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Biomedical subjects

F M Sullivan

Publications and source records attributed to F M Sullivan.

97 records · Page 6Linked to original sources
PubMed1966

Analysis of actions of 5-hydroxytryptamine in pregnancy.

1. When 5-hydroxytryptamine creatinine sulphate is injected subcutaneously in a dose of 2 mg into mice during the second half of pregnancy, the foetuses die within 1 hr. The mode of action of 5-hydroxytryptamine (5-HT) in producing this effect has been studied.2. It has been demonstrated that this is not a direct toxic effect of 5-HT. Very little passes through the placenta into the foetus, and after the injection of much larger amounts directly into the foetus no lethal effect was observed.3. It was shown that 5-HT had little effect on uterine motility in vivo, and that the much larger contractions produced by oxytocin did not produce any effect on the foetus.4. No constriction of the umbilical vessels was produced by 5-HT injected into the mother, nor did the local application of 5-HT to the cord produce any effect.5. The administration of 5-HT to the mother markedly reduced the passage of (22)Na from the maternal circulation into the placenta and foetus. This was accompanied by a reduction in the blood supply to the placenta from a normal value of 87 mul./min/g to 4 mug/min/g.6. It is suggested that the effect of 5-HT in producing foetal death is a consequence of the reduction in the transfer function of the placenta.

Animals↗
PubMedDate not supplied

Paracetamol overdose in pregnancy analysis of the outcomes of 300 cases referred to the Teratology Information Service.

A prospective study was carried out to investigate the outcome of pregnancy in 300 women who had self-administered an overdose of paracetamol, either alone, or as part of a combined preparation. Exposure occurred in all trimesters. The most striking feature of this study is that the majority of the pregnancies had normal outcomes. Over half of the mothers (160 = 53%) required treatment for the overdose, and 49 of these had specific antidotes (33 mothers had acetylcysteine and 16 mothers had methionine). The rest of the mothers were given nonspecific treatments including ipecacuanha (52), gastric lavage (42), and charcoal (16). None of the mothers died. There were 219 liveborn infants with no malformations, 61 of whom had been exposed in the first trimester. Eleven liveborn infants had malformations; none was exposed in the first trimester. On other infant exposed at 18 weeks had a diaphragmatic hernia; this pregnancy was terminated at 22 weeks. In none of these 12 infants can the malformations be directly associated with paracetamol exposure. There were no apparent differences either in the sex ratio or the body weights of term infants. There were seven full-term infants with neonatal problems that seem unrelated to paracetamol exposure. Six premature infants also had neonatal problems, which were more likely to be related to their degree of prematurity rather than paracetamol exposure. There was no obvious relationship between the time of exposure and the time of delivery. The overall conclusion is that paracetamol overdose per se is not an indication for termination of pregnancy.

Acetaminophen↗
PubMedDate not supplied

Should practice nurses be involved in diabetic care?

Primary care teams who involve practice nurses in the management of patients with diabetes mellitus provide better care. Measures of the structure and process of care are improved when nurses are involved in diabetic care.

Diabetes Mellitus↗
PubMedDate not supplied

Development of an equipment and supply list for emergency medical services delivery at an annual air show.

INTRODUCTION: Reports of medical care at mass gatherings reflect variability in mission and delivery models. Equipment recommendations are similarly varied. Thoughtful pre-planning and experience-based analysis are the best mechanisms for defining general and specific equipment recommendations. OBJECTIVE: This report presents a suggested supply and equipment list developed over a six-year period of medical coverage at an air show, with an emphasis on the usage and cost of expendable supplies. METHODS: The authors were involved in the planning for and execution of emergency medical care for a large, local, military air show on an annual basis, including provision of expendable medical supplies. A list of such supplies was developed over the initial two to three years, formalized and refined over the subsequent two years, and analyzed in the final, highest patient volume year of coverage. Detailed usage and cost was tracked over the final year for expendable supplies. RESULTS: The results of this analysis indicate that comprehensive emergency medical care from first aid to mass casualty care can be offered at reasonable equipment and supply costs, if existing equipment resources can be supplemented by expendable supplies from a pre-determined list. Given the need for large quantities of supplies for a mass casualty contingency and the low likelihood of occurrence, a loan arrangement with a supplier, with return of unused supplies, is particularly convenient and economical. The approach used in this study should be appreciable in other similar settings. In concurrent scheduled events, the iterative process described can lead to greater specificity of needs for expendable supplies.

Aviation↗