Biomedical subjects
Publications and source records attributed to F Matzkies.
In 8 subjects, the oral protein supply is modified in periods of 3 days each. With increasing protein intake, a decrease of the serum uric acid levels results as well as a significant increase in uric acid excretion and uric acid clearance. On the basis of the data obtained, it may be assumed that protein has a uricosuric action.
The uric-acid lowering effect was investigated in a group of 2220 patients. 1984 of these were employed for statistical evaluation purposes. On average, the uric acid level was reduced from 8,24 +/- 1,16 mg/100 ml to 5,32 +/- 1,265 mg/100 ml. In 82 % of all the cases, the uric acid level at the end of the treatment period was below 6,4 mg%, both in patients treated throughout with 50 mg benzbromarone (NarcaricinRmite) and in those changed over to 100 mg benzbromarone (NarcaricinR) after 1 to 3 weeks. The lowering of the uric acid levels was in no way related to hypertension, adiposity, hyperlipoproteinaemia, diabetes mellitus or age.
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Elemental diets are in use for therapy of intestinal fistulas, diarrhoe of unknown etiology, short-bowel-syndrom and chronic inflammatory bowel diseases.
16 adults received Benzbromarone at a dosis from 50 mg to 100 mg/day. No alteration of sodium and potassium concentration in serum could be found. During Benzbromarone application the elimination of sodium, potassium and water was not influenced.
23 patients with different forms of hyperlipidemias received procetofen (3 X 100 mg/day) over a period of fourteen days. The cholesterol concentration in blood showed a significant reduction from 322 +/- 30 mg/dl to 227 +/- 37 mg/dl, triglycerides dropped from 221 +/- 84 mg/dl to 129 +/- 34 mg/dl and uric acid diminished from 6,1 +/- 1,4 mg/dl to 4,6 +/- 0,8 mg/dl.
In a collective of 3899 out-patients, the effect of uric acid reduction of benzbromarone was tested. Ten days after beginning of treatment, a uric acid concentration of 5.1 to 5.7 mg/100 ml had been obtained. Three months after beginning of therapy, uric acid values were at 4.9 mg/100 ml, independently of age and sex. As side-effects were observed:diarrhoea in 1% (n = 41) of the treated patients, furthermore, 0,8% (n = 31) complained of gastro-intestinal trouble such as pressure over the stomach, nausea, sensation of fullness and epigastric pain. Only in 2 of the 3899 patients (0.05%) the appearance of a renal colic was observed.
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Over a period of 12 hours a total amount of 190 g fructose, 190 g glucose, 145 g xylitol, 96 g fat and 99 g amino acids were infused. The utilization of carbohydrate was not diminished despite the high fat load. In addition, the antiketogenic action of carbohydrate was still provable. The nitrogen balance was positive as an indicator of good utilization of amino acids. Therefore, simultaneous administration of a carbohydrate mixture and a fat emulsion as energy sources during application of amino acids is recommended.
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In a carbohydrate combination solution containing 12.5 mEq/1 calcium and 12 mmol/1 phosphate the concentrations of calcium and phosphate were kept constant during parenteral infusion therapy with carbohydrate, at a rate of 0.5 g/kg/h and amino acids at a rate of 0.1 g/kg/h. Balance for calcium and phosphate was positive. Calcium excretion was slightly above the levels determined in oral nutrition. A slight modification of calcium supplement by changing the concentration of the solution to 10 mEq/1 is suggested.
The water balance and the electrolyte balance were measured in 6 patients after 14 days of total starvation. After fasting a 600 calorie formula diet was given for the whole period. The potassium balance was +32 mval/day and that of sodium +120 mval/day. The total loss of potassium in 14 days was 488 mval and that of sodium only 126 mval. Sodium loss is replaced within one day of refeeding. No replacement of the potassium loss was noticed during the 4 day treatment.
Some therapeutic measures cause hyperuricemia, which may require treatment in certain cases. The following may induce hyperuricemia: cytostatic long-term treatment, weight reduction through fasting, antihypertensive treatment with different chlorothiazides but also furosemide and etacrynic acid, anti-tuberculostatic therapy and Parkinson long-term treatment.