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Biomedical subjects

F Marchi

Publications and source records attributed to F Marchi.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Thyroid function in patients chronically treated with amiodarone].

The effects of Amiodarone (1000-1400 mg/week, for a period ranging from 3 to 24 months) on thyroid gland function were studied in 45 patients with heart disease, using a new method of free thyroid hormone assay. Forty-four untreated patients and 11 normal subjects were used as controls. In treated patients the prevalence of dysthyroidism was 22,2% (15,6% hypothyroidism and 6,6% hyperthyroidism); the onset of dysthyroidism ranged from 20 days to 2 years after the beginning of treatment. In control patients the prevalence of dysthyroidism was 4,4% (2,2% hypothyroidism and 2,2% hyperthyroidism). In patients with hypothyroidism (TSH greater than 7 microunits/ml) T4 levels were generally low, while T3, fT4 and fT3 levels were normal. In treated patients with hyperthyroidism (fT3 greater than 5,3 pg/ml and fT4 greater than 16 pg/ml) T4 values were high, while T3 concentrations were in the normal range. In Amiodarone-treated euthyroid patients, mean T4, fT4 and rT3 values were significantly (p less than 0,01) higher than those of control subjects; TSH levels were normal in all the groups studied. These data suggest that Amiodarone can exert both a direct effect on the thyroid gland and the peripheral metabolism of thyroid hormones. The action on the thyroid gland is suggested by the high prevalence of dysthyroidism in Amiodarone-treated patients and by the high levels of T4 and fT4 observed in patients who did not show dysthyroidism. The action on the peripheral hormonal metabolism seems to be proved by the high levels of rT3 and by the prolongation of QTc interval.

Aged↗
PubMed1980

Glycoprotein secretion in the hypothalamo-neurohypophyseal system of the rat.

Although the secretory products of the hypothalamo-neurohypophyseal system are not glycoproteins, synthesis and migration of these macromolecules occur within its secretory neurons. After being labeled with 3H-fucose in the Golgi apparatus, newly synthesized glycoproteins migrate to secretion granules, lysosomes and the plasma membrane of the secretory neurons, as demonstrated by quantitative electron-microscopic radioautography. Secretion granules bearing newly synthesized glycoproteins migrate to the pars nervosa, the labeling pattern of which was studied in rats killed from 4 h to 14 days after the isotope injection. Most of the silver grains were observed to overly the secretory axons. Labeling of pituicytes was negligible and the number of silver grains over the perivascular spaces was about 10% of the total at certain postinjection intervals. In the secretory axons, most of the silver grains over the different portions of the secretory axons changed with time. At the longer intervals, the percentage of silver grains increased over the nerve swellings (including Herring bodies) and decreased concomitantly in the undilated portions of the axons and in the nerve endings. This labeling pattern conforms with observations of the secretion products. Water deprivation increased the release of neurosecretion as well as glycoproteins from the pars nervosa. However, glycoproteins inside the Herring bodies were not easily releasible. There was a parallel decrease in the amount of secretion granules and 3H-fucose-labeled glycoproteins indicating that the glycoproteins are predominantly a constituent of the granule content. Some newly synthesized glycoproteins were probably also used in the renewal of the axonal membrane. The labeling of smooth vesicles in nerve endings was discussed. In conclusion, most of the glycoproteins synthesized in the perikarion of the hypothalmic secretory neurons migrate inside secretion graules along the axon to the pars nervosa where they are secreted.

Animals↗
PubMed1980

[Ambulatory ECG monitoring in effort angina (author's transl)].

In 20 male subjects with effort angina, an ambulatory ECG monitoring (AEM) was registered and an exercise test was carried out immediately afterwards. Usual indications for termination of test have been modified to detect the temporal relationship between the appearance of ischemic ST changes and appearance of pain. During AEM 15 patients (pts) presented ischemic episodes with a total of 80 episodes, of which 46 were asymptomatic and 34 accompanied by pain. Among the ischemic episodes registered by AEM, the mean duration of asymptomatic episodes was less that of symptomatic ones. The same can be said for the mean entity of maximum ST depression. On the basis of the temporal relationship between the appearance of ischemic ECG features and pain during exercise test, we classified 4 groups of patients: 1) pts with an almost contemporary appearance of ST alterations and pain (5 pts); 2) pts where pain appeared with a delay variable between 10 and 30 sec (6 pts); 3) pts where pain appeared with a delay of more than 30 sec (4 pts); 4) pts with absence of pain (5 pts). In these pts the exercise test was stopped either because ST depression had reached 3 mm or because ST alterations persisted for 3' without pain. Comparing the responses of the exercise test with the data of AEM, a statistical relationship was found between patients from the different groups and the prevalence of asymptomatic or symptomatic episodes of ischemia. Asymptomatic ischemic episodes during AEM are more frequent in pts who during exercise test show ischemic ECG features without pain or in pts where pain appears with a noticeable delay in comparison to ECG ischemic alterations.

Adult↗
PubMed1979

[Long-term prognosis of survivors from anterior myocardial infarction complicatedy by complete atrio-ventricular block (author's transl)].

Thirteen patients out of 42 affected by acute myocardial infarction complicated by atrio-ventricular block survived the illness and were discharged from hospital. Eight of these patients (60%) died, all in the first six months of follow up: 3 suddenly and 5 in consequence of progressive heart failure. Dead patients were all in III or IV class of the N.Y.H.A. Three had been previously submitted to permanent pacing, one of these died suddenly. Five patients survive at the end of follow up that varies from 2 to 56 months. Of these five survivors 1 patient belong to the I class of the N.Y.H.A., 1 to the II class and 3 to the III class. Among survivors there is only 1 patient with permanent pacing. This is also the only one who had syncopal attacks during a period of pacing failure. Prognosis of patients with myocardial infarction complicated by atrio-ventricular block who survive illness is dependent on functional class and seems to be not considerably modified by permanent pacing.

Aged↗
PubMed1979

Verapamil after MI.

Explore the source record for details and available documents.

Arrhythmias, Cardiac↗
PubMed1978

Radioautographic and biochemical studies of secretion of venom protein in the South American rattlesnake Crotalus durissus terrificus.

Protein secretion was investigated in the main venom gland of the South American rattlesnake, using radioautographic and biochemical techniques after a single intracardiac injection of L-(3,5-3H)tyrosine. All the snakes were injected at the fourth day of the secretory cycle and killed at 1/2, 1, 2, 4, 8 and 24 hours after injection. Most of the radioactive amino acid is cleared from the blood stream up to four hours after injection. On the other hand the specific activity (c.p.m./mg of protein) of the intracellular proteins reaches a peak at the 4-hour time interval decreasing afterwards. There was a good correlation between the values of the specific activity of the intracellular proteins and those of the silver grain density over the secretory cells at the several time intervals after the injection of 3H-tyrosine. The results of the quantitative analysis carried out in light- and electron-microscope radioautographs led to the conclusion that venom proteins are synthesized in the rough endoplasmic reticulum of the secretory cells, transferred to the Golgi apparatus from where they are carried to the secretory tobule lumen by the secretion granules. The fact that the values of the relative concentration of the radioactivity of he intracisternal granules double at the last three time intervals, strongly suggests that these structures are formed by the aggregation of the amorphous material present inside the cisternae of the rough endoplasmic reticulum.

Animals↗