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Biomedical subjects

F Milazzotto

Publications and source records attributed to F Milazzotto.

At least 19 recordsLinked to original sources
PubMed1992

Demonstration of the formation of hydroxyl radicals in acute myocardial infarction in man using salicylate as probe.

Dihydroxybenzoic acid (DHBA) derivatives of acetylsalicylic acid (ASA) are formed in vivo by the action of the hydroxyl radical (OH.). In order to evaluate the possible formation of OH(.) in acute myocardial infarction (AMI) in man, 9 consecutive patients with a first episode of AMI (8 males, 1 female, mean age 50.3 years), treated with rt-PA, and 8 healthy volunteers (7 males, 1 female, mean age 29.8 years) were studied. All subjects received 100 mg ASA p.o. daily; venous blood samples were taken 30 min after the first dose (time 0) and then at 3-, 6-, 12-, 24- and 48 h and 5 days. Serum was analyzed by HPLC and electrochemical detection for 2,3- and 2,5-DHBA contents. 2,3-DHBA was present in all subjects with AMI and undetectable in healthy volunteers at all time points studied. Serum levels of 2,5-DHBA did not show statistically significant differences between AMI patients and healthy volunteers. These data support the hypothesis that hydroxyl radicals are formed during AMI in man.

Aspirin↗
PubMed1992

Diastolic ventricular dysfunction in noncomplicated acute myocardial infarction: the influence of gallopamil.

The goal of this study was to assess the effect of gallopamil on left ventricular (LV) diastolic function early after acute myocardial infarction (AMI). Gallopamil was compared with placebo and atenolol in two different groups of patients. Study patients, 2 days after experiencing their first AMI, in Killip class I and stable sinus rhythm, were randomized in a crossover, double-blind sequence to receive (a) gallopamil (50 micrograms/kg over 5 min) or placebo (i.v. 10-ml bolus, with a time interval of 90 min); and (b) gallopamil (50 micrograms/kg over 5 min) or atenolol (5 mg over 5 min), with a time interval of 24 h. Group I and group II consisted of 28 patients (26 men and 2 women; mean age 55 +/- 9 years) and of 14 patients (13 men and 1 woman; mean age 56 +/- 10 years), respectively. All the patients were treated with thrombolysis within 6 h from the onset of symptoms. Doppler echocardiographic examinations were performed as follows: at baseline (B) and 15 min after administration of gallopamil bolus and placebo bolus, in group I; at baseline before gallopamil (BG) and atenolol (BA), and 15 min after each bolus in group II. The following echo-Doppler parameters were calculated, at each examination: the early and late transmitral peak velocity ratio (E/A), the early and late velocity integral ratio (Ei/Ai), the peak filling rate normalized to mitral stroke volume (nMPFR), and the LV isovolumic relaxation time (IVRT), which was normalized to an 800-ms R-R cycle length in the patients in group II. Mean blood pressure (MBP) and heart rate (HR) were also measured.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1991

[Pharmacological effects on left diastolic ventricular function in acute myocardial infarct: comparison of gallopamil and atenolol].

The aim of the study was to assess the effects of gallopamil and atenolol administration on left ventricular (LV) relaxation and filling in patients (pts) with acute myocardial infarction (AMI), by pulsed Doppler echocardiography (PDE). Two days after first AMI, 14 pts aged 56 +/- 10 years in Killip class I and treated with thrombolysis were randomized to gallopamil (50 mcg/Kg over 5 min) or atenolol (5 mg over 5 min) IV 10 ml bolus, with a 24 hour time interval, in a cross-over double blind sequence. Four PDE were performed in each patient: at baseline, before gallopamil and atenolol IV bolus, and a 15 min after each bolus. The following Doppler parameters were calculated: early (E) and late (A) peak filling velocities and their ratios (E/A), early (Ei), late (Ai) and total (TVi) diastolic filling time velocity integrals; the ratio between Ei and Ai (Ei/Ai), the peak filling rate normalized to mitral stroke volume (calculated as E/TVi [nPRP]), the percentage of atrial contribution to total diastolic filling (%AC), and the isovolumic relaxation time (nTRIV) normalized to an 800msec RR cycle length. Compared to baseline PDE evaluation, gallopamil administration significantly shortened nTRIV (89 +/- 13 vs 116 +/- 13 msec), improved early LV filling parameters (E: 74.5 +/- 14.0 vs 58.1 +/- 14.6 cm/sec; E/A 1.2 +/- 0.4 vs 0.9 +/- 0.3; Ei: 11.2 +/- 1.8 vs 8.9 +/- 2.0 cm; Ei/Ai: 1.8 +/- 0.6 vs 1.3 +/- 0.6; nPRP: 3.9 +/- 1.0 vs 3.5 +/- 1.0 SV/sec), and reduced %AC (35.6 +/- 8.8 vs 44.6 +/- 10.6). A and Ai were not significantly changed.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1990

Life expectancy in Italian track and field athletes.

Nine hundred eighty-three top Italian track and field athletes (700 males and 283 females) were examined for survival, mortality and causes of death for an average follow-up period of 18.6 years starting from their last year of competition as members of the national team. Overall mortality rates were compared to the rates expected on the basis of the life tables for Italian people of the same age, sex and time period. Thirty-four deaths were observed among males (vs 46.6 expected) with a O/E ratio of 0.73, while 3 deaths were observed among women (vs 6.2 expected) with a O/E ratio of 0.48. Neither of these differences was significant, but the O/E ratio for the group as a whole was quite significant (p = 0.0296). Some of the athletes demonstrated behavioural characteristics developed during their active careers that might have contributed to their low mortality rate.

Adolescent↗
PubMed1990

Effects of acute administration of gallopamil on left ventricular relaxation and filling dynamics in acute myocardial infarction assessed by Doppler echocardiography.

The purpose of this study was to assess the acute effect of an intravenous bolus of the calcium antagonist gallopamil on left ventricular diastolic function using Doppler echocardiography. Fifteen patients with acute myocardial infarction in the first Killip class and sinus rhythm were randomized to an intravenous bolus of gallopamil (50 micrograms/kg over 5 minutes) or placebo in a crossover sequence. Doppler echocardiography was performed at baseline and 15 minutes after each bolus. No patients had received calcium antagonists or beta blockers before the study; all patients received nitroglycerin, which was withdrawn at least 2 hours before the baseline Doppler echocardiogram. The following Doppler parameters were calculated: the early (E) and late (A) peak filling velocities, the velocities ratio (E/A), the diastolic filling time-velocity integral (TVI), the peak filling rate normalized to the mitral stroke volume (nMPFR), the isovolumic relaxation time (IVRT), and the systolic flow velocity integral (SFVI). Expressing the parameters measured after a gallopamil bolus as the percent change of those measured after placebo, E, E/A, and nMPFR increased by 25.5 +/- 11.5%, 30.6 +/- 15.5%, and 19.0 +/- 12.2%, respectively (p less than 0.001); IVRT decreased by 13.5 +/- 7.0% (p less than 0.001); and TVI increased mildly by 6.9 +/- 9.9% (p = 0.01). SFVI and A did not change significantly. Negligible differences were observed between placebo and baseline values. Heart rate, mean blood pressure, and left ventricular and atrial diameters did not change significantly. It was concluded that gallopamil infusion improves early left ventricular filling and relaxation in patients with acute myocardial infarction. Considering the unchanged loading conditions, this indicates an improvement in left ventricular diastolic performance.

Adult↗
PubMed1978

[The course of hypertrophic obstructive cardiomyopathy. A preliminary study of 40 cases (author's transl)].

The course of hyperthrophic obstructive cardiomyopathy in 40 patients was studied. The average follow-up of the patients (anamnestic and prospective) was 8 years. The age of the first diagnosis, the age of the first observation and the age of the detection of the first symptom, were considered. A prospective follow-up study was carried out in 31 patients, the average period of observation being 8 years. Functional capacity modifications, symptoms, clinical and electrocardiographic signs and the mortality rate were analyzed. Functional class unchanged in the most part of the patients; the overall mortality was 16% with high incidence of sudden and unexpected death. From our results it appeared that the prognosis could be related to the old age, heart failure and arrhythmias.

Adolescent↗
PubMed1978

[A study of the natural evolution of hypertrophic obstructive cardiomyopathy. Analysis of 100 cases (authors' transl)].

The authors present a study of the course of hypertrophic obstructive cardiomyopathy (C.I.O.), diagnosed both through noninvasive (52) and invasive (48 cases) techniques, in 100 patients. The average period of observation (prospective and retrospective) was 8.2 years; in 68 cases prospective inquiries were carried out over an average period of 4.6 years. In 80% of the cases the first symptoms occurred when the patient was under 40, while the first diagnosis and period of observation usually took place between the ages of 20 and 50. The results of this study confirm that CIO is an illness with a slow evolution; the following facts emerge: a) considerable stability of the symptoms; b) low yearly mortality rate (1.8%); c) high rate of survival 10 years after the first onset of the symptoms. The most frequent cause of death is usually sudden, which leads to the supposition that one of the most important elements for prognosis is the identification and treatment of arrhythmias.

Angina Pectoris↗
PubMed1978

[Analysis of Luciani-Wenckebach periodism in A-V node. I. Typical features (author's transl)].

Electrocardiograms of 20 patients developing Wenckebach A-V block duting atrial pacing and 20 with spontaneous Wenckebach block were reviewed to determine the frequency of typical features of classical Wenckebach periodicity. Few cases only met all six typical criteria. Cases with long cycles with conduction ratios of 5/4, with Wenchkebach point less than 130 min, and with first greater than A-H 110 msec were the most likely to show typical features. The implications of these observations are discussed on the basis of modern hypothesis of electrophysiological mechanisms of Wenckebach periodism.

Atrioventricular Node↗
PubMed1978

[Analysis of the Luciani-Wenckebach phenomenon in the A-V node. II. Relationship between conduction and recovery times].

We have studied 20 cases Wenckebach A-V block by atrial pacing. The relationships between conduction time and recovery time of N. AV Wenckebach point, basal A-H time and A-H time of first cycle beat were analysed. No correlation was found between W point, basal A-H and A-H of the first beat by analysing the A-H = f (H-A) we found different curves which occur when the first A-H is longer or shorter than 110. These data were discussed on the basis of modern hypotheses of electrophysiological mechanism of Wenckebach periodism.

Electrocardiography↗