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F Malvezzi

Publications and source records attributed to F Malvezzi.

11 recordsLinked to original sources
PubMed1997

A 3-19-year follow-up study on diabetic retinopathy in patients diagnosed in childhood and treated with conventional therapy.

Few data are available from follow-up studies on diabetic retinopathy in patients diagnosed with insulin-dependent (Type 1) diabetes mellitus in childhood and treated with conventional therapy. We report the results of conventional insulin therapy on development of diabetic retinopathy in 100 children and adolescents (47 females and 53 males), aged 8.3 +/- 3.5 (1.2-16.4) years at diagnosis of disease. Oral or intravenous fluorescein angiography was performed during a 3-19 year follow-up in all patients. Retinopathy was staged according to the criteria of the Italian Society of Diabetology (SID). During follow-up, retinopathy was observed in 28 patients (28%). At the end of follow-up, retinopathy was present in 23 patients and had disappeared in 5. Life-table analysis showed a median disease-free interval of 10.8 years. At 10 years from diagnosis the percentage of patients free of retinopathy was 66%. Poor metabolic control, age, and degree of pubertal development at diagnosis were the most important risk factors.

Age Factors↗
PubMedDate not supplied

Severe retinopathy in systemic lupus erythematosus associated with IgG anticardiolipin antibodies.

A six-year-old boy with systemic lupus erythematosus developed insidiously a monolateral serous retinal detachment leading to severe visual loss. Serial determinations of anticardiolipin antibodies showed the presence of IgG anticardiolipin antibodies only at the time of ocular involvement. This case underlines the need for regular ophthalmologic evaluation in children with active systemic lupus erythematosus and supports the previous hypothesis of a relationship between antiphospholipid antibodies and retinal involvement in systemic lupus erythematosus.

Antibodies, Anticardiolipin↗
PubMedDate not supplied

[Acute hemolytic anemia due to autoantibodies with cholelithic complication. Echotomographic diagnostic importance in a case report].

While the cholelithiasis is very common among chronic hemolytic anemia, it is not in acute. A case of cholelithiasis as a complication of autoimmune acute hemolytic anemia in a 5 years old child is reported. A specific and accurate diagnosis was readily made with grey-scale ultrasound. Serial sonograms were obtained to follow the resolution of this case.

Acute Disease↗
PubMedDate not supplied

[Indications and results of surgical treatment in gastroesophageal reflux and hiatal hernia].

It is well known that closure of the cardia is incomplete in about 25-30% of all infants; the GER is a direct consequence. Roughly two-thirds of these infants do not show symptoms and only one-third become symptomatic. The symptoms are mild in about 75% of the symptomatic children; no treatment or medical treatment by pediatrician is required. In the remaining 25% the symptoms are moderate or severe and the clinical treatment is necessary. About the 85% of these children are cured with conservative treatment and only 15% of this small remaining group require surgery. In the paper the diagnostic problems and indications for surgery are considered. The Authors report the results of 66 children operated on for GER without (44 children) and with (22 children) hiatus hernia. The operative technique was gastropexy according to Boerema plus retroesophageal hiatopexy in the cases of important hiatus hernia. At the follow-up 61 children (92.5%) were completely asymptomatic and three showed mild symptoms without pathological radiological findings. Clinical and radiological recurrences occurred in two patients (4.5%) with severe brain damage. Two children were reoperated on postoperatively for an ileus due to adhesion. The mortality rate has been zero. In the author's opinion, the Boerema procedure is a simple, physiologic and fast technique, associated with very few complications and no mortality rate and should be considered the elective method in the surgical treatment of GER and hiatal hernia in pediatric patients.

Child, Preschool↗
PubMedDate not supplied

[Value of rectal sensitivity test in chronic childhood constipation].

The rectal sensitivity test evaluates the distension volume for which the initial transient sensation occurs on defecation (conscious rectal sensitivity threshold). The conscious rectal sensitivity threshold (S.S.R.C.) was performed on 10 normal controlled subjects and 103 children with chronic constipation, functional megarectum and normal rectoanal inhibitory reflex. Children were between 5 and 14 years old. S.S.R.C. was increased in children with chronic constipation. Encopresis was proportionally increased with relation to S.S.R.C. increase. A therapeutical protocol was applied in all patients. Fifteen patients are still being treated: 87 obtained a normal function within 8 to 23 months of treatment; in one case the treatment was unsuccessful. The period of treatment was proportional to S.S.R.C. increase. Physiopathological background of a correct management is discussed.

Adolescent↗
PubMedDate not supplied

[Long-term non-malformative urinary infections in children. (I)].

Non malformative long term urinary tract infections affect above all the female sex. The specific anatomic conditions explain only in part the predisposition for the female sex. Other determinants are the individual susceptibility and bacterial virulence. The authors studied 169 pediatric patients with recurrent urinary tract infections; of which 159 where females. The study of the blood group in 70 patients showed a net predominance of the groups B and AB. About one-third of the patients studied presented a scarce symptomatology or complete absence. The urodynamic study in 120 patients has revealed an abnormal pattern in more than 80% of the cases. According to the authors the abnormal urodynamic pattern is related to the long-term infection and is reversible in the cases which are curable. In about one-third of the cases with long-term infections which are resistent to the therapy, the cystoscopy has revealed a cystitis cystica. The study carried out by the authors permits precise indications on the specific tests that must be effectuated in this particular type of pathology and the indications of treatment.

Adolescent↗
PubMedDate not supplied

[Celiac disease and the evolution of its diagnosis. Comparison and experience at a hospital pediatric department (1975-1993). (Second part)].

In a period of over 18 years the prominent medical bibliographic marks with regard to definition, diagnosis and examinations of coeliac disease (CD) have been compared and as far as possible reproduced. The results confirm the remarks derivating from wider statistics. From the beginning of 1975 to the first six months of 1993 in Merate Hospital Pediatric Division, 323 patients were submitted to a first jejunal peroral biopsy in 133 cases (41.2%) CD was diagnosed. Since 34 children (25.6%) concluded the ESPGAN diagnostic iter with 3 consecutive biopsies, the reasons why the other patients didn't finish or respect the programs are here examined. Since 1987 a specific anti-gliadin (IgA and IgG) antibodies titrimetry has been available either in the investigation of suspect symptomatology or like control mark during the assessment or after a sure CD diagnosis. Since october 1992 antiendomysium antibodies (EMA or AEA IgA) have been determined only in selected patients. From the examination of 24 subjects now checked with AGA IgA/IgG and EMA and with a first positive biopsy, it is possible to point out that only one jejunal biopsy (or at the most a second one as a control during the gluten challenge) with the guarantee of haematologic patterns doesn't raise doubts about a CD diagnosis. Analogous considerations mainly refer to the atypical CD "late onset" when a constant lack of AGA and EMA during gluten free diet (GFD) or their changes in a non compliance or in gluten challenge, can exclude a following hystological confirmation. By this experience it follows that a specific antigliadin and antiendomysium antibodies investigation is indispensable to the shortening of diagnostic times, to the reduction of an often unwelcome invasive diagnostic method and to the discovery of the "CD iceberg".

Adolescent↗