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Biomedical subjects

F Madden

Publications and source records attributed to F Madden.

7 recordsLinked to original sources
PubMed1993

A comparison of doxorubicin, epirubicin and mitozantrone as single agents in advanced breast carcinoma.

Between July 1985 and December 1987, 87 patients with advanced breast carcinoma were randomized to receive single agent doxorubicin (70 mg/m2), epirubicin (70 mg/m2) or mitozantrone (14 mg/m2) at 3-weekly intervals. The patients had received no previous chemotherapy for their advanced disease but 91% had received prior hormonal therapy. The response rates were 36% with doxorubicin, 32% with epirubicin and 26% with mitozantrone, but these differences did not reach statistical significance. The median survival of all patients was 8.3 months. There was no significant difference in response rates or survival according to menopausal status. The toxicities of the three agents are compared. Nausea, vomiting and alopecia were more severe in patients treated with doxorubicin or epirubicin than those treated with mitozantrone. Myelosuppression and infective episodes occurred more frequently with mitozantrone. Two cardiac complications were reported. This study shows that the toxicity and low efficacy of all three agents limit their use as single agents in advanced breast carcinoma. The role of single agent chemotherapy and the relative toxicities of these drugs are discussed.

Adult↗
PubMed1988

Coping and the outcome of stoma surgery.

A prospective 12 month study of 106 subjects who underwent stoma surgery was conducted and has been described previously. Coping responses to the underlying diagnosis and to the stoma itself were assessed at 3 and 12 months post operatively and are related to the outcome 3 years after the operation. Difficulty coping with the stoma itself was a greater determinant of later psychiatric disturbance than difficulty in coping with the illness. Physical outcome, in those with colorectal carcinoma, was influenced by coping strategies only in the males, denial over diagnosis was significantly associated with poor outcome whereas fighting spirit over the stoma was associated with a good outcome.

Adaptation, Psychological↗
PubMed1987

Psychological effects of stomas--I. Psychosocial morbidity one year after surgery.

Sixty eight subjects who had undergone stoma surgery 12 months previously were assessed as to their psychiatric and social outcome. They had been previously also assessed at the 3rd month postoperatively. The majority had a diagnosis of bowel cancer (38) and smaller numbers had inflammatory bowel disease (15) or diverticular disease (15). 22% of the subjects had moderate or severe psychiatric symptoms and most of these had also shown similar disturbance at the 3 month assessment, indicating that the condition was longstanding. There was no significant difference in outcome between the diagnostic groups. The results also showed that ability to perform housework, leisure and sexual activities was affected in a number of subjects.

Adaptation, Psychological↗
PubMed1987

Psychological effects of stomas--II. Factors influencing outcome.

Sixteen patients with a moderate or severe anxiety and/or depression one year after stoma surgery were compared with 52 patients who had made a good psychiatric adjustment. Factors that were associated with an increased risk of psychiatric morbidity included a previous psychiatric history, postoperative physical symptoms and complications, inadequate advice and personality traits of neuroticism, anxiety and obsessionality.

Adaptation, Psychological↗
PubMed1984

Psychosocial morbidity in the first three months following stoma surgery.

One hundred and six consecutive subjects were seen in hospital a few days after undergoing surgery for bowel disease that necessitated the formation of a stoma. They consisted of patients with cancer (74), colitis (17) and diverticular disease (15). At this initial assessment details of psychological and social functioning were obtained for the preceding three months before operation. At 3 months post-operatively the subjects were interviewed in their own homes, 87 subjects were available (12 died, 7 refused) and again psychological and social assessments were made. Seventeen per cent of males and 19% of females had moderate or severe psychiatric disturbance and there was also a significant number of patients with various social disturbances. Physical diagnosis did not significantly affect psychiatric outcome. There was, however, high pre-operative psychiatric disturbance and the relevance of this in assessing post-operative symptoms is discussed.

Activities of Daily Living↗
PubMedDate not supplied

A vexing vaccination.

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Bacterial Vaccines↗