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Biomedical subjects

F Mandache

Publications and source records attributed to F Mandache.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Postbulbar duodenal ulcer].

In a total of 1430 patients with gastro-duodenal ulcerative disease that have been operated the authors recorded 102 cases of duodenal ulcer in the posterior area of the bulb (7%), of which 63 also had various types of complications such as: penetration (36), stenosis (14), perforation (7), hemorrhage (4), hemorrhage and perforation (2). Six differentiated surgical techniques were employed: Reichel-Polya resection and extirpation of the lesion (30), Reichel-Polya resection with extirpation of the lesion, ligature of the duodenal stump without plugging and with epiploonoplasty (34), Reichel-Polya resection with exclusion of the ulcer (35), excision-suture with gastro-entero-anastomosis (1), excesion-suture with canula draining (1), transfixiant ligatures for hemastosis (1). A total of 23 postoperative complications were recorded with 6 deaths. By making an early diagnosis and by carrying out surgery in post-bulbar ulcers with intricated attacks, resisting medical treatment, in the pre-complication stage, these conditions being possible to achieve by a narrow cooperation with internists and by an individualization of the technique, the risks and the difficulties will be reduced with regard to closure and the morbidity, as well as the lethality following surgery will be reduced.

Adult↗
PubMedDate not supplied

[Carcinoid tumors of the digestive tract].

With reference to 6 cases of carcinoid tumours of the digestive tract the authors discuss the clinical aspects, emphasizing the utility of the paraclinical tests and the benefit of an early diagnosis, in the premetastatic phase, when surgery gives the best results.

Adult↗
PubMedDate not supplied

[Experimental basis for a new surgical-therapeutic method for duodenal ulcer: gastric mucoslerosis].

On the basis of studies carried out by chronic experiments in dogs the authors noted, by clinical, chemical, radiological and histological methods, that the chemical sclerosis of the gastric mucosa performed with a sterile, fresh hypertonic solution of glucose at 60%, injected in the sub-mucosa, represents an intervention which is:--physiological, since the sclero-distrophy is achieved of the acid-secreting glands and "targeted" intra-gastric vago-sympathic denervation, while the storage function of the stomach is maintained;--feasible, since it can be easily performed from the technical view point, without hemorrhagic, perforative intra-operatory risks or hepato-renal toxicity;--fiable, since it was constantly accompanied by good clinical and functional results. The radiological examination of the barium passage in the stomach, antrum, pylorus and duodenum is normal.

Animals↗
PubMedDate not supplied

[Treatment of duodenal ulcer with chemical sclerosis of the gastric mucosa. Preliminary results].

On the basis of experimental studies and of the results obtained, the authors have applied over the last two years, sclerosis of the gastric mucosa with fresh, sterile solution of hypertonic (66%) glucose in 25 patients with duodenal ulcers and cellular and vagal hyperacidity resistant to medical therapy. Mucosclerosis was associated with gastric drainage in 14 patients with duodenal ulcer complicated by stenosis or hemmorhage. Sclerosis of the gastric mucosa is a physiological intervention because it achieves the sclero-atrophy of the acid-secreting glands and vago-sympatic denervation in the gastric territory, while the storage function of the stomach is maintained. It was not followed by extra-gastric disturbances or antro-pyloric distonia. It is easy to perform from the technical viewpoint and has a high degree of fiability, providing constantly satisfactory clinical, functional and metabolic results. Chemical values of basal secretion have decreased in a constant manner but in 9 patients the values of induced acidity showed inconstant decreases. Gastro-antro-pyloro-duodenal transit was good and all operated patients have gained weight. No diarrhea, dumping or peptic recidives were noted.

Adult↗
PubMedDate not supplied

[Acute Meckel's diverticulitis perforated by a foreign body].

The authors present the case of a patient with acute, right iliac fossa abdominal syndrome, simulating acute apendicitis. In the course of the intervention it was noted that the syndrome was determined by an acute Meckel diverticulitis, perforated by a foreign body (fish bone). In view of making the diagnosis of acute diverticulitis, that cannot be assessed before surgery, the importance is stressed of the correlation of the clinical aspects with the apendicular lesions found in the course of the operation, and, when there is no satisfactory concordance, careful checking of the cecum becomes necessary, as well as of the right annexe and of the ileon over at least three feet.

Abdomen, Acute↗
PubMedDate not supplied

[Necessary technic. Double ligation of the duodenal stump without plugging].

Gastrectomy with ulcer exclusion, associated to double ligature of the duodenal stump without infundation is a technique easy to perform in ulcers with difficult duodenum. This technique was successfully applied in 34 patients with sub-bulbar chronic duodenal ulcers (with norm- or hypoacidity), complicated by penetrating bilio-pancreatic callous lesions (one case of pancreatic fistula was recorded, that was treated with X-ray therapy). In another 10 patients with complicated ulcers (perforations - 5 cases, bleeding associated with perforation - 2 cases) the authors used the same technique. Two deaths were recorded: through generalized peritonitis in one case and through duodenal fistula, melena and peritonitis in another case.

Duodenal Ulcer↗
PubMedDate not supplied

[Surgical shock. Acute hypocatecholaminemia and therapeutic indications of an adrenocortical vasopressor sympathicolytic drug mixture. Clinical studies and experimental research].

In cases with postoperative shock and collapse a constant fall in the concentration of serum cathecholamines was noted. Thus adrenalin was reduced by 77%, noradrenalin by 86.5%, in direct proportion with the fall in the blood pressure, of the pulse amplitude and with the slowing-down (or the arrest) of the microcirculation. The reduction of serum cathecholamines also coincided with a decrease in the amount of buffer bases and of the diuresis. The adrenocortical vasopresor sympathicolithic mixture is indicated in the prolonged arterial hypotension following failure of therapy aimed at filling of the vascular bed associated with the administration of sympathicolytic drugs.

Acute Kidney Injury↗
PubMedDate not supplied

[Role of the adrenal medulla in reaction of the body to stress (clinical and laboratory studies and experimental research)].

The authors have carried out a clinical study of acute medico-surgical complications occuring in patients hospitalized following psychical stress, myocardial infarction, operatory shock and after the earthquake. In patients with duodenal ulcers and hyperacidity due to vagal neurogenic origins it was noted the presence of a sympatico-adrenergic constitutional background in 38% of the cases. By applying chemical sclerosis of the adrenals medullary the role of the medullary was demonstrated in the production of acute digestive lesions due to stress, as a result of standard electrical stimulus and of their influence on the bioelectrical reactivity of the brain, on the active learning behaviour by conditioned reaction and on the number of the circulating eosinophils following injections of A.C.T.H.

Adrenal Medulla↗
PubMedDate not supplied

Variations of catecholamines in mixed shock. Therapeutic implications. Experimental and clinical investigations.

The variations of catecholamines, cortisol and aldosterone in mixed shock (traumatic, hemorrhagic and septic) were studied experimentally and clinically. In the stage of collapse adrenaline decreased by 81.4% and noradrenaline by 62.6% as compared with the preoperative values. These decreases were found to be directly proportional to the decrease of arterial blood pressure, pulse amplitude and diuresis as well as to the slowing down or even stop of microcirculation. The value of plasma cortisol increased in the stage of collapse by 98.3% and that of aldosterone by 66.27% as compared with the preoperative values. Treatment with a pharmacodynamic sympatheticolytic-vasopressor-adrenocortical mixture is recommanded when the blood pressure remains below 50--60 mm Hg for 1--2 hrs and when the treatment for the correction of hypovolemia with fluids and sympatheticolytics has failed. Clinically, this treatment gave good results in 34 of the 58 cases studied (58.6%).

Aldosterone↗
PubMedDate not supplied

[Treatment of duodenal stress ulcer by means of chemical sclerosis of the gastric mucosa induced with a 60 percent glucose solution (results after 1--5 years)].

Sclerosing of the gastric mucosa with a 60% fresh sterile solution of glucose was applied in 60 selected patients with chronic conflictual duodenal ulcers, hyperacidic gastritis by vagal neurogenic hyper-reactivity, associated with ischaemic gastropathy developed on an sympathico-adrenergic background. The immediate operatory results were good. The late results (between 1 and 5 years) were as follows: the clinical, radiological and metabolic results were good in 57 patients. Gastric chemical analysis, the values of the hourly basal output remained high in 16,6% of the patients, and those of acidity stimulated by histamine administration remained high in 13,3% of the patients. No peptic recidive was recorded. Unsatisfactory late results were noted in 3 patients (of which forced indication of the method in one patient and non-association of drainage in two patients).

Adult↗