Absorbable sutures are initially equal or superior to nonabsorbable sutures in terms of tensile strength but are absorbed at variable rates by the action of hydrolysis. This study demonstrated that the in-vivo half-life tensile strength of the braided absorbable sutures polyglycolic acid (Dexon Plus) and polyglactin 910 (Vicryl) is 2 weeks, whereas those of the monofilament absorbable sutures polyglyconate (Maxon) and polydioxanone (PDS) are 3 and 6 weeks respectively. The addition of a single hitch or six knots reduced the in-vitro tensile strength by 30% to 35%. Polyglyconate (Maxon) suture demonstrated the best in-vitro knot security.

Animals↗

PubMed1987

Dynamics of the optical Freedericksz transition.

Explore the source record for details and available documents.

Journal Article↗

PubMed1987

Limitation of deuterium labelled methoximes as internal standards in the mass spectral analysis of prostaglandins.

A reported method for the preparation of d3-methoxime derivatives as internal standards for prostaglandin assays by gas chromatography-mass spectrometry was evaluated. Sample derivatization resulted in 1.5-86% exchange of the d3-methoxime in a series of prostaglandins. Exchange was minimal when the methoxime was on the 5-membered ring; whereas, acyclic methoximes exhibited extensive exchange. Induced strain energy due to the steric interaction of the hydroxyl group and the C13-C20 alkyl side chain with the gem-dimethoxylamine transition state is offered as an explanation for the unusual stability of PGE2. The use of 18O exchange of the carboxylic acid function is presented as an alternative for the preparation of unavailable labelled eicosanoids.

Deuterium↗

PubMed1984

The 5-hydroxytryptamine-releasing properties of two epimer quinoline derivatives.

Two epimer quinoline derivatives, PK 5078 and PK 7059, have been shown to be potent at releasing 5-HT from blood platelets. Moreover PK 5078 was also a potent and selective inhibitor of the uptake of 5-HT, being about 20 times as active as clomipramine. Both drugs, like p-chloroamphetamine, released 5-HT but did not inhibit MAO-A. Whilst p-chloroamphetamine seemed to be active on the cytoplasmic pool of 5-HT and reserpine on the vesicular pool, PK 5078 and PK 7059 were effective first on the vesicular pool and then on the cytoplasmic pool. The quinoline derivatives were devoid of the typical side-effects of amphetamine-like drugs, i.e. hyperactivity, anorexia and group toxicity. For these reasons PK 5078 and PK 7059 can be considered to be a new type of selective 5.HT-releasing drug.

Animals↗

PubMed1983

A subacute treatment of L-methionine induces an increase in the number of [3H]spiperone binding sites in the striatum of the rat.

A subacute treatment, 500 mg/kg I.P. twice daily during 5 days, by L-methionine provoked an increase in the Bmax of [3H]-spiperone binding in the striatum of the rat. This increase was associated to a decrease in membrane microviscosity. However in these conditions no changes were found in the [3H]-DHA, [3H]QNB bindings or in the brain dopamine sensitive adenylate cyclase activity. L-methionine treatment reduced the accumulation of Dopa after NSD 1015 and antagonized the decrease in striatal acetylcholine provoked by haloperidol. Thus L-methionine might be a new potential drug for Parkinson's disease treatment.

Animals↗

PubMedDate not supplied

Subtalar arthrodesis in children.

We present a clinical and radiological retrospective study of 30 patients (51 feet) with valgus deformity of the feet who had three different types of subtalar extraarticular and intraarticular arthrodesis. Children with cerebral palsy, myelomeningocele, and agenesis of the corpus callosum associated with progressive polyneuropathy were studied. The results were considered excellent and satisfactory in 73% of the feet. The combined Grice-Green-Batchelor procedure gave the best results, with 84% excellent and satisfactory results, with bony union in 96% of the feet. Weight-bearing films of the ankles in the anteroposterior plane are essential to determine the true extent of the deformity before operation.

Agenesis of Corpus Callosum↗

PubMedDate not supplied

[Alzheimer's disease: language and dementia: importance of upkeep of communication].

Explore the source record for details and available documents.

Aged↗

PubMedDate not supplied

[Hospitalization of adolescents in a regional hospital center].

A one-year study of hospitalizations of 12-18 year old adolescents in a general hospital in the East of France showed a rate of hospitalization of 4.3%, lower by 1/2 than that of the general population. More than half of the patients were admitted to surgical wards, one third to wards of internal medicine and, for the girls, 15% to wards of gynecology and obstetrics. One third of the adolescents were admitted to departments of pediatrics. The causes of admission were, in order of frequency, accidents, infections and mental disorders. On the basis of these data, the modalities for reception of adolescents in hospitals are discussed.

Adolescent↗