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Biomedical subjects

F Mampaso

Publications and source records attributed to F Mampaso.

At least 91 records · Page 5Linked to original sources
PubMed1987

Hypertension in primary chronic glomerulonephritis: analysis of 288 biopsied patients.

The prevalence of hypertension in 288 patients with primary chronic glomerulonephritis was compared with that observed in a control group of 3,477 subjects from the same geographic area. 23.3% of the patients and 12.8% of the general population were hypertensive (p less than 0.01). However, if only patients with normal renal function were considered, prevalence of hypertension (12.7%) was not higher than in the control group. Hypertension was more frequent in focal segmental sclerosis (30%) and in membranous glomerulonephritis (26%) than in IgA nephropathy (9%), membranoproliferative glomerulonephritis (11%) and IgM mesangial glomerulonephritis (12%). Five years after renal biopsy, 92% of normotensive and 47% of hypertensive patients remained with normal renal function (p less than 0.001). These findings suggest that the high prevalence of hypertension in chronic glomerulonephritis is related to the declining renal function. On the other hand, hypertension appears to represent a bad prognostic sign.

Age Factors↗
PubMed1987

Effect of cyclosporin A on autoimmune tubulointerstitial nephritis in the brown Norway rat.

The effect of cyclosporin A (CyA) on the development of tubulointerstitial nephritis (TIN) in the brown Norway (BN) rat was assessed. All manifestations of TIN were prevented in rats by subcutaneously injected CyA (20 mg/kg/day). A short 7-day course of CyA beginning the day before immunization suppressed the primary and ongoing antibody response. In addition, delayed CyA treatment (starting on day 10 after immunization), when antibody response was established, drastically reduced the levels of serum anti-TBM IgG, and abrogated the interstitial inflammatory cell response, in spite of persistent kidney-bound TBM antibodies. These results indicate that CyA has a therapeutic effect on the BN rat model of TIN.

Animals↗
PubMed1987

A simple method for detecting anti-tubular membrane antibodies in rat lymphoid cell cultures.

The application of enzyme-linked immunosorbent assay (ELISA) to short cell cultures has proved to be useful in detecting immunoglobulins secreted to supernatants. This paper describes a modified ELISA to detect and quantify the production of specific anti-tubular basal membrane IgG released in vitro by lymphoid cells from Brown Norway rats with tubulointerstitial nephritis. This method uses 4-methyl-umbelliferyl-phosphate as substrate and allows to detect approximately concentrations 100 times less than the detectable concentration of visibly colored substrates. This method eliminates the need for mitogens, is precise and reproducible and the use of 4-methyl-umbelliferyl-phosphate allows a substantial increase in sensitivity.

Animals↗
PubMed1985

Clinical significance of IgM mesangial deposits in the nephrotic syndrome.

We have studied 32 patients with idiopathic nephrotic syndrome aged from 3 to 59 years. The clinical course of 20 patients with IgM mesangial deposits was compared with that of 12 patients without glomerular immune deposits. The presence of IgM deposits seems to be unrelated to any particular clinical onset, histological pattern on light microscopy, therapy response, or clinical course in our relatively short follow-up. The conclusion from this study is that IgM mesangial deposition is not a marker for response to therapy in patients with idiopathic nephrotic syndrome.

Adolescent↗
PubMed1983

Mesangial proliferative glomerulonephritis with unusual intramembranous granular dense deposits.

We have studied two patients with histories of upper respiratory tract infection. Hematuria and proteinuria were the presenting renal symptoms in one patients and an acute nephritic syndrome in the other. Serological findings disclosed depression of total hemolytic complement activity with low levels of C3 and the presence of C3Nef activity. Light microscopy showed diffuse mesangial cell proliferation. By immunofluorescence, diffuse deposits of C3 were found in the glomeruli. Ultrastructural studies revealed segmental thickening of the glomerular basement membrane due to the deposition of granular electron-dense deposits in a laminar pattern. We suggest that our cases may represent a variant of hypocomplementemic glomerulonephritis or perhaps the early stages of dense deposit disease.

Adult↗
PubMed1983

Anti-idiotype as a probe in the analysis of autoimmune tubulointerstitial nephritis in the Brown Norway rat.

Rabbit antibodies specific for the idiotype (Id) of autoantibodies to tubular basement membrane (TBM) eluted from kidneys of Brown Norway rats with tubulointerstitial nephritis (TIN) were used to analyze the immune response to TBM antigens at the humoral and cellular levels. These antibodies appeared to recognize Id determinants associated with the antigen combining site on the anti-TBM Id as well as on splenic lymphocytes. However, efforts to detect Id-positive cells in the interstitial infiltrates of kidneys with TIN failed. In contrast, in vivo injection of anti-Id serum before immunization with TBM resulted in a) significant selective suppression of antibodies to the autologous collagenase-solubilized TBM moiety but not to antigenic determinants of the intact TBM nor to those of heterologous TBM, and b) a corresponding decrease of TIN. These results suggest that anti-Id antibodies of this type can be useful as a probe for further dissecting the pathogenetic mechanisms underlying these complex autoimmune responses.

Animals↗
PubMed1981

Familial C1q deficiency in 3 siblings with glomerulonephritis and Rothmund-Thomson syndrome.

Complete absence of C1q was demonstrated in the sera of 3 siblings in association with renal and cutaneous lesions. The serologic findings were consistent with an autoimmune disorder. Hematuria was the renal symptom present in all 3 patients; proteinuria was also present in 1. Renal biopsies showed mesangial proliferative glomerulonephritis with diffuse glomerular deposits of IgM and C3 in all cases. Clinical cutaneous manifestations and the histological picture were those of the Rothmund-Thompson syndrome. Three combined diseases, characterized by renal and cutaneous affection and serologic abnormalities, are presented in this paper.

Basement Membrane↗