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Biomedical subjects

F Marzotko

Publications and source records attributed to F Marzotko.

At least 19 recordsLinked to original sources
PubMed1985

[Special forms of ectopic pregnancy].

The symptomatology of acute intraabdominal and extrauterine bleeding presents a multiform picture. In the field of gynecology and obstetrics several other diseases are also observed besides the forms of ectopic pregnancies. - Among 554 ectopic pregnancies treated at our Department of Gynecology and Obstetrics between 1962 and 1981 we found 11 rare cases of these pregnancies: 2 cervical, 2 bilateral tubar, 5 primary intrafollicular ovarian, 1 primary, and 1 secondary abdominal pregnancy. These forms have been discussed and compared with international literature with regard to frequency, etiology, diagnostics, differential diagnostics, clinical course, therapy, and lethality.

Cervix Uteri↗
PubMed1985

[Prognostic significance of lymph node metastases in operable cervix cancer of categories T1 and T2].

In a retrospective long term study the tumorbiological importance of metastases in lymph-nodes of cervix cancer have been examined. The base of this presentation consists of a follow up study of 855 patients suffering from cervix cancer (stage I 557 pat., stage II 298 pat.) in relation to lymph-node-metastases. Metastases in 9,9% in stage I and in 18,4% in stage II could been proved histologically. The 5-year-survival-rate decreased in stage Ib from 89 (T1 No Mo) to 59% (T1 Ni Mo) and in stage II respectively (T2a No Mo) from 73 to 27% (T2a Ni Mo) and from 89 (T2b Ni Mo) to 52% (T2b Ni Mo). About 59% of relapses appeared in the treated region of the pelvis. In cases of adenomatous and dedifferentiated cancer 4% more regional metastases could be found than in squamous cell cancers. By means of post-operative irradiation (especially telecobalt-therapy) the relapse-free interval could be prolonged about one to two years. Recently tumourbiological knowledge is involved in the discussion. The appearance of lymph-node metastases represents the worst prognostic feature for the cure and the life of the patient suffering from cervical cancer.

Adenocarcinoma↗
PubMed1984

[Cathepsin D activity in human ovarian carcinoma].

In the tissue of 54 ovarian carcinomas and 38 normal human ovaries the activity of cathepsin D was determined by means of the Anson-method. In ovarian carcinomas the mean activity of cathepsin D was 4515 pmol T/s/g tissue, in normal ovarian tissue only 2119 pmol T/s/g. The difference is significant (p less than 0,001). The dependency on age of the activity of cathepsin D suitable for normal ovary, got lost in cancer tissue. There is no relationship between the amount of activity of cathepsin D and the stage of the tumour. Extreme high activities of cathepsin D were found in metastatic ovarian carcinomas. The activity of cathepsin D is higher in endometrioid and papillary than in mucigenous and hypernephroid ovarian carcinomas. The different activities of cathepsin D were discussed with regard to the invasive growth of cancer and to deranged protein metabolism.

Adult↗
PubMed1984

[Carcinoid tumors of the appendix and small intestine as unusual secondary findings during gynecologic operations in and outside of pregnancy].

Report is given on 9 patients suffering from a carcinoid observed at the Department of Gynecology of the Medical Academy of Erfurt from 1963 till 1982: one carcinoid of the small intestine with metastases and abdominal syndrome and eight cases with carcinoid of appendix. Two of these during pregnancy and the carcinoid of small intestine show the difficulties of the differential diagnosis and the possible combinations in face of gynecologic diseases. In 2 cases of carcinoid of the appendix during pregnancy the children didn't show any malformations. On the strength of supervision of the course we think in accordance to the international literature the sole appendectomy will be sufficient. Nevertheless we make demands for a careful investigation and palpation of the appendix in all gynecologic operations and if necessary the appendectomy.

Adolescent↗
PubMed1983

[Comparison between colposcopic and cytologic findings in relation to clinical and histologic diagnoses in carcinoma in situ].

From 1977 to 1979 95 cases of carcinoma in situ had been detected at the Gynaecological Department of the Medical Academy of Erfurt. In 81 of these women there was a cytological examination before treatment. The accuracy of cytology and colposcopy was opposed the histological diagnosis in these selected cases. An agreement of colposcopy, cytology and histological findings could be found in 70 cases. In 6 cases colposcopy and in 4 cases cytology was wrong. Only in one case both examination methods failed.

Carcinoma in Situ↗
PubMed1983

[Cervix carcinoma in pregnancy].

42 cases with the combination of cervical carcinoma and pregnancy are reported which are observed at the Department of Gynaecology of the Medical Academy of Erfurt from 1951 to 1981. Reference is made to the possibility of an early diagnosis by means of an exactly organized prenatal care. The exactly performed postoperative classification of all these cases refers to the very difficult judgement of the pre-operative staging. A 5-year survival rate of 69% could be achieved by Wertheim's hysterectomy and individualized post-operative radiation, in comparison with international literature a satisfactory result. A better prognosis of this cancer during pregnancy may be supposed.

Adult↗
PubMed1981

[Problems of urogenital abnormalities--uterus bicornis and bicollis, right double ureter with hydroureter, urogenital cyst formation].

Reported in this paper is a rare urogenital malformation in a patient, 17 years of age. Extensive presurgical diagnosis of cele and cysts formation in the minor pelvis, with the right parts of vagina and ureter of a doubled urine-excreting system being involved, was confirmed by surgical therapy in two sessions. This hydronephrotic ureter, with its normal ostium located in the urinary bladder, was found to communicate with the right cervix of a double-bicorn uterus. Excess pressure in the cavities caused fluid to empty splashingly from the right vagina into the left which was in normal condition. The effects of such combination of malformations on individual life are discussed.

Adolescent↗
PubMed1981

[Accuracy and general relevance of preoperative lymphography in gynaecology (author's transl)].

Lymphographic findings obtained from 304 patients were compared with results obtained from histological testing of extirpated lymph nodes, with the view to making an assessment of accuracy of presurgical lymphography. Agreement was recordable in 82.3 per cent of all cases, while 3.3 per cent of the findings were falsely negative and 4.9 per cent falsely positive. The relevance of preoperative lymphography to diagnosis and planning of therapy for various gynaecological carcinomas is discussed.

Diagnostic Errors↗
PubMed1981

[New technique for use of low temperatures in uterine cavity (author's transl)].

Cases of repetitive or extremely secondary anaemia in the wake of therapy-resistant genital bleeding so far had been tackled by radium treatment, which led to radiological castration. Such approach was based on hysterosalpingography and established absence of malignancy, and it used to be applied also to younger patients with reduced or lost operability. The author have devised and tested a simple cryo-intrauterine applicator by which lasting or strong recurrent uterine bleeding can be readily controlled. Complete removal of the endometrium is now possible without any impairment of ovarian function. Foundations and methods are described in detail, with clinical conclusions being drawn.

Adult↗
PubMed1979

[Effectiveness of adjuvant chemotherapy in ovarian carcinoma].

A report is given about the efficiency of the so called adjuvant chemotherapy in 26 cases (26 patients suffering from ovarian cancer in the stage T1M0N0) in a time of 10 years (1968-1977).--After the primary operation-therapy, a part of the patients (9) got the cytostatic drugs Trenimon or Cyclophosphamid. The patients of the control group got nothing. The survival times of both groups showed no significant distinctions. -- The results show that the adjuvant chemotherapy in cases of ovarian cancers in stage T1M0N0 can not be recommended because there are too many side effects of the these cytostatic drugs.

Adult↗
PubMed1977

[Contribution to carcinosarcoma of the uterus (author's transl)].

The histogenesis of carcinosarcomas of the uterus is not clear yet. The different histologic structures of a collisions-tumor which is characterized by a secondary intermingling of sarcomatous and carcinomatous elements are described, and their etiolgy and pathogenesis are discussed.

Aged↗
PubMed1976

[In vitro testing and clinical experience with 5-fluorouracil in gynaecologic cancer (author's transl)].

201 pretherapeutic tests for sensitivity of gynaecologic cancers against 5-fluorouracil were performed. Only 8.5% of cases proved to be sensitive in tissue culture. Clinical results with 5-FU monotherapy were unsatisfactory. 5-FU should only be used very critically in gynaecologic neoplasims. The value of predictive tests for sensitivity against cytostatics in planning individualized selective chemotherapy is emphasized.

Adult↗
PubMed1975

[Cell-culture-tests (oncobiograms) in 105 bronchial carcinomas (author's transl)].

Thirty-six oncobiograms (cell culture tests) of bronchial carcinomas are reported. One hundred forty-eight single tests showed a predominant cytostatic sensibility of the different squamous cell carcinomas and alluded to a special effectiveness of the alkylating chemotherapeutical agents, so that the oncobiogram may be able at the same time to support the polychemotherapy to day discussed and realized in all special branches.

Adenocarcinoma↗