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Biomedical subjects

F Mahmood

Publications and source records attributed to F Mahmood.

45 records · Page 3Linked to original sources
PubMed1980

Anopheles culicifacies Giles: a release-recapture experiment with cohorts of known age with implications for malaria epidemiology and genetical control in Pakistan.

A mark-release-recapture experiment with the progeny of wild collected Anopheles culicifacies was performed during the monsoon season of 1978 at the village of Khano-Harni, a malarious area situated in Lahore District, Punjab Province, Pakistan. The recapture rates of males and females released at breeding and resting sites were statistically comparable and totalled 8.0% for females and 5.9% for males collected resting in houses and cattle sheds. Mating occurred mostly on the night following the evening of release when the females were about two days old. Insemination rates for females released at resting and breeding sites were statistically comparable. The initial gonotrophic cycle required four days; subsequent cycles occurred at two-day intervals with re-feeding on the same night as oviposition. Constant daily survivorship estimated from the decline in recaptures per day was 0.568 for females and 0.676 for males. Female survivorship estimated by vertical age grading methods ranged from 0.472 to 0.820. Horizontal life tables were calculated from the decline in recaptures and from vertical age-grading techniques and indicated that female or male life expectancy at emergence was less than 2.5 days. Population size was calculated using the Lincoln Index, Jackson's positive and negative methods and Itô's modification of Jackson's positive method and averaged from 1045.5 to 1049.6 females and from 449.1 to 1323.7 males. The relationship of these results to malaria transmission and genetical control is discussed.

Animals↗
PubMed1980

Antibacterial action of quinolones on Escherichia coli. I. Structure/activity relationship.

Quinolones, a large group of substituted heterocyclic compounds synthesized by ICI (U.K.), showed antibacterial activity both in vivo and in vitro studies. In the present work an attempt was made to evaluate their antibacterial activity in relation to their chemical structure. Active compounds possess carboxylic and nitroside groups. Regarding the pattern of growth inhibition quinolone with carboxylic side group showed a different behaviour than quinolone possessing nitro side group.

Escherichia coli↗
PubMed1980

Antibacterial action of quinolones on Escherichia coli. IIa. Conditions required for lethality: effect of anaerobiosis, inoculum size and media composition.

Quinolones with carboxylic or nitroside groups behaved differently in vitro under various physiological conditions tested. CarboxyQ was not active during the lag phase of E. coli and its activity was proportional to the growth rate under anaerobic conditions. NitroQ was immediately active on the cells soon after the inoculum was introduced under similar conditions. High cell density did not change the typical behaviour of these drugs. Only nitroQ was active in nitrogen-free medium while both were inactive in glucose-free medium. Chloramphenicol, reduced the activity of carboxyQ while that of nitroQ was unaffected.

Anaerobiosis↗
PubMedDate not supplied

Induced chromosomal aberrations and linkage group-chromosome correlation in Anopheles stephensi.

Genetic and cytogenetic investigations of 14 strains of Anopheles stephensi with induced chromosomal aberrations have resulted in the assignment of the three linkage groups to their respective chromosomes. In addition, the correlation between the ovarian polytene chromosomes and the mitotic chromosomes was demonstrated. Indirect evidence for the presence of heterochromatic segments in the chromosomal complement was found.

Animals↗
PubMedDate not supplied

Homozygous chromosomal aberrations in Anopheles stephensi.

Homozygotes for six autosomal paracentric inversions, an inserted paracentric inversion, an autosomal translocation, and two X-chromosome-chromosome 3 translocations in Anopheles stephensi are described. Three of these aberrations are being maintained in pure strains without the necessity of selection.

Animals↗