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F Mills

Publications and source records attributed to F Mills.

7 recordsLinked to original sources

Sensory integration and teacher-judged learning problems: a controlled intervention trial.

Seventy-four children from 21 schools referred because of teacher-perceived learning difficulties and prescreened for sensory integration (SI) deficits were given tests of SI, reading, vocabulary, perceptuo-motor function and motor development, and their teachers rated their classroom behaviour. The results showed that the children suffered primarily from attention deficit disorder without hyperactivity, and from mild deficits of SI. They were then divided into two groups matched approximately for sex, school and degree of SI deficits. One group received no treatment while the other was given about 13 weekly SI sessions, each of 1 h duration. All children were then reassessed on the same set of measures. There were significant improvements with time in both treated and untreated groups on most measures except classroom behaviour. Only one measure showed a treatment effect, though this one was most reflective of SI theory.

Attention Deficit Disorder with Hyperactivity↗

Detection of a unique human V kappa IV germline gene by a cloned cDNA probe.

We have cloned the cDNA encoding the KIV chain of a human antibody with specificity against the major carbohydrate antigen of Streptococcus A. The cDNA has been used as a genetic probe to estimate the number of germline VKIV genes in human DNA. The presence of unique hybridizing bands on digestion of human DNA with several restriction endonucleases and the equivalence of the DNA in a band to a single gene per haploid genome point to the conclusion that there is a unique human VKIV germline gene. The corollary of this conclusion is that the diversity of human VKIV chains must be exclusively due to somatic mutation. This is supported by examination of the sequences of human KIV chain genes and their KIV chain products. Fusion of the unique germline VKIV gene (1) with one of several JK segments, followed by somatic mutations in the V region of the rearranged KIV gene, can account for the known sequences. The restricted germline gene repertoire may account for the small proportion of human KIV chains in the human K chain sequence library (2).

Amino Acid Sequence↗

I, the donor.

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Adult↗

Canadian contributions towards the comprehension of hyperinsulinism: the first successful excision of an insulinoma.

The authors review briefly the contributions to the "insulin story" made by Canadian doctors. A.G. Nichols from the department of pathology, McGill University, first described an adenoma arising from the islets of Langerhans. The authors also review the background to the first successful excision of a functioning tumour of the pancreas by R.R. Graham in 1929; in the preceding 2 years W. J. Mayo had found a malignant islet cell tumour with hepatic metastases and J.M.T. Finney had operated on a patient suffering from functional hypoglycemia. Graham found and successfully excised what was probably a solitary benign islet cell adenoma. The authors believe the patient was cured.

Adenoma, Islet Cell↗