaging techniques, such as dobutamine-transoesophageal echocardiography (dobutamine-TEE) and dobutamine magnetic resonance imaging (dobutamine-MRI) for the detection of viable myocardium and the prediction of left ventricular functional recovery in patients with chronic coronary artery disease following successful revascularization procedures. METHODS AND RESULTS: Rest and low-dose (5, 10 microg dobutamine x min(-1) x kg(-1)) multiplane dobutamine-TEE and ultrafast cine-MRI studies were performed in 103 patients. Contractile recovery of an infarct region was predicted if a dobutamine contraction reserve could be assessed visually by TEE or MRI in > or =50% of infarct-related a- or dyskinetic segments. Revascularization of the infarct-related vessel was successful in 88 patients, and 4.9 +/- 0.7 months later 52 patients still had an angiographically controlled open target vessel. These patients underwent another rest MRI study to assess left ventricular functional recovery. A dobutamine contraction reserve was observed in 27/52 (52%) patients by TEE and in 26/52 (50%) patients by MRI. Functional improvement of the infarct region was diagnosed in 28/52 (54%) patients. The positive and negative predictive accuracy of dobutamine-TEE and dobutamine-MRI for the prediction of left ventricular functional recovery was not significantly different (85% vs 92%, ns and 80% vs 85%, ns). Diagnosis of a predominantly viable infarct region by TEE and MRI predicted a significant increase in left ventricular ejection fraction (TEE: 12 +/- 8% vs 2 +/- 7% P<0.001, MRI: 13 +/- 7% vs 2 +/- 7%, P<0.001) compared to infarct regions graded as scar. CONCLUSION: A qualitative visual analysis of TEE and MRI viability studies is highly accurate for the prediction of left ventricular functional recovery in patients with dysfunctional myocardium and proved to be a clinically valuable alternative if transthoracic dobutamine-echocardiography is unsuitable. To date, TEE is cardiologists' preferred choice for the assessment of myocardial viability but MRI may become significantly more attractive with increasing local availability and experience.

Aged↗
PubMed1999

[Clinical value of magnetic resonance tomography in imaging coronary stenoses. A comparison with coronary angiography and myocardial scintigraphy].

BACKGROUND AND OBJECTIVE: The development of ultra-rapid gradient-echo sequence magnetic resonance imaging (MRI) makes it possible to visualize coronary arteries. But the clinical value of coronary artery MRI (MRCA) still needs to be established. It was the aim of this study to determine whether MRCA can demonstrate proximal parts of the coronary arteries and visualize haemodynamically relevant stenoses. PATIENTS AND METHODS: MRCA was performed, using segmented 2D sequences and a navigator pulse, in 29 patients (22 men, seven women, mean age 60 +/- 10 years) in whom coronary heart disease (CHD) was suspected or who, with proven CHD (> or = 50% stenosis) further treatment was to be established. Exercise myocardial scintigraphy with single proton emission tomography (SPECT) was additionally performed in 20 of the patients. RESULTS: Seven of 87 coronary arteries (8%) could not be demonstrated because the patients' claustrophobia necessitated premature termination of the investigation: these vessels were excluded from the final analysis. The mean length of the visualized coronary arteries was 12 +/- 4 mm for the main stem (LM), 36 +/- 14 mm for the left interventricular branch (LAD), 18 +/- 12 mm for the circumflex branch (CX) and 67 +/- 23 mm for the right coronary artery (RCA). Of 37 stenoses demonstrated by coronary angiography 29 were also visualized by MRCA: 13 of 18 LAD stenoses, two of three CX stenoses and 14 of 16 RCA stenoses. Mean sensitivity of MRCA was 78%, mean specificity 86%. In patients who had undergone exercise SPECT, coronary angiography demonstrated 26 stenoses, of which 16 (six LAD, two CX and eight RCA stenoses) were haemodynamically significant. Of these 16 stenoses MRCA demonstrated 13, but three stenoses (one RCA and two LAD stenoses) were not visualized, because the stenoses were distal to the demonstrated segments. CONCLUSION: MRCA can visualize moderately severe stenoses, especially of the proximal coronary arterial segments. This method represents an new approach to noninvasive diagnosis of CHD, but additional technical improvements will have to be made.

Adult↗
PubMed1999

[Dissection of the ramus interventricularis anterior in blunt chest trauma].

HISTORY AND ADMISSION FINDINGS: A 57-year-old man suffered a blunt trauma to his chest when the car he was driving collided head-on with a stationary lorry. He had worn his seat belt and the air-bag had inflated on impact. He was admitted to hospital because of severe left chest pain that started 45 min after the accident. Admission physical examination indicated stable cardiopulmonary status in a fully conscious person with no obvious physical signs, in particular no contusion or other injury to the chest or fractures. INVESTIGATIONS: ECG, echocardiography, chest radiography and routine laboratory tests on admission failed to reveal any diagnostic abnormality. But subsequent ECG and biochemical tests suggested evolution of an acute anterior wall infarction, leading to the patient's transfer to the author's hospital. DIAGNOSIS AND TREATMENT: A coronary angiogram revealed traumatic dissection of the anterior interventricular branch (AIVB) around the origin of the first diagonal branch. There was also suspicion of thrombus formation and clearly impaired left ventricular function with hypo- to akinesia of the anterior wall. Myocardial scintigraphy, positron emission tomography and stress echocardiography were performed to assess the possible need for interventional or surgical revascularization. They demonstrated functioning myocardial tissue in most of the anterior wall so that minimally invasive AIVB-bypass operation was planned. CONCLUSION: The possibility of severe injury of the heart and other organs even after primarily blunt chest trauma demands careful follow-up monitoring and, if indicated, extensive noninvasive as well as invasive diagnosis and treatment.

Accidents, Traffic↗
PubMed1999

Stress functional MRI: detection of ischemic heart disease and myocardial viability.

Breath-hold gradient-echo magnetic resonance imaging (MRI) in conjunction with pharmacologic dobutamine stress has become a practical tool to investigate patients with chest pain. The presence of high-grade coronary artery stenoses can be detected more accurately than with stress echocardiography. The main diagnostic advantage of MRI is in patients with suboptimal echocardiographic image quality. Depiction of left ventricular anatomy and function at rest and during low-dose dobutamine stress is also clinically useful for evaluating patients with severely impaired left ventricular function for the presence of residual myocardial viability. Recovery of regional and global left ventricular function can be accurately predicted by stress functional MRI. J. Magn. Reson Imaging 1999;10:667-675, 1999.

Cardiotonic Agents↗
PubMed1999

Improvement of myocardial blood flow to ischemic regions by angiotensin-converting enzyme inhibition with quinaprilat IV: a study using [15O] water dobutamine stress positron emission tomography.

OBJECTIVES: This study was designed to analyze the effects of acute angiotensin-converting enzyme (ACE) inhibition on myocardial blood flow (MBF) in control and ischemic regions. BACKGROUND: Although animal studies indicate an improvement of MBF to ischemic regions after ACE inhibition, this effect has not been conclusively demonstrated in patients with coronary artery disease. METHODS: Myocardial blood flow was analyzed in ischemic and nonischemic regions of 10 symptomatic patients with coronary artery disease using repetitive [15O] water positron emission tomography at rest and during maximal dobutamine stress before and after ACE inhibition with quinaprilat 10 mg i.v. To exclude the possibility that repetitive ischemia may cause an increase in MBF, eight patients underwent the same protocol without quinaprilat (placebo patients). RESULTS: Rate pressure product in control and quinaprilat patients was comparable. In placebo patients, repetitive dobutamine stress did not change MBF to ischemic regions (1.41 +/- 0.17 during the first stress vs. 1.39 +/- 0.19 ml/min/g during the second stress, p = 0.93). In contrast, MBF in ischemic regions increased significantly after acute ACE inhibition with quinaprilat during repetitive dobutamine stress (1.10 +/- 0.13 vs. 1.69 +/- 0.17 ml/min/g, p < 0.015). Dobutamine coronary reserve in ischemic regions remained unchanged in placebo patients (1.07 +/- 0.11 vs. 1.10 +/- 0.16, p = 0.92), but increased significantly after quinaprilat (0.97 +/- 0.10 vs. 1.44 +/- 0.14, p < 0.002). Total coronary resistance decreased after ACE inhibition (123 +/- 19 vs. 71 +/- 10 mm Hg x min x g/ml, p < 0.02). CONCLUSIONS: Angiotensin-converting enzyme inhibition by quinaprilat significantly improves MBF to ischemic regions in patients with coronary artery disease.

Adult↗
PubMed1998

Significance of exercise-induced ST-segment elevation and T-wave pseudonormalization for improvement of function in healed Q-wave myocardial infarction.

Exercise-induced ST-segment elevation and pseudonormalization of negative T waves (ST-T segment changes) in infarct leads indicate myocardial viability after Q-wave myocardial infarcts in some patients and may therefore identify patients who will benefit from revascularization. Global left ventricular ejection fraction and wall motion abnormalities of the left ventricle were analyzed in 34 patients with healed myocardial infarction (11 patients with ST-segment elevation, 3 patients with pseudonormalization of the negative T wave (group 1), and in 20 patients without ST-T segment changes during an exercise electrocardiogram (group 2)) before and 4 months after successful revascularization. Wall motion abnormality in the central infarct region at baseline was similar in both groups (-3.1 +/- 0.6 SD vs 3.0 +/- 0.8 SD; NS). At repeat angiography, wall motion abnormality improved significantly from -3.1 +/- 0.6 SD to -2.1 +/- 0.6 SD (p <0.01) in group 1 and was unchanged in group 2 (-3.0 +/- 0.8 SD vs -2.9 +/- 0.7 SD; NS). Similarly, ejection fraction at control angiography had increased from 54 +/- 14% to 66 +/- 12% (p <0.01) in group 1, but decreased from 56 +/- 9% to 55 +/- 9% in group 2 (NS). Exercise-induced ST-T segment changes yielded a sensitivity of 80% and a specificity of 89% to predict significant improvement of the left ventricular ejection fraction. Exercise-induced changes of the ST-T segment identify patients with a high probability of improvement of myocardial function after revascularization in patients with healed myocardial infarcts.

Adult↗
PubMed1998

Dobutamine magnetic resonance imaging predicts contractile recovery of chronically dysfunctional myocardium after successful revascularization.

OBJECTIVES: This study sought to evaluate whether myocardial viability, as assessed by magnetic resonance imaging (MRI), reliably predicts postrevascularization left ventricular (LV) recovery. BACKGROUND: Compared with positron emission tomographic findings, MRI has proved to be a reliable technique for the identification of residual myocardial viability. However, the predictive accuracy of MRI-assessed preserved end-diastolic wall thickness (DWT) and dobutamine-induced systolic wall thickening (SWT) for LV functional recovery has not yet been evaluated. METHODS: Rest and low dose dobutamine MRI was performed in 43 patients with a chronic infarct (> or =4 months since ischemic event) and LV dysfunction who had undergone revascularization of the infarct-related vessel. On the basis of segmental evaluation of corresponding short-axis tomograms, infarct regions were graded viable by MRI if 1) DWT was > or =5.5 mm, and 2) dobutamine-induced SWT was > or =2 mm in > or =50% of dysfunctional segments related to the infarct region. Functional recovery was defined as SWT > or =2 mm in > or =50% of infarct-related segments at rest 4 to 6 months after successful revascularization. RESULTS: Recovery of regional SWT could be observed in 27 (63%) of 43 patients. Comparison MRI grading before and after revascularization indicated that dobutamine-induced SWT was a better predictor of LV functional recovery (sensitivity 89%, specificity 94%) than was preserved DWT (sensitivity 92%, specificity 56%). Segments that remained akinetic after revascularization had significantly lower DWT (6.0+/-3.1 mm [n = 219] vs. 9.8+/-2.6 mm [n = 188], p < 0.001) than those with improved SWT. Left ventricular ejection fraction increased significantly in patients with dobutamine-induced SWT than in those with no contractile reserve (14+/-9% vs. 3+/-9%, p < 0.0002), and the magnitude of this increase was correlated with the number of dobutamine-responsive segments per infarct region (r = 0.68, p < 0.0001). CONCLUSIONS: Quantitative assessment of dobutamine-induced SWT in chronic infarcts by MRI is a highly accurate predictor of LV functional recovery, and the presence of significantly reduced DWT reliably indicates irreversible myocardial damage. Therefore, dobutamine stress testing for the assessment of myocardial viability can be restricted to patients with preserved DWT.

Adult↗
PubMed1998

Significance of rest technetium-99m sestamibi imaging for the prediction of improvement of left ventricular dysfunction after Q wave myocardial infarction: importance of infarct location adjusted thresholds.

OBJECTIVE: The value of rest technetium-99m (Tc-99m) sestamibi scintigraphy under oral nitrate medication to predict myocardial viability was examined in patients with chronic infarcts. BACKGROUND: The value of rest Tc-99m sestamibi to predict viability in infarct regions has not been fully established because significant underestimation of viability, especially in the inferior myocardial wall, has been reported. METHODS: Forty patients with Q wave myocardial infarction underwent Tc-99m sestamibi single-photon emission computed tomography under nitrate medication before revascularization of the infarct-related artery. Wall motion was quantified from paired angiograms before and 4 months after revascularization. Tracer uptake was quantified in the central infarct region identified on the angiogram. RESULTS: The average Tc-99m sestamibi uptake in the central infarct region of patients with anterior infarcts and improvement of left ventricular function was significantly higher (68+/-12%, mean+/-SD) than in patients without improvement of function (40+/-14%, p < 0.02). The average Tc-99m sestamibi uptake in the central infarct region of patients with improvement of function and inferior infarcts was significantly lower (43+/-7%) than in patients with anterior infarcts (68+/-12%, p < 0.003), but was significantly higher than in patients with inferior infarction and no improvement of function (31+/-7%, p < 0.02). Using an infarct location adjusted optimal threshold (50% for anterior infarcts, 35% for inferior infarcts), Tc-99m sestamibi had a positive predictive value of 90% and a negative predictive value of 91% for improvement of left ventricular function. CONCLUSION: Quantitative rest Tc-99m sestamibi scintigraphy after oral nitrates reliably predicts improvement of left ventricular function after revascularization if infarct location adjusted thresholds are used.

Aged↗
PubMed1998

Accuracy and feasibility of contrast echocardiography for detection of perfusion defects in routine practice: comparison with wall motion and technetium-99m sestamibi single-photon emission computed tomography. The Nycomed NC100100 Investigators.

OBJECTIVES: We sought to assess the feasibility and accuracy of myocardial contrast echocardiography (MCE) using standard imaging approaches for the detection of perfusion defects in patients who had a myocardial infarction (MI). BACKGROUND: Myocardial contrast echocardiography may be more versatile than perfusion scintigraphy for identifying the presence and extent of perfusion defects after MI. However, its reliability in routine practice is unclear. METHODS: Fundamental or harmonic MCE was performed with continuous or triggered imaging in 203 patients with a previous MI using bolus doses of a perfluorocarbon-filled contrast agent (NC100100). All patients underwent single-photon emission computed tomography (SPECT) after the injection of technetium-99m (Tc-99m) sestamibi at rest. Quantitative and semiquantitative SPECT, wall motion and digitized echocardiographic data were interpreted independently. The accuracy of MCE was assessed for detection of segments and patients with moderate and severe sestamibi-SPECT defects, as well as for detection of patients with extensive perfusion defects (>12% of left ventricle). RESULTS: In segments with diagnostic MCE, the segmental sensitivity ranged from 14% to 65%, and the specificity varied from 78% to 95%, depending on the dose of contrast agent. Using both segment- and patient-based analysis, the greatest accuracy and proportion of interpretable images were obtained using harmonic imaging in the triggered mode. For the detection of extensive defects, the sensitivity varied from 13% to 48%, with specificity from 63% to 100%. Harmonic imaging remained the most accurate approach. Time since MI and SPECT defect location and intensity were all determinants of the MCE response. The extent of defects on MCE was less than the extent of either abnormal wall motion or SPECT abnormalities. The combination of wall motion and MCE assessment gave the best balance of sensitivity (46% to 55%) and specificity (82% to 83%). CONCLUSIONS: Although MCE is specific, it has limited sensitivity for detection of moderate or severe perfusion defects, and it underestimates the extent of SPECT defects. The best results are obtained by integration with wall motion. More sophisticated methods of acquisition and interpretation are needed to enhance the feasibility of this technique in routine practice.

Contrast Media↗
PubMed1998

Methods of assessment and clinical relevance of myocardial hibernation and stunning. Assessment of myocardial viability.

During the past decade there has been intense clinical interest in the differentiation between scar tissue and postischemic viable myocardium and its relevance to patient treatment and outcome. Frequently used paradigms of myocardial viability are hibernation and stunning which both refer to reversible left-ventricular contraction impairment. Hibernation describes the concomitant reduction of myocardial perfusion and contractility, whereas stunning characterizes contractile impairment persisting for some time after perfusion has been restored. In the clinical setting ischemia, stunning, hibernation, and necrosis may coexist. A variety of imaging techniques encompassing a wide range of physiologic entities such as contractile function, perfusion, membrane integrity and cell metabolism are currently in use to differentiate between these conditions, and they allow an accurate decision making with respect to revascularization procedures or conservative management. This article reviews current concepts and diagnostic methods to assess viable myocardium, and it attempts to address the clinical relevance of revascularization procedures in patients with coronary artery disease harboring dysfunctional but viable myocardium.

Cell Survival↗
PubMed1997

QT dispersion is determined by the extent of viable myocardium in patients with chronic Q-wave myocardial infarction.

BACKGROUND: QT dispersion is lower in patients with successful thrombolysis after acute myocardial infarction, suggesting that QT dispersion may be determined by the extent of viable and scarred myocardium. METHODS AND RESULTS: To test this hypothesis, QT dispersion was measured in a 12-lead resting ECG in 44 patients with chronic Q-wave myocardial infarction. To assess the extent of viable and scarred myocardium, all patients underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET). In addition, all patients had revascularization of the infarct-related artery and repeated angiography 4 months later. QT dispersion was lower (53+/-20 versus 94+/-24 ms, P<.0001) in patients with evidence of a substantial amount of viable myocardium in the infarct region as demonstrated by PET (average FDG uptake > or = 50% of normalized, maximum FDG uptake) than in patients with only minimal residual viability. Average FDG uptake of the infarct region and FDG defect size were significantly related to QT dispersion (r=.64, P<.0001; r=.67, P<.0001), whereas ejection fraction was not (r<.1, P=NS). QT dispersion of < or = 70 ms had a sensitivity of 85% and a specificity of 82% to predict viable myocardium in the infarct region. QT dispersion was also lower in patients with improvement of left ventricular function 4 months after revascularization (54+/-21 versus 88+/-30 ms, P=.0003). QT dispersion of < or = 70 ms had a sensitivity of 83% and a specificity of 71% to predict improvement of left ventricular function. CONCLUSIONS: QT dispersion is determined by the amount of viable myocardium in the infarct region and may serve as a novel, rapidly available marker of substantial viability in the infarct region of patients with chronic Q-wave myocardial infarction.

Angioplasty, Balloon, Coronary↗
PubMed1996

Comparison of dobutamine transesophageal echocardiography and dobutamine magnetic resonance imaging for detection of residual myocardial viability.

A dobutamine-induced contraction reserve in akinetic but viable myocardium, observed by echocardiography or magnetic resonance imaging (MRI), is a reliable indicator of myocardial viability. However, the comparative diagnostic accuracy of these 2 techniques is unknown. Therefore, 43 patients with myocardial infarction (infarct age > or = 4 months) and regional akinesia underwent dobutamine transesophageal echocardiography (TEE) and dobutamine MRI (10 microg dobutamine/ min/kg). Both imaging techniques were compared with the reference standard 18F-fluorodeoxyglucose positron emission tomography (FDG PET). An infarct region was considered viable if a dobutamine contraction reserve could be assessed visually by TEE or quantitatively by MRI in > or = 50% of segments graded "a" or dyskinetic at rest. Infarct regions were graded viable by PET if FDG uptake was > or = 50% of the maximal FDG uptake in a region with normal wall motion by left ventriculography. A dobutamine contraction reserve was found in 21 of 43 patients (49%) by TEE and MRI. A viable infarct region by FDG PET was diagnosed in 26 of 43 patients (60%). FDG uptake and dobutamine TEE were concordant in 36 of 43 patients (84%) and dobutamine MRI and FDG PET were concordant in 38 of 43 patients (88%). Sensitivity and specificity of dobutamine TEE and dobutamine MRI for FDG PET-defined myocardial viability were 77% versus 81% and 94% versus 100%, respectively. Both imaging techniques yielded similar results for the detection of myocardial viability as defined by FDG uptake, with a slightly higher sensitivity and specificity for the quantitatively evaluated dobutamine contraction reserve by MRI.

Adrenergic beta-Agonists↗
PubMed1996

Predictive value of low dose dobutamine transesophageal echocardiography and fluorine-18 fluorodeoxyglucose positron emission tomography for recovery of regional left ventricular function after successful revascularization.

OBJECTIVES: This study was designed to assess the predictive value of myocardial viability diagnosed by dobutamine transesophageal echocardiography and fluorine (F)-18 fluorodeoxyglucose positron emission tomography for left ventricular functional recovery after revascularization in patients with chronic left ventricular dysfunction. BACKGROUND: The identification of akinetic but viable myocardium is of particular importance for the selection of patients with a compromised left ventricle who will benefit from coronary revascularization. METHODS: Multiplane rest and dobutamine transesophageal echocardiography (dobutamine, 5 and 10 microg/min per kg) studies and F-18 fluorodeoxyglucose positron emission tomographic studies at rest were performed in 2 patients with 1) previous myocardial infarction and regional akinesia, 2) a stenosed infarct-related coronary artery, and 3) a patent infarct-related vessel after revascularization. A basally akinetic segment was considered viable by transesophageal echocardiography if dobutamine-induced contractile reserve could be observed. Viability by positron emission tomography was defined as F-18 fluorodeoxyglucose uptake > or = 50% of the maximal uptake in a region with normal wall motion. Recovery of regional left ventricular function 4 to 6 months after revascularization was diagnosed by transesophageal echocardiography if > or = 50% of segments akinetic at baseline had improved wall thickening. RESULTS: Dobutamine transesophageal echocardiography identified viable infarct regions in 25 (59%) of 42 patients, and F-18 fluorodeoxyglucose positron emission tomography in 30 (71%) of 42 patients, yielding diagnostic agreement in 86% of patients. Sensitivity and specificity for prediction of left ventricular functional recovery in individual patients was 92% and 88%, respectively, for dobutamine transesophageal echocardiography versus 96% and 69% for F-18 fluorodeoxyglucose positron emission tomography. Segments remaining akinetic after revascularization had a significantly lower (p < 0.001) F-18 fluorodeoxyglucose uptake (48 +/- 15%) than that (73 +/- 15%) of segments with recovery of regional left ventricular function. CONCLUSIONS: Both dobutamine transesophageal echocardiography and F-18 fluorodeoxyglucose positron emission tomography were highly sensitive in predicting functional recovery of chronically kinetic or dyskinetic myocardium after successful revascularization. Thus, dobutamine transesophageal echocardiography is a clinically valuable alternative to F-18 fluorodeoxyglucose positron emission tomography for assessing residual viability and predicting functional recovery after revascularization.

Adrenergic beta-Agonists↗