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F Manffrini Madrid

Publications and source records attributed to F Manffrini Madrid.

3 recordsLinked to original sources
PubMed1998

[D-dimer in different stages of pregnancy toxemia. A pilot study].

We assayed D-Dimer levels in the different stages of preeclampsia. This test appears to be the most reliable for the probability of abnormal status in patients with disseminated intravascular coagulation. Data were analyzed by dividing all cases in four groups: a.-Healthy non pregnan women (10 cases) 550 ng/ml mean levels. B.-Normal pregnant women (8 cases) 875 ng/ml mean levels. C.-Mild and severe preeclamptic patients (8 cases) 1625 ng/ml mean levels, and D.-Eclampsia and HELLP patients (6 cases) 3000 ng/ml. This results were statistical significant at level p < 0.05. It is believed that pregnancy is associated with "hypercoagulability" that it is enhance in toxemia cases. It is necessary to perform more studies with quantitative elisa techniques of D-Dimer, more cases and other markers of dic and endothelial cell injury.

Adolescent↗
PubMed1998

[Antithrombin-III in preeclampsia-eclampsia. Pilot study].

The functional levels of AT-III were determined to the following groups: A. Eleven healthy non pregnant women B. Thirteen healthy pregnant women (third trimester). C. Six preeclamptic patients. D. Five patients with eclampsia and/or HELP syndrome. The results were as follows: [table: see text] A different grade of DIC may explain the low activity of AT-III in preeclampsia and a more severe coagulation disorder in eclampsia and HELP syndrome. Our preliminary results encourage other prospective studies including larger populations to determine its usefulness as early diagnostic test and severity marker of the disease.

Adult↗