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Biomedical subjects

F M Pedersen

Publications and source records attributed to F M Pedersen.

26 records · Page 2Linked to original sources
PubMed1993

Endoscopic management of malignant biliary obstruction. Is stent size of 10 French gauge better than 7 French gauge?

This study reviews 139 endoscopic biliary drainage procedures in 89 patients with malignant biliary obstruction. We compared the performance of straight 7 FG (31 patients; 36 procedures) and 10 FG (45 patients; 84 procedures) stents with regard to early complication rate and late clogging. The stent patency of all single 7 FG and all single 10 FG stents were 67 days and 144 days (p = 0.11), respectively. A complication was seen in 13.9% of the procedures with a 7 FG stent and in 16.7% of the procedures with a 10 FG stent inserted. When 2 7 FG stents (13 patients; 19 procedures) were used, the figures were 110 days and 21.1%, respectively. High stenosis was more frequent in this group. We found no significant differences in the performance of a single 7 FG and a single 10 FG stent, but there was a trend towards a longer patency and a higher complication rate of a single 10 FG stent compared with a single 7 FG stent.

Aged↗
PubMed1992

[Effect of 0-(beta-hydroxyethyl)-rutoside (Venoruton) on symptomatic venous insufficiency in the lower limbs].

Forty-three patients recruited from general practice with symptom-producing chronic venous insufficiency in the lower limbs participated in a randomized double-blind clinical trial with Venoruton (300 mg x 3) or a placebo for 28 days. Twenty-eight patients were treated with Venoruton and 19 with a placebo. None of the patients received other forms of treatment for chronic venous insufficiency. No differences were observed between the two groups as regards changes in symptoms (swelling, pain, heaviness, restlessness, itching and cramps) the subjective assessment of the discomfort in the extremities or the circumference of the limbs. Venoruton does not appear to have any effect on chronic venous insufficiency in the lower limbs.

Adult↗
PubMed1991

The effect of dietary vitamin K on warfarin-induced anticoagulation.

We examined the effect of vitamin-K-rich vegetables, vitamin-K-poor vegetables and phytomenadione on the stability of warfarin-induced anticoagulation. Patients on stable anticoagulant treatment were randomized to either 1 (n = 5), 2 (n = 7) or 7 (n = 13) d with high intake of vitamin-K-rich vegetables (median daily vitamin K intake 1100 micrograms) or high intake of vitamin-K-poor vegetables (daily vitamin K intake 135 micrograms) for 6 d (n = 7), or habitual diet supplemented with 1000 micrograms of phytomenadione daily (n = 5). Nine patients (69%; 95% CI, 39-91%) who consumed vitamin-K-rich vegetables for 7 d reached activities above the therapeutic level. Two (40%; 95% CI, 5-85%) and three patients (43%; 95% CI, 10-86%) who consumed vitamin-K-rich vegetables for 1 and 2 d, respectively, exceeded the upper therapeutic limit. No changes were observed in the vitamin-K-poor group. All patients who received phytomenadione exceeded the upper therapeutic limit. Dietary vitamin K should be regarded as an important environmental factor contributing to unwanted disturbances in warfarin-induced anticoagulation.

Adult↗
PubMed1990

[Intra-atrial ECG via a central venous catheter].

The authors registered measurements of ECG via the saline column in a central venous catheter in a prospective investigation. The P-waves in the atrial ECG from various heights in the atrium and low down in the superior vena cava were compared with lead II in surface ECG and this revealed significantly larger P-waves in the invasive ECG. In patients with tachyarrhythmia, who have or require a central venous catheter, the atrial ECG will thus present an alternative to the oesophageal ECG in the diagnostic elucidation. The method is found to be easy to carry out and it is without risks or discomfort for the patient and it provides good information about atrial activity.

Catheterization, Central Venous↗
PubMed1989

Ureterorenoscopy in the management of renal and ureteric calculi.

A total of 172 ureterorenoscopies were performed in 112 patients with 131 ureteric and renal calculi. The success rates for retrieval were 65, 59 and 79% in the upper, middle and lower third of the ureter, respectively. 32% of renal calculi were removed by ureterorenoscopy. By combined endourological techniques 89% of all stones were removed. Few complications occurred, and no late sequelae were recorded. It is concluded that ureterorenoscopic stone retrieval is an efficient and safe procedure, especially for lower ureteric stones. In the hand of a trained endourologist it might be attempted for upper ureteric calculi as well, and for certain renal stones in selected patients.

Adult↗
PubMed1988

Ureteroscopic stone manipulation in the upper third of ureter and the pelvicaliceal system.

During the period of January 1984 to March 1987, a total of 15 patients with upper third ureteric calculi and 115 patients with renal calculi were treated by percutaneous nephrolithotomy (PCNL), transurethral ureteroscopy (TUU) or open surgery. In all patients, endoscopic techniques were the primary modalities of therapy. In 15 patients with upper third ureteric calculi and in 22 patients with 27 calculi in the pelvicaliceal system (five had bilateral calculi), TUU was carried out. The success rate was 67% for calculi in the upper third of ureter and 44% for calculi in the pelvicaliceal system. No persistent strictures or other serious complications were encountered. We conclude, that TUU, in experienced hands, could be considered for proximal ureteric calculi and for certain renal calculi, especially in poor risk patients and patients with only one kidney.

Endoscopy↗