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Biomedical subjects

F Mattioli

Publications and source records attributed to F Mattioli.

At least 73 records · Page 4Linked to original sources
PubMed1981

[Effects of extramucosal duodenal myotomy in dogs (author's transl)].

Numerous experimental and clinical observations have established the role of hypertonic duodenal dyskinesia in the etiology of duodenogastric reflux and delayed emptying of the stomach. The original procedure proposed, section of the duodenal muscle fibres, demonstrated a relative hypotonia of the viscera and maintenance of antropyloroduodenal coordination. The present study confirms the effects of extramucosal duodenal myotomy after short- and long-term follow-up in dogs: reduction in gastric emptying time, absence of duodenal stagnation, and lack of morphological changes in the viscera. Unfavorable in duodenogastric reflux, it has favorable effects, on the contrary, on gastric emptying and antral function.

Animals↗
PubMed1981

Modifications in gastroduodenal motility induced by the extramucosal section of circular duodenal musculature in dogs.

The effect induced on the gastroduodenal motility by the extramucosal section of the circular layer of the first two parts of the duodenum, excluding the pylorus, was studied in a series of 5 dogs. The myoelectric and manometric activities of the antrum, pylorus, and duodenum were recorded by using special devices surgically implanted in the gut wall. The recordings were made 3 mo after operation, both during basal conditions and after stimulation with neostigmine. The results were statistically compared with those obtained in a control group of 4 dogs in which the electromanometric devices had been implanted 3 mo before. The gastric emptying time of a food-barium meal was determined radiologically before the operations, and 3 and 9 mo after. The results demonstrate that extramucosal duodenal myotomy: (a) significantly decreases the basal and stimulated motor activity of the duodenum, without noteworthy alterations of the gastroduodenal myoelectrical activity and coordination of motor waves; and (b) significantly shortens the gastric emptying time.

Action Potentials↗
PubMed1979

Prolonged manometric study of the gastroduodenal junction in man.

A study of the motor activity of the gastroduodenal (GD) junction has been carried out on 8 subjects by using an original probe provided with a suction cup, that allows not only a duodenogastric (DG) pull-though, but also a prolonged recording of the pyloric, antral and duodenal motor activity, in basal condition and after intraduodenal instillation of HCl 0.1 N and intravenous infusion of cerulein. The position of the probe was controlled with fluoroscopy and transmural potential difference. The DG pull-through did not show a zone of high pressure at the GD junction, but the prolonged study showed, during HC1 and cerulein administrations, a significant increase of the pyloric tonus.

Adult↗
PubMed1979

Action of levamisole on E-rosette forming cells and serum adenosine deaminase in Hodgkin's disease.

The interaction of levamisole and/or adenosine in vitro on E-rosette forming cells (RFC) of healthy subjects and on low RFC of patients affected with various diseases was investigated. Levamisole did not enhance normal RFC. The drug enhanced low RFC in some patients (responders) but not in others (non-responders). Adenosine inhibited normal and low RFC and this inhibition could be reversed by levamisole. Further, levamisole 150 mg 2 days a week was given to 12 Hodgkin's disease (HD) responders for 2 weeks, then 150 mg 1 day weekly for 2 1/2 months. After one week of treatment RFC increased and the enhancement could be maintained during the whole treatment period. Lastly levamisole in vitro and in vivo diminished serum adenosine deaminase activity in normal subjects and HD patients.

Adenosine↗
PubMed1979

Pyloric reflux: a duodenal functional problem?

A manometric study of duodenal motor activity was performed in 8 duodeno-gastric (D.G.) reflux patients and in 5 healthy volunteers. The examination was done by an open-tip probe containing three catheters which was positioned in the descending portion of the duodenum. The evaluation of manometric data evidenced in D.G. reflux patients a Motility Index (M.I.) significantly higher than that of control subjects in all the three duodenal recording points both in basal conditions and after prostigmine stimulation. Evaluation of the percentage of coordinated waves showed that in D.G. reflex patients the waves had a frequency lower than that in normals. On the basis of these results we can conclude that the duodenum of patients with D.G. reflux exhibits hyperkinetic-dyskinetic disturbances suggesting an important role of the duodenum in determing D.G. reflux.

Adult↗
PubMed1977

Inhibition by cinnarizine of the properdin-dependent activation of complement.

Cinnarizine (1-benzhydryl-4-cinnamylpiperazine dihydrochloride), a well-known antagonist of vasoactive agents, has previously been shown to inhibit the activation of complement at the level of the fourth component. Cinnarizine was now tested in a system of complement activation by the properdin-dependent alternative pathway. At the concentration of 7.10(-5) M the compound completely inhibited the hemolytic reaction, which is the consequence of human complement activation in the presence of inulin or zymosan. This in vitro effect of cinnarizine was abolished by the addition of 1 mM MgCl2. These findings extend the anticomplementary activity of cinnarizine to the properdin pathway and support its interaction with the magnesium-dependent steps of the activation sequence.

Animals↗