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Biomedical subjects

F M Taylor

Publications and source records attributed to F M Taylor.

At least 19 recordsLinked to original sources
PubMed1992

Adult polycystic liver disease presenting in a patient with metastatic adenocarcinoma. Cytologic and histologic findings.

The clinical, cytologic, and histologic features are presented in a case of polycystic disease of the liver. The patient was a 65-year-old female who presented with clinical and radiologic findings suggestive of metastatic adenocarcinoma to the pleural cavity and liver. Cytologic and histologic examination yielded an unsuspected diagnosis of polycystic liver disease. Metastatic adenocarcinoma to the pleura was subsequently identified on open biopsy.

Adenocarcinoma↗
PubMed1990

Nuclear pre-mRNA introns: analysis and comparison of intron sequences from Tetrahymena thermophila and other eukaryotes.

We have sequenced 14 introns from the ciliate Tetrahymena thermophila and include these in an analysis of the 27 intron sequences available from seven T. thermophila protein-encoding genes. Consensus 5' and 3' splice junctions were determined and found to resemble the junctions of other nuclear pre-mRNA introns. Unique features are noted and discussed. Overall the introns have a mean A + T content of 85% (21% higher than neighbouring exons) with smaller introns tending towards a higher A + T content. Approximately half of the introns are less than 100 bp. Introns from other organisms (approximately 30 of each) were also examined. The introns of Dictyostelium discoideum, Caenorhabditis elegans and Drosophila melanogaster, like those of T. thermophila, have a much higher mean A + T content than their neighbouring exons (greater than 20%). Introns from plants, Neurospora crassa and Schizosaccharomyces pombe also have a significantly higher A + T content (10%-20%). Since a high A + T content is required for intron splicing in plants (58), the elevated A + T content in the introns of these other organisms may also be functionally significant. The introns of yeast (Saccharomyces cerevisiae) and mammals (humans) appear to lack this trait and thus in some aspects may be atypical. The polypyrimidine tract, so distinctive of vertebrate introns, is not a trait of the introns in the non-vertebrate organisms examined in this study.

Animals↗
PubMed1988

Multiple introns in a conjugation-specific gene from Tetrahymena thermophila.

Multiple introns have been found in a gene from a ciliated protozoan. This Tetrahymena thermophila gene (cnjB) is large (7.5 kb mRNA) and active only during conjugation, the organism's sexual cycle. Six introns ranging in size from 62 bp to 676 bp were found when we sequenced a 3.1 kb segment of the cnjB gene together with its corresponding cDNA. We estimate, by extrapolation of our current data, a total of approximately 30 introns in this gene with a total gene size (introns plus exons) of 15 kb or more. The number of introns is surprising given the scarcity of introns in ciliate genes examined to date. Our findings constitute the first example of multiple introns in a ciliate gene. Having the sequence of several introns has allowed us to construct consensus sequences for T. thermophila mRNA introns. The 5' and 3' intron junctions resemble those of general nuclear mRNA (GT/AG rule is followed) but differences are seen. In particular, stretches of 10 or more adenines and thymines are found adjacent to the conserved GT and AGs at the junctions. Unusual aspects of the coding region of this gene are discussed.

Amino Acid Sequence↗
PubMed1988

Marijuana as a potential respiratory tract carcinogen: a retrospective analysis of a community hospital population.

Surgical pathology reports for the last four years were scanned for patients under the age of 40 with the diagnosis of respiratory tract carcinoma. A total of ten patients were identified and subsequently investigated for a history of marijuana use. Among these, seven revealed a history for significant exposure; five were categorized as heavy users and at least two as regular users. In view of these findings and a recent literature sampling, regular marijuana use appears to be an additional significant risk factor for the development of respiratory tract carcinoma.

Adult↗
PubMed1986

Unilateral breast enlargement due to localized fibrosis.

Unilateral breast enlargement in female adolescents is well documented, and is usually associated with fibroadenoma, cystosarcoma phyllodes, or virginal hypertrophy. We have described a rare instance of breast enlargement related to fibrosis. Whether or not this lesion is related to hormonal changes, as the other three entities are thought to be, or to trauma and associated necrosis is only speculative.

Adult↗
PubMed1979

Cardiopulmonary disease in newborns: a study in continuing medical education.

A film emphasizing the importance of tachypnea as an early manifestation of congenital heart disease was shown to physicians and nurses at 27 hospitals as part of their regular continuing medical education activities. To evaluate the effects of the program, investigators developed a pretest-posttest design which included a nonequivalent control group. Pretest and posttest data were obtained through chart audit of referrals from subjects in experimental and control groups. Dependent variables used to test the hypothesis included the age at which infants were referred and the age at which tachypnea was noted. Analysis of the data yielded significant gain scores for the experimental group, while changes in the control group were not significant. The findings indicate that a need-oriented educational program can have a measurable impact on improving the quality of patient care.

Age Factors↗