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Biomedical subjects

F M Thompson

Publications and source records attributed to F M Thompson.

At least 37 records · Page 2Linked to original sources

Pain in the posterior aspect of the ankle in dancers. Differential diagnosis and operative treatment.

A retrospective review was performed of the results of operative treatment of stenosing tenosynovitis of the flexor hallucis longus tendon or posterior impingement syndrome, or both, in thirty-seven dancers (forty-one operations). The average duration of follow-up was seven years (range, two to thirteen years). The results were assessed with use of a questionnaire for all patients, and a clinical evaluation was performed for twenty-one patients (twenty-two ankles). Twenty-six operations were performed for tendinitis and posterior impingement; nine, for isolated tendinitis; and six, for isolated posterior impingement syndrome. A medial incision was used in thirty-three procedures; a lateral incision, in six; an anterior and a medial incision, in one; and a lateral and a medial incision, in one. Thirty ankles had a good or excellent result; six, a fair result; and four, a poor result. (The result of the second procedure on an ankle that was operated on twice was not included.) The result was good or excellent for twenty-eight of the thirty-four ankles in professional dancers, compared with only two of the six ankles in amateur dancers.

Adolescent↗

The two-boned fifth toe: clinical implications.

Eighty operations on the fifth toe in 59 patients were retrospectively reviewed to determine the effect of skeletal variation on the occurrence of pathological conditions requiring surgery. The two-boned fifth toe occurred in 60% of the operated group. This is statistically significant (P < .05) as compared with 45% in our prospective control group. Our results support the theory that the stiffer two-boned fifth toe predisposes it to increased pathology, which includes hammertoes, interdigital and dorsal corns, and clawtoes.

Adult↗

Neuropeptide depletion by capsaicin does not prevent mucosal mast cell activation in the rat at weaning.

Substance P release by enteric nerves could be an initiating factor for mucosal mast cell (MMC) activation that is associated with weaning in the rat. Capsaicin, which depletes substance P from enteric nerves, should therefore prevent MMC degranulation. Rat pups received either capsaicin (50 mg/kg) or vehicle control subcutaneous injections at 3 and 6 days of life. Capsaicin-treated and control litters were killed at 16, 18, 20, 22, 24 and 26 days of life. MMC activation was measured by serum levels of rat mast cell protease II (RMCPII). Intestinal development was assessed by microdissection to measure villus area, crypt length and crypt cell production rate. RMCPII levels were similar in capsaicin-treated and control rats and peaked at day 22 of life, and intestinal development was not retarded by capsaicin treatment. We conclude that substance P release is unlikely to be an initiating factor for the MMC activation that is associated with weaning.

Animals↗

Painful os peroneum syndrome: a spectrum of conditions responsible for plantar lateral foot pain.

Plantar lateral foot pain may be caused by various entities and the painful os peroneum syndrome (a term coined by the authors) should be included in the differential diagnosis. Painful os peroneum syndrome results from a spectrum of conditions that includes one or more of the following: (1) an acute os peroneum fracture or a diastasis of a multipartite os peroneum, either of which may result in a discontinuity of the peroneus longus tendon; (2) chronic (healing or healed) os peroneum fracture or diastasis of a multipartite os peroneum with callus formation, either of which results in a stenosing peroneus longus tenosynovitis; (3) attrition or partial rupture of the peroneus longus tendon, proximal or distal to the os peroneum; (4) frank rupture of the peroneus longus tendon with discontinuity proximal or distal to the os peroneum; and/or (5) the presence of a gigantic peroneal tubercle on the lateral aspect of the calcaneus which entraps the peroneus longus tendon and/or the os peroneum during tendon excursion. Familiarity with the various clinical and radiographic findings and the spectrum of conditions represented by the painful os peroneum syndrome can prevent prolonged undiagnosed plantar lateral foot pain. Clinical diagnosis of the painful os peroneum syndrome can be facilitated by the single stance heel rise and varus inversion stress test as well as by resisted plantarflexion of the first ray, which can localize tenderness along the distal course of the peroneus longus tendon at the cuboid tunnel.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

The modified Brostrom procedure for lateral ankle instability.

Twenty-eight ankles in twenty-seven patients (average age 28) underwent the Gould modification of the Brostrom repair for symptomatic lateral ankle instability. Fifty-four percent were high level professional ballet dancers, 35% were recreational athletes, and 11% were nonathletes. Follow-up averaged 64.3 months (range 30-132 months). Of the 28 operations performed, there were 26 excellent results, one good result, and one fair result. All the professional dancers obtained excellent results. There were no failures, stretch-outs, re-dos, or complications. This operation is believed to be an excellent choice for the dancer, athlete, or nonathlete who needs a stable ankle with a full range of plantarflexion and dorsiflexion and normal peroneal function.

Adolescent↗

Occurrence of two interdigital neuromas in one foot.

In a series of 89 neurectomies, the occurrence of a second primary interdigital neuroma was less than 4%. The clinical presentation and results of surgery were similar to those of a single interdigital neuroma. Two of five patients with a suspected second neuroma in the same foot did not have this entity, but instead had had the incorrect interspace operated on by the previous surgeon. The entity of a second neuroma is truly rare, especially if careful evaluation for correct diagnosis and interspace is done.

Female↗

Flexor tendon transfer for metatarsophalangeal instability of the second toe.

Flexor to extensor transfer was used to treat painful second metatarsophalangeal joint instability in thirteen feet in eleven patients. All patients had their pain reproduced with vertical stress motion of 50% to 100% at the metatarsophalangeal joint. Seven feet had concomitant hallux valgus correction, two feet had no hallux valgus, and four feet underwent no correction for asymptomatic hallux valgus. Results at an average of 33.4 months followup showed that all patients had substantial pain relief, with eight patients becoming pain-free, and five patients experiencing mild pain. All but one were satisfied with their result. Stiffness appeared to be the source of the mild residual pain. All toes, including six toes with preoperative medial crossover toe deformity, were corrected into valgus alignment with adjacent toes. All toes operated on for the first time were able to touch the ground with grasp postoperatively. Flexor to extensor transfer is successful in reducing the second toe and relieving pain caused by instability of the second metatarsophalangeal joint, but may require rapid postoperative mobilization to ensure passive dorsiflexion equal to that of the adjacent toes to reduce postoperative uncomfortable stiffness.

Adult↗

Spontaneous atraumatic rupture of the flexor hallucis longus tendon under the sustentaculum tali: case report, review of the literature, and treatment options.

A case of spontaneous rupture of the flexor hallucis longus tendon within the hind part of the foot is reported in a middle-aged woman who had no trauma or systemic disease. Repair was effected by tenodesis to the flexor digitorum longus tendon above and below the fibro-osseous tunnel. Hyperextension of the interphalangeal joint which most troubled the patient was corrected postoperatively. Active range of motion was equal in extension. Flexion at the IP joint was present, but significantly less than the unaffected side.

Ankle Injuries↗

Participation of immune complexes in adenovirus infection.

To determine the participation of immune complexes during adenovirus infection, we evaluated serum and necropsy specimens of patients with confirmed adenovirus infection of the lower respiratory tract. In lung and kidney from seven dead patients, immunofluorescence revealed the presence of hexon, immunoglobulins and complement. These patients had clinical manifestations of kidney dysfunction. In dead patients (3/3 in whom serum was available) neither anti-adenovirus antibodies nor adenovirus-specific immune complexes could be found in the final stage of the infection. However, two of these patients had anti-adenovirus antibodies and immune complexes in samples obtained early in the infection. Most patients (16/19) who survived the infection had circulating anti-adenovirus antibodies. Half also had immune complexes specific for adenovirus in some moment of the illness. This suggests that immune complexes arise during respiratory infection by adenovirus, probably contributing to its clinical picture.

Adenovirus Infections, Human↗

Collateral ligament reconstruction of the unstable metatarsophalangeal joint: an in vitro study.

Anatomic reconstruction of the collateral ligaments of the lesser metatarsophalangeal joints is proposed for certain cases of metatarsophalangeal instability. The suggested reconstruction involves replication of the attachments of the collateral ligaments. As an example of such a reconstruction, the interosseous tendon was used in this study as a graft for anatomic replacement of the collateral ligaments. The tendon was left attached distally where its attachments include the volar plate and proximal phalanx, thereby resembling the distal attachment of the collateral ligament. The proximal portion of the tendon was inserted into the metatarsal head, replicating the attachment of the collateral ligament at that location. Preliminary testing of such a reconstruction shows that it can re-establish stability caused by loss of the collateral ligaments. Such a procedure may be applicable in select cases of crossover toe deformity and straight vertical instability.

Humans↗

Mucosal immune activation and maturation of the small intestine at weaning in the hypothymic (nude) rat.

Activation of the mucosal immune system peaks at weaning on days 21 and 22 of life in the rat. We have investigated activation in the gut associated lymphoid tissue and maturation of intestinal mucosa in hypothymic (nude) and in phenotypically normal heterozygous CBH rats at 22 days of life. Intestinal maturation, as assessed by villus area, crypt length, crypt cell production rate and disaccharidase activity, was similar in hypothymic and normal rats, and indices of mucosal immune function were elevated in both groups at this time. The proportion of mononuclear cells from the mesenteric lymph node expressing IL-2R was 11% in heterozygous and 14% in hypothymic rats as determined by flow cytometry. Immunoperoxidase staining of MLN sections confirmed the presence of IL-2R+ cells in the T-dependent interfollicular areas. However, the number of T-cells was considerably depleted in hypothymic rats. Intraepithelial lymphocyte counts and serum rat mucosal mast cell protease II concentrations were similar in the two groups, while counts of jejunal mucosal mast cells and eosinophils were paradoxically increased in hypothymic animals. As T lymphocyte function is thought to be impaired in hypothymic rats, the intact mucosal immune activity in hypothymic rats could be due to activation of intrinsic "thymic independent" T lymphocytes in hypothymic rats, or to engraftment with extrinsic maternal milk-derived lymphocytes and their activation in the infant rat gut.

Animals↗

Static quenching of tryptophan fluorescence by oxidized dithiothreitol.

The quenching of fluorescence of 5-methoxyindole, N-acetyl-L-tryptophanamide and two single tryptophan containing peptides, melittin and mastoparan X, by oxidized dithiothreitol was studied. The slopes of the Stern-Volmer plots for steady-state fluorescence quenching were 133 M-1, 71.2 M-1, 75.5 M-1 and 35.0 M-1 at 21 degrees C and pH 7.0 for 5-methyoxyindole, N-acetyl-L-tryptophanamide, melittin and mastoparan X respectively. Fluorescence lifetimes of indole or tryptophan in these compounds, as determined by multifrequency phase fluorometry, were decreased by 15% or less at concentrations that produced 50% or more quenching of steady-state fluorescence. Thus, quenching of fluorescence by oxidized dithiothreitol for these derivatives of indole appears to be largely static in nature, suggesting a ground-state interaction.

Dithiothreitol↗

Problems of the second metatarsophalangeal joint.

Diagnosis and treatment of second metatarsophalangeal joint problems are discussed. A new staging for Freiberg's disease is presented with differential treatment for each stage. Subluxation of the second metatarsophalangeal joint occurs commonly but is often unrecognized. A simple test in physical examination, the "positive Lachman" of the metatarsophalangeal joint is illustrated and explained. Although controversial, the etiology of synovitis of the second metatarsophalangeal joint is probably diverse; it can occur idiopathically or because of mechanical instabilities relating to malalignment of the first ray or disproportionate length of the second ray. When conservative treatment fails, surgical debridement of the joint is indicated. The second metatarsophalangeal is the most common chronically dislocated joint in the foot. The surgical goal is a reduced metatarsophalangeal joint and a stable toe. Surgical correction detailed by the authors involves a stepwise approach depending on the severity of the contracture, bony overlap, and deformity.

Humans↗

Rupture of the posterior tibial tendon causing flat foot. Surgical treatment.

Rupture of the posterior tibial tendon results in a progressive, painful flat-foot deformity. Other physical findings are an inability to invert the heel on tip-toe standing and loss of inversion power. In this study we report on seventeen patients with this condition who were surgically treated with a transfer of the flexor digitorum longus tendon into the navicular or an advancement of the posterior tibial tendon. Follow-up results were excellent in twelve, good in one, fair in three, and poor in one patient. Arthrodesis of the talonavicular and calcaneocuboid joints was subsequently done for the patient with the poor result.

Adult↗