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Biomedical subjects

F Minuto

Publications and source records attributed to F Minuto.

At least 91 records · Page 5Linked to original sources
PubMed1986

Evidence for an increased somatomedin-C/insulin-like growth factor I content in primary human lung tumors.

Immunoreactive somatomedin-C/insulin-like growth factor I (SM-C/IGF I) content was measured in human neoplastic lung tissue obtained from surgery on 10 patients (seven epidermoid carcinoma, three adenocarcinoma), and in normal lung tissue obtained from the same excised portion. SM-C/IGF I content in lung tumors was 615 +/- 123 (SE) milliunits/g of tissue (range, 214-1531), significantly higher (P less than 0.01) than normal tissue (234 +/- 51 milliunits/g of tissue; range, 37-537); in particular, every subject showed a clear-cut difference of SM-C/IGF I content between neoplastic and normal tissue (ratio, 3.41 +/- 0.69; range, 1.4-7.2). The results were essentially unchanged when data were expressed relative to hemoglobin or DNA tissue content. By contrast, in peripheral plasma SM-C/IGF I concentration was 0.51 +/- 0.17 units/ml, significantly lower (P less than 0.01) than in 59- to 70-yr-old control subjects (1.10 +/- 0.13 units/ml). In conclusion, the lung tumors studied, irrespective of their histological structure, contain more SM-C/IGF I than does normal tissue. Whether this is due to a primary in situ production of SM-C/IGF I or is secondary to overproduction of other inducers such as platelet derived growth factor-like peptides is yet to be clarified. The reduced circulating SM-C/IGF I concentration seems to be related more to the nutritional status of the patients.

Aged↗
PubMed1984

Multicentric experience on the acute effect of nomifensine in hyperprolactinemic women.

The inhibitory effect of nomifensine ( Nom ; 200 mg orally) on prolactin (PRL) secretion was studied in 15 subjects with puerperal hyperprolactinemia and in 59 pathologic hyperprolactinemic women. The latter were grouped as follows: i) patients with surgically proven PRL secretory pituitary adenomas (proven tumors; 27 cases); ii) patients presenting radiological signs of sella indicative of a pituitary tumor (presumptive tumors; 10 cases); iii) subjects with non-drug induced hyperprolactinemia (hyperprolactinemia of uncertain etiology; 22 cases). A mean PRL fall of 30% or more of baseline hormone levels in samples collected within the 120-240 min post-treatment interval was adopted to define responsiveness to Nom . In 24 out of 27 subjects with proven tumors and in 9 out of 10 subjects with presumptive tumors Nom did not induce significant variations in PRL secretion. In only 11% of the patients with surgery-confirmed or highly suspected tumors a hormone decrease greater than 30% was observed. In addition, 13 subjects with hyperprolactinemia of uncertain etiology did not respond to Nom administration. In 5 of these, additional data suggesting the existence of an adenoma were collected. Finally, 3 out of 9 Nom -responder patients presented either a polycystic ovary syndrome or transitory hyperprolactinemia. The finding that hyperprolactinemic women, who did not show clinical or radiological signs of a tumor and patients with highly presumptive or proven pituitary tumors may present comparable responses to Nom , suggests that this pattern may be indicative of an early manifestation of a PRL-secreting adenoma which has yet to evolve. The follow-up of Nom -non-responder hyperprolactinemic subjects who did not show clinical signs of harboring a tumor, is therefore advisable.

Adolescent↗
PubMed1984

Prolactin secretion in pubertal and adult male subjects.

Prolactin, LH and FSH circadian secretion were studied in a group of 20 boys in various pubertal stages and in 13 normal male adults. Prolactin 24-hour integrated concentration was similar in all groups except in stage 2 boys, in which it was significantly higher with respect to stage 3-4 boys. This pattern was observed also for nocturnal, but not for diurnal concentration. As already described by other authors, LH showed and amplified circadian secretion in stage 2 and 3-4 boys, particularly during night time. FSH increase was less evident, and reached the peak 24-hour mean concentration in stage 2 subjects. Our results suggest that during puberty the hypothalamic pituitary system increases its activity not only with regard to gonadotropins but also to prolactin secretion.

Adolescent↗
PubMed1984

In vivo and in vitro effect of liver on somatomedin generation.

The serum concentration of circulating somatomedins was measured in the blood of healthy donors and subjects with hepatic cirrhosis, and in culture media from in vitro explants of healthy and cirrhotic human liver. Serum levels of somatomedin bioactivity were significantly lower in cirrhotic subjects (0.42 +/- 0.03 U/ml; M +/- SEM) compared with age matched controls (0.99 +/- 0.03 U/ml). Radioreceptor assay of somatomedin concentrations confirmed this reduction in cirrhotic patients (0.89 +/- 0.06 U/ml) compared with controls (1.32 +/- 0.05 U/ml). A parallel reduction in somatomedin circulating binding ability was also observed (99.43 +/- 7.28% in cirrhotic and 123.5% +/- 10.8% in normal subjects). In vitro explants from normal human liver tissue produced a significant increase (0.57 +/- 0.09 U/ml) in somatomedin bioactivity contained in the medium (0.29 +/- 0.06 U/ml), while a decreased bioactivity (0.12 +/- 0.06 U/ml) was observed with explants of cirrhotic livers. These results support a role of liver in the biosynthesis of both somatomedin and somatomedin binding protein.

Adult↗
PubMed1982

Growth hormone secretion in pubertal and adult subjects.

GH responsiveness to insulin-induced hypoglycaemia and its circadian secretion were studied in a group of subjects in different pubertal stages. The GH peak after insulin was minimal in stage 1 boys (7.6 +/- 1.3 (SEM) ng/ml) and increased progressively, in parallel with pubertal maturation, reaching a maximum in the adult state (20 +/- 4.0 ng/ml); the basal value was superimposable in all groups studied. The circadian secretion showed a sleep-related surge which was almost identical in the different stages; however in pubertal stage 1 boys multiple secretory peaks were observed, mainly during waking hours. A statistically significant difference (P less than 0.05) was observed in the mean concentration recorded during the day with a maximum in stage 1 boys (2.7 +/- 0.2 ng/ml) and a gradual decrease to a minimum in adults (1.2 +/- 0.3 ng/ml). This pattern seems to suggest that pulsatile rhythm is present in boys, similar to that observed for gonadotrophins.

Adolescent↗
PubMed1981

Decreased serum somatomedin C concentrations during sleep: temporal relationship to the nocturnal surges of growth hormone and prolactin.

Serum concentrations of immunoreactive somatomedin C, GH, and PRL were determined on samples obtained from 16 adult subjects throughout the day. Samples were collected by a portable continuous flow, blood withdrawal pump. Somatomedin C concentrations were stable during waking hours [1.13 +/- 0.09 U/ml (mean +/- SE)] but fell after the onset of sleep to a minimum value of 0.85 +/- 0.08 U/ml. After awakening, the concentration rose progressively to a mean of 1.26 +/- 0.10 U/ml between 1100-1200 h. These changes were statistically significant. There were no sex differences in the sleep-related decrement. The secretion of GH showed the expected surge in the first hours of sleep, and PRL concentrations were higher in the late phases of sleep or immediately after awakening. In sleep reversal experiments, three subjects who were deprived of sleep had a modest, slightly delayed fall in somatomedin C but no secretory peaks of GH or PRL. After the delayed onset of sleep, somatomedin C declined sharply as human GH concentrations rose.

Adolescent↗
PubMed1977

Effect of metoclopramide on prolactin secretion in man.

Prolactin (PRL) secretion was studied after i.m. administration of Metoclopramide (alone or with a pretreatment with 5-Br-2alpha-ergo-cryptine) and after i.m. administration of Sulpiride. The results obtained evidenced a considerable hPRL increase after Metoclopramide administration, similar to that observed with Sulpiride, completely abolished by 5-Br-2alpha-ergocryptine. On the basis of these data it seems evident a strong and specific effect of Metoclopramide on hPRL secretion, probably more potent than Sulpiride.

Adolescent↗
PubMed1976

Growth hormone and somatomedin behaviour in the newborn.

Human growth hormone (HGH) and somatomedin (Sm) concentrations have been studied in a group of newborns. Plasma HGH values were 41.17 +/- 24.26 (SD) ng/ml (14.00-90.00 ng/ml) and the Sm value was 0.59 +/- 0.43 (SD) U/ml (0.18-1.8 U/ml); the difference between these values and the ones observed in normal adults (2.45 +/- 2.53 (SD) ng/ml and 1.16 +/- 0.28 (SD) U/ml respectively) were statistically significant. While growth hormone values were higher than in normal adult controls, somatomedin was significantly decreased. It is possible that the dissociation between human growth hormone and somatomedin in newborn could reflect a reduced biosynthesis of the somatomedin-generating system and consequently a lack of a feed-back control on GH exerted by somatomedin.

Age Factors↗