Biomedical subjects
Publications and source records attributed to F Michelotti.
A case of primary congenital lymphedema is reported. Asymmetrical involvement of the low limbs and unremarkable family history for lymphedema (indicating of de novo mutation) was the main findings.
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In order to assess protection level against tetanus, the antitoxin titre was evaluated, by indirect haemagglutination test, in a sample, stratified by sex and age, of 805 subjects of three communes of Tuscany. On the whole the frequency of the serum protected is the 46.1% and it varies according to sex and age: under 20 years it is more than 90%, but it decreases in the successive ages, less in the male sex, probably owing to the vaccination made during the military service. The greatest percentage of immune subjects was observed in the most industrialized area. The less protected professional categories were pensioned people and housewives (25.8%). No differences of serum protection were found between those who practise or do not, recreative activities at the risk (sport, horticulture and gardening). No correlation was observed between the vaccinal anamnesis and the serological test.
A case of ectrodactyly characterized by simple absence of the third finger of the right hand is reported. Clinical and genetic aspects are considered.
The study of bile acids in the newborn permits to the AA. to point out that the beginning of the feeding does not influence the "physiologic cholestasis" of the first days of life. Neonatal cholestasis is the expression of the immaturity of bile acids synthesis and hepatic and intestinal carriage, which is not correlated with the maternal conditions. Furthermore, the AA. discuss about the analogy between cholestasis and "physiologic hyperbilirubinemia", from which it differs for the longer time. In fact, the maturation of the enterohepatic circle occurs very slowly under possible dietetic factors influences.
The authors present two case-studies of achalasia in infancy and the emphasize the rarity of the illness in this stage of life. They point out that a correct diagnosis requires a meticulous anamnesis which should be followed by a radiological, endoscopic and manometric study. The authors discuss their therapeutical experience with Nifedipine and they suggest that it should be used while waiting for surgery.
The authors report a case of Kawasaki disease observed in a 3-years and 6-months-old girl, with pericardial effusion and premature cardiac beats. The pericardial effusion disappeared after gamma-globulin i.v. treatment (2 gr/kg); the premature cardiac beats, although progressively reducing, completely disappeared only after 6 months.