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Biomedical subjects

F Marini

Publications and source records attributed to F Marini.

At least 73 records · Page 4Linked to original sources
PubMed1974

[Drug hypersensitivity].

During a drug treatment we must keep in mind the possibility of adverse effects; therefore it would be useful to look for a satisfactory test, which can be carried out safely on patients to determine their reactivity. We have found satisfactory the blastic transformation test of sensitized lymphocytes, with the pharmacological agent. The research was carried out on the blood of patients hospitalized in the Department of Infectious Diseases (Ospedale Maggiore--Verona), with skin diseases and pretreated with drugs.

Aminopyrine↗
PubMedDate not supplied

Long-term outcome of Ménière's disease: endolymphatic mastoid shunt versus natural history.

This retrospective study evaluates the outcome of 38 patients with intractable Ménière's disease with a minimum of 7 years follow-up. Twenty underwent endolymphatic-mastoid shunt (EMS) and 18 were offered surgery but declined (natural history, NH, group). At the last control, 85% of the patients who were operated on (EMS group) and 74% of the NH patients had complete or substantial control of vertigo. The difference between the two groups was not significant. However, it was significant at 2 and 4 years follow-up. At 2 years, EMS patients had complete or substantial control of vertigo in 65% of the cases, at 4 and 6 years in 85% of the cases. Only 32 % of the NH patients had complete or substantial control of vertigo at 2 years. This percentage rose to 50% at 4 years and to 74% at 6 years. Hearing results in the two groups were not significantly different. Tinnitus disappeared or decreased in 56% of the EMS patients and in 18% of the NH patients. Sixty-seven percent of the EMS patients and 29% of the NH patients reported that their aural fullness was abolished. In conclusion, over the years, approximately 8 out of 10 of our patients with Ménière's disease achieved complete or substantial control of vertigo; however, this reduction was observed earlier in EMS patients than in those who declined surgery.

Adult↗
PubMedDate not supplied

S-phase DNA damage checkpoint in budding yeast.

Eukaryotic cells must be able to coordinate DNA repair, replication and cell cycle progression in response to DNA damage. A failure to activate the checkpoints which delay the cell cycle in response to internal and external cues and to repair the DNA lesions results in an increase in genetic instability and cancer predisposition. The use of the yeast Saccharomyces cerevisiae has been invaluable in isolating many of the genes required for the DNA damage response, although the molecular mechanisms which couple this regulatory pathway to different DNA transactions are still largely unknown. In analogy with prokaryotes, we propose that DNA strand breaks, caused by genotoxic agents or by replication-related lesions, trigger a replication coupled repair mechanism, dependent upon recombination, which is induced by the checkpoint acting during S-phase.

DNA Damage↗
PubMedDate not supplied

[Biomechanical and clinical interpretation of firearm wounds. General problems. V. The propaedeutic ABC of terminal ballistics].

Modern portable firearms, whether for military or civilian use, present substantially different features as instruments for striking, wounding and killing compared to those used in the past on account both of their intrinsic characteristics as thermo-chemico-ballistic machines, guaranteeing extra, more easily achievable performance and of the characteristics of the bullets used. The factors responsible for this difference, which consists essentially in an unprecedented wounding capability, are, in the military field, the enormous amount of research which only now is beginning to yield a bare minimum of concrete results in terms of futuristic forms and devastating performance, amongst other things because it is easier to achieve, and, in the "civilian" field, the maniacal search for an unlikely definitive wound, based on the unusual nature of the cartridge and on sophisticated training.

Biomechanical Phenomena↗
PubMedDate not supplied

Percutaneous endoureterotomy of uretero-ileal stenosis in the Camey-Le Duc substitution bladder. Our experience in two cases.

Two patients with a Camey-Le Duc substitution bladder who presented monolateral uretero-ileal stenosis were treated by percutaneous endoureteral incision using electrocautery and moulding stents. The results were encouraging in one patient after 12 months follow-up. In the other case, however, endourological manipulation had solely symptomatic purpose since the stenosis was caused by local recurrence of primitive neoplasm.

Carcinoma, Transitional Cell↗
PubMedDate not supplied

[The clinical biomechanical interpretation of gunshot wounds. The general problems (IV). The propedeutic ABCs of the terminal ballistics].

If we want to enunciate the damaging potential of a bullet fired from a gun we have to express ourselves right from the outset in terms of destructive work, that is to say not only destruction of the structures the bullet passes through, but also, above all, destruction of the homeostatic condition. In modern terms, this is particularly true of the abdomen, which, in perspective, above and beyond any direct involvement, is a candidate for an interesting role. As regards the translation of this destructive force in mathematical language, formulae are proposed in kilogram-meters, feet per second and Joules. A basic factor in external ballistics, quite apart from the actual forces involved, is the trajectory in space, the hyperbola, though we should also reflect on the problem of resistance, which has such a considerable effect on the behaviour of the "ideal" bullet in the atmosphere (the smallest calibre for a given mass, with the attempt to rid itself of its forced subordination to the calibre of the barrel). This leads us on to the subsequent concept of the "ballistic coefficient" and, in itself definitively established the basic assumptions of terminal ballistics.

Abdominal Injuries↗
PubMedDate not supplied

Experience with our first 400 treatments with ESWL and URS.

From September 1988 to April 1989, 400 patients with stones in the calix (40%), in the renal pelvis (45%), in the ureter (15%) and with staghorn calculi (5%), underwent shock wave treatment. In the majority of patients therapy was carried out with general anesthesia. Disintegration was achieved in 95% of stones in the kidney and 44% of stones localized in the ureter following in situ ESWL. The ureteronephroscopy and stone push-up with replacement into the renal pelvis was performed in 56% of ureteral calculi. The average number of impulses to achieve disintegration was 1,850. In 20 patients 4,000 shock waves were necessary. We studied these patients with echotomography, CT scan and magnetic resonance imaging 48 hours after the treatment. The aim of this trial was to assess the efficacy and cost benefit ratio of the Tripter X1 lithotripter.

Endoscopy↗
PubMedDate not supplied

Combined therapy of staghorn calculi with ureteronephroscopy (URS) and extracorporeal shock wave lithotripsy (ESWL).

We report our experience with 25 cases of staghorn calculi treated by combined ureteronephroscopy and extracorporeal shock wave lithotripsy. The equipment used and the ultrasonic disintegration techniques are described. We believe that the procedure, followed by ESWL, may constitute, in selected cases, an alternative to conventional combination therapy.

Adult↗
PubMedDate not supplied

[Reinterpretation of the hepatic abscess, a new dimension in abdominal digestive surgery].

Pyogenic abscess of the liver is viewed here as a surgical disease, which appears to raise doubts as to its actual identity. Though located in a given abdominal organ, such abscesses find it hard to recognize this as their exclusive setting and attempt to shrug off these traditional confines. They aspire, rightly or wrongly perhaps, to symbolize a splanchnic context, though, in actual fact, the latter--at least for contingent, doctrinal reasons--is confined to the bipolar liver-bowel system. This context presents its candidacy as playing a leading role in a disease of such importance as to be regarded almost as the "Caudine Forks" of the very process of "surgical" dying. Liver abscess and multiorganic or multisystemic organ failure (MOF or MSOF) might thus be viewed as the two opposite poles (taxonomically definable) of a single clinical condition, which fans out over a broad area and for the most part is only barely known to us. Though is characterized by its abdominal location, it would be all too simple to define the condition as abdominal. In this case, in fact, the abdomen speaks an unusual language, not the habitual, traditional, "spatial" language of location, but the as yet uncertainly articulated "biological" or, why not, even "biosurgical" language of mediation. Is this then a turning point in the pathological field? No, if by that we mean a new concept of the problem. In effect, the concept dates back several centuries and, moreover, darries a heavy burden of responsibility, such as, for instance, having induced the Nobel Prize-winner Elie Metcknicoff (Metcknicoff E., The prolongation of life. London, Heinemann, 1907) to come up with theories appropriated and implemented surgically by Sir William Arbutnot Lane, gaining him nothing but sad notoriety (Gordon R., Great Medical Disasters, Hutchinson, London-Melbourne, 1983). "Concept" is a euphenism, and a more appropriate term might be simply "intuition". The real innovation lies in reviving this old intuition, reinterpreting it now, in fact, as a "concept". The code for this modern interpretation has barely been sketched out in its essentials, but is daily going from strength to strength.(ABSTRACT TRUNCATED AT 400 WORDS)

Endotoxins↗
PubMedDate not supplied

Quality of life in patients with advanced bladder cancer treated by tumorectomy and systemic adjuvant polychemotherapy (M-VAC). Our experience in 14 cases.

Fourteen patients with advanced bladder cancer T3 to T4, N1 to N2 positive, were treated with reductive surgery (tumorectomy) and systemic adjuvant polychemotherapy (M-VAC: methotrexate 30 mg/m2, vinblastine 3 mg/m2, adriamycin 30 mg/m2 and cis-platin 70 mg/m2) in the period from December 1985 to December 1987. The aim of this combination was to preserve detrusor function in order to give tha patients a better "quality of life". After a follow-up varying from 12-24 months, complete clinical remission for 18 months was observed in 2 patients, the remainder showed an improvement of the performance status compared with those treated by conventional therapy (radical cystectomy and/or radiotherapy) but no changes in overall survival was achieved.

Aged↗