There are only a few studies which could support conclusions concerning the strength of the muscles surrounding the hip joint and especially concerning the strength relationships following implantation of endoprotheses. The aim of this study was to examine the pre- and postoperative course of strength deficits in this musculature compared to clinical parameters and the uninvolved side. Fifty-eight patients between 30 and 67 years of age, in whom individual total hip protheses were implanted were clinically examined prior, 9 weeks and 6 months after surgery. Moreover, the maximum isometric strength of abductors, flexors, and rotator muscles as well as maximum isokinetic strength of the extensors and flexor musculature at 60% and 120%/s were measured. The flexor and extensor musculature already showed a clear increase in maximum strength after 9 weeks and 6 months (90-124%). By contrast, the isometric strengths of the rotators increased only slightly, the abductor strength decreased after 6 weeks to below the preoperative baseline level and attained this level again only after 6 months. The clinical parameters Trendelenburg sign, limping and walking capacity were clearly improved after 6 months, but no correlation to the abductor strength could be demonstrated. It is concluded that limp-free gait can be attained even without maximum strength increase in the abductors, which are important for fluid gait, at least for short distances. The importance of regular training of the rotator and abductor musculature in coxarthrosis is emphasized to delay limitation of movement and decreased strength in the sense of capsule pattern.

Adult↗

PubMedDate not supplied

Interaction and compartmentalization of the components of bacterial enzyme systems involved in cell energetics.

Bacterial enzyme systems, especially those which are involved in cell energetics, often show a common characteristic feature: their constituents (either interacting enzymes or subunits of a given enzyme complex) are physically separated. They are located in different functional entities, such as cytoplasm or periplasmic space. This kind of cellular and macromolecular organization enables the cell to establish spatially separated but neighbouring zones in which distinct conditions are created or maintained. This intrinsic imbalance is one of the keys for the process of life. As the mediator between the two compartments, the cytoplasm and the periplasmic space, the cytoplasmic membrane--itself a functional entity--not only acts as a barrier, but carries a set of functional enzyme components, thus contributing to the interaction between compartments. Examples to illustrate this concept are enzyme systems involved in anaerobic glycine metabolism, aerobic utilization of carbon monoxide, proton or sodium translocation across the membrane, and intracellular hydrogen cycling used by the cell for the generation of a proton gradient.

Bacteria↗

PubMedDate not supplied

Analytic morphometry of the Trypanosoma cruzi (Bolivia strain) forms found in the intestine of Rhodnius prolixus.

Explore the source record for details and available documents.

Animals↗

PubMedDate not supplied

[Interpretation of the CA125 kinetics during first line chemotherapy of the ovarian cancer: methodological aspects and characteristic profiles].

Mathematical analysis of CA125 kinetics during first line chemotherapy allows calculation of various biologic parameters which are powerful indicators of the therapeutic efficiency. The purpose of this study is to present an original method of interpretation of CA125 kinetics based on both CA125 profile and its half-life value. The first part of this study reviews the practical modalities of CA125 kinetics analysis, the methods of calculation of the biologic parameters as well as the guidelines of interpretation. The second part of this work is dedicated to the presentation of CA125 profile characteristics in responders to chemotherapy, partially or totally nonresponders to chemotherapy, tumoral growth under treatment and tumor lysis syndrome.

Biomarkers, Tumor↗

PubMedDate not supplied

Phase II trial of trofosfamide in patients with advanced pretreated soft tissue sarcomas.

BACKGROUND: The number of cytostatic agents effective in patients with advanced soft tissue sarcoma is limited. Trofosfamide, an alkylating agent, has been shown to be effective in several solid and haematological tumors. PATIENTS AND METHODS: Eighteen patients with a median age of 57 years (range, 27-78) were treated with oral trofosfamide 300 mg/d for 1 week followed by 150 mg/d given continuously to analyze the efficacy and toxicity of continuous low-dose oral trofosfamide. All had received at least one anthracycline-based chemotherapeutic regimen prior to trofosfamide. RESULTS: Nine patients (50%) achieved stable disease lasting for a median of 5.5+ months (range, 1-9+). The median time to progression was 10+ weeks (range, 4-37+) and the median survival 7+ months (range, 2-13+). Toxicity was mild, grade III degree toxicity was seen in 5 patients (28%): 3/2 patients with anemia/neutropenia and 2 patients with fatigue syndrome. CONCLUSION: No objective remission was observed with oral low-dose trofosfamide in heavily pretreated soft tissue sarcoma patients, but almost half of the patients achieved disease stabilisation for half a year. The moderate toxicity profile observed in this study allows the consideration of trofosfamide as a reasonable palliative treatment option for patients with soft tissue sarcoma.

Administration, Oral↗

PubMedDate not supplied

Is genome mapping the way to improve Canadians' health?

Explore the source record for details and available documents.

Canada↗

PubMedDate not supplied

[Course of blood creatinine during repeated injections of cisplatin. Influence of drug combinations].

Cisplatin (CDDP) is known to induce nephrotoxicity. In this retrospective study, we have investigated the evolution of plasma creatinine in long term therapy with CDDP. We have studied case history, mode of administration of CDDP and associations with other chemotherapeutic agents or drugs which could potientiate CDDP renal damage (non steroidal anti-inflammatory agents, analgesics, antibiotics, antihypertensive agents, diuretics and contrast media). Mean creatinine concentration versus time rises significantly. This elevation is significantly higher in patients with hypertension, diabete, one functional kidney, or abdominoperineal irradiation. The association with other drugs has not proved a real influence on creatinine evolution.

Adolescent↗