PubMed Health⌕ Search

Biomedical subjects

F Miralles

Publications and source records attributed to F Miralles.

59 records · Page 4Linked to original sources
PubMedDate not supplied

[Determination of basal GH in dementias].

We have studied the plasmatic levels of the growth hormone (GH) in a control group consisting of 72 subjects with an average age of 69.7 +/- 8.4 years and in a group of 37 patients with an average age of 69.3 +/- 9.6, of which 28 were demented (15 with degenerative dementia and 13 with non-degenerative dementia); 8 suffered from Parkinson's disease, and the rest showed signs of failing memory due to age. When comparing the plasmatic levels of GH between the patients' group and the control group we did not find significant differences between the demented and the control group, nor between the sub-groups of non-degenerative dementia or of those suffering from Parkinson's disease, when compared to the control group. However, we did find a reduction of GH that was statistically significant in the sub-group of degenerative dementia and the control group. This reduction in GH plasmatic values indicates a specific alteration in this type of process, which may be of certain use when searching for a hormonal marker for degenerative type dementia.

Aged↗
PubMedDate not supplied

[Hormonal markers of stress in acute cerebrovascular pathology].

Various studies carried out over the last decade have shown that high glucose levels in the blood foster ischaemic brain damage associated with a worse evolution of such pathologies. The aim of the study we performed was to try to shed some light on whether stress in these patients raised their glucose levels adding to a worsening of the patient's clinical picture. We studied 318 consecutive patients suffering from stroke. We determined fasting glucose levels, prolactin and cortisol within the first few hours of hospitalization and afterwards at seven to ten days and again at one month after the stroke. Clinical severity was evaluated using Toronto and Mathew neurological scales and the degree of incapacity was measured using the Barthel functional scale on the three aforementioned occasions and Rankin's modified scale six and twelve months after the stroke. Clinical severity the first hours after stroke was significantly related to glucose levels, such relationship not being observed with prolactin and cortisol. Nor did we observe any significant association between glucose and these hormones. Likewise the anxiety scale had no relationship with any hormone. Studying medium and long term functional incapacity, glucose significantly correlated with the Rankin scale although with low dependence, such a relationship not being found either with prolactin or cortisol. Our work would seem to indicate that blood glucose behaviour is independent of prolactin and cortisol levels since we found no such relationship between them.

Aged↗