PubMed Health⌕ Search

Biomedical subjects

F M Liass

Publications and source records attributed to F M Liass.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Radionuclide cisternography in the late period of penetrating cranio-cerebral wounds].

An analysis of the radiological signs is presented proceeding from the results of examination of the visualization of the CSF tract in 123 patients in whom radionuclide cisternography with 99mTc-DTPA was performed 1,3,6 and 24 h after administration of a radiopharmaceutical. The radiological appearance of pathology of the CSF system in a long-term period after penetrating craniocerebral wound was developed.

Aged↗
PubMed1983

[Oxygenation of glioblastomas and normal brain tissue during radiation therapy].

Eight patients underwent simultaneous polarographic studies of pO2 in the brain normal tissue and glial tumors under the conditions of inhaling 100% oxygen and a hypoxic gaseous mixture (10% of oxygen and 90% of nitrogen). It has been established that the inhalation of 100% oxygen causes an increase in pO2 in the brain normal tissue and tumor by 100-115%. A short-term moderate gaseous hypoxia leads to a decrease in pO2 both in the brain normal tissue and tumor by 30% on an average.

Adult↗
PubMed1983

[Proton therapy of pituitary adenomas].

The authors present the results of proton therapy in 59 patients with different hypophyseal adenomas. The period of observation lasted from 6 mos. to 5 yrs. Irradiation was done using a multifield-convergent method and a proton beam of the ITEF synchrotron. The beam energy was 200 MeV, the beam diameter 7-15mm. Radiation response and immediate results were evaluated for all the patients. The least favorable results were noted in the patients with prolactinomas, for which, in addition to irradiation, parlodel therapy is needed. No marked radiation reactions, neurological complications and manifestations of hypopituitarism were observed with the chosen doses and schemes of irradiation.

Adenoma↗
PubMed1983

[Clinical aspects, EEG and biophysical and biochemical parameters of the intracranial system in large fractionated-dose irradiation].

Seven patients operated on for intracerebral tumors received a course of large fractionating irradiation during which the patients' clinical status, changes of the ventricular CSF pressure, intracerebral pressure of the interstitial liquid, biochemical parameters of the blood and CSF and the EEG summary rate were assessed over time. The patients' reaction was characterized by a moderately expressed change of the above parameters in response to irradiation which returned to normal within 12 hrs. following large fractionating irradiation.

Biophysical Phenomena↗
PubMed1983

[Mathematical model of normal tissue involvement in gamma teletherapy].

A model of normal tissue injury as a result of exposure to ionizing radiation is based on an assumption that the degree of tissue injury is determined by the degree of destruction by certain critical cells. The dependence of the number of lethal injuries on a single dose is expressed by a trinomial - linear and quadratic parts and a constant, obtained as a result of the processing of experimental data. Quantitative correlations have been obtained for the skin and brain. They have been tested using clinical and experimental material. The results of the testing point out to the absence of time dependence on a single up to 6-week irradiation courses. Correlation with an irradiation field has been obtained for the skin. A conclusion has been made as to, first, time lag blurring time dependence within a certain range of courses, second, the presence of a component of true regeneration of which the degree depends on the volume irradiated. Proceeding from such an understanding of injury-regeneration processes a conclusion has been made that the concept of isoefficacy of irradiation courses is conditional. Volume-time fractionation is a promising direction in the development of radiation therapy.

Animals↗
PubMed1983

[Pathogenesis of late radiation necrosis of the brain].

The pathogenesis of late radiation necroses remains still unsolved in the problem of cerebral radiation injuries. The problem of primary site: vessels or medulla is a disputable one. In this case cerebral radiation nectosis developed in a 32-year-old woman 1.5 yrs. after the last course of radiotherapy for hypophyseal adenoma was over. The authors give an irradiation scheme and a detailed histological description of the foci of late radiation necrosis in the temporal lobe and in the substance of the Varolii pons which is not the zone of direct exposure. The histological picture described in the above foci is similar in many details to the process that takes place in experimental allergic encephalomyelites developing in sensitized animals. The time course of histological changes in the foci of radiation necroses shows that the process does not develop steeply but increases gradually affecting the adjoining zones of the medulla that cannot be accounted for by the direct involvement of the medullary tissue only during radiation. Thus it can be assumed that the process develops like an allergic reaction where the role of the allergen is played by the decomposition products of myelin that appear in the affected focus.

Adult↗