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Biomedical subjects

F Moesgaard

Publications and source records attributed to F Moesgaard.

101 records · Page 6Linked to original sources
PubMed1981

A case with severe diarrhoea and Strongyloides stercoralis infection.

A case with severe diarrhoea and Strongyloides stercoralis infection is described. Further examination showed that the patient also had abnormal colonization of the duodenum with Hafnia alvei and that this disappeared when the Strongyloides infection was treated with mebendazole. Symptoms such as abdominal pain, diarrhoea, "skin rash" and malabsorption in association with blood eosinophilia should arouse suspicion of strongyloidiasis.

Adult↗
PubMed1981

Bioassay of clindamycin in bile.

This study compares different preparations of standard solutions for determining clindamycin in bile. Pooled human serum, ox bile, 10% human bile, and 0.1 M phosphate buffer were compared, and pooled human bile was serving as reference standard curve. The use of pooled human serum and ox bile resulted in a considerable error of overestimation of clindamycin in bile. An error of underestimation occurred when 10% human bile or 0.1 M phosphate buffer was used as a standard solution. It is concluded that none of the different preparations tested are acceptable substitutes for human bile.

Animals↗
PubMed1981

Wound sepsis after elective cholecystectomy. Restriction of prophylactic antibiotics to risk groups.

This prospective study of elective cholecystectomy investigated the frequency and type of bacteria in gallbladder bile at operation, the factors predicting the presence of bacteria in bile, and the relationship between bacteria in bile and subsequent wound sepsis. In 148 consecutive cases 23% of bile cultures were positive. The overall wound infection rate was 15%, but 91% of all wound infections occurred in patients with positive bile cultures. Eighty-five per cent of all positive bile cultures and 86% of all wound infections occurred in 37% of the patients, characterized by age over 60 years and/or a history of previous attacks of acute cholecystitis. We suggest that in elective cholecystectomy prophylactic antibiotics should be restricted to this group of patients to limit the use of antibiotics.

Age Factors↗
PubMedDate not supplied

Pancreaticoduodenectomy for periampullary cancer in patients more than 70 years of age.

BACKGROUND/AIMS: To assess the indications for and results of pancreaticoduodenectomy in patients more than 70 years old with periampullary cancer. METHODOLOGY: Thirty-four consecutive patients older than 70 years with periampullary cancer. The surgical procedure was pancreaticoduodectomy (Whipple's operation) with an extensive dissection of lymph nodes and the connective tissue in the peripancreatic region. Main outcome measures were postoperative morbidity and mortality, median and 5-year survival rates. RESULTS: Postoperative medical complications occurred in 24% and surgical complications in 53% of the patients. Four patients (12%) died in the postoperative period (within 30 days), and 3 patients (9%) died later in the postoperative course. The cumulative and age corrected 5-year survival rate for the remaining patients was 26%. Fifteen patients died of recurrence, and 7 patients of other causes. Five patients are still alive more than 5 years after surgery. In patients with noncurative operation the median survival time was 1 1/2 years, which is longer than would be expected from other palliative procedures. Apart from a moderately increased postoperative mortality the results were similar to those reported for younger patients. CONCLUSIONS: Pancreaticoduodenectomy should be considered in patients older than 70 years with resectable periampullary cancer. A 5-year survival rate of 20-35% can be obtained. Palliative resection may be indicated in patients in good general condition, as resection gives the best palliation and longer survival than other palliative methods.

Adenocarcinoma↗
PubMedDate not supplied

Antibiotic prophylaxis in high risk biliary surgery: one dose of ceftriaxone compared with two doses of cefuroxime.

In a controlled trial 219 high risk patients undergoing biliary surgery were allocated at random by sealed envelopes to one of two treatment groups. Group I (n = 112) received a single dose ceftriaxone 1 g intravenously at the time of skin incision, and group II (n = 107) was given cefuroxime 1.5 g intravenously at the time of skin incision, followed by a second dose eight hours later. There were no significant differences between groups in age, sex, diagnosis, or operations carried out. There were three wound infections in group I (3%) and four in group II (4%) (p = 0.65). One patient in group I and two patients in group II developed intra-abdominal abscess and septicaemia (0.9% and 1.9%, respectively). Five patients developed pneumonia postoperatively in group I (5%) and six in group II (6%) (p = 0.65). There was no significant difference of the total number of postoperative infectious complications (wound infection, intraabdominal abscess, septicaemia, and pneumonia) between the groups (p = 0.42). A single dose of ceftriaxone given intravenously at skin incision was as effective as two doses of cefuroxime for the prophylaxis of wound infection in this high risk group of patients.

Abscess↗
PubMedDate not supplied

Preoperative cell-mediated immunity and duration of antibiotic prophylaxis in relation to postopertive infectious complications. A controlled trial in biliary, gastroduodenal and colorectal surgery.

In a prospective controlled trial, 750 patients undergoing elective biliary, gastric or colorectal surgery were randomized to receive short-term or long-term antibiotic prophylaxis--cefotaxime for biliary or gastric, and gentamicin/metronidazole for colorectal operations. In all patients, delayed cutaneous hypersensitivity was preoperatively assessed by simultaneous application of seven standardized recall antigens. Positive reaction was defined as mean diameter greater than or equal to 2 mm, anergy as no positive reaction to any antigen, and a 'score' as the sum (in mm) of all the mean diameters of positive reactions. There was no significant difference in septic complication or mortality rates following short-term vs. long-term prophylaxis. Anergy was found in 21 patients (2.8%), while 63 (8.4%) scored 2-4 and 666 (88.8%) greater than or equal to 5. The incidence of postoperative infectious complications was 25% in the patients with score less than 5 and 10% in those scoring greater than or equal to 5, and the corresponding mortality was 14.3 and 2.1% (both p less than 0.001). In the group with preoperative scores less than 5, the duration of antibiotic prophylaxis influenced neither postopertive infectious complications nor mortality.

Adult↗
PubMedDate not supplied

Linear incision and curettage vs. deroofing and drainage in subcutaneous abscess. A randomized clinical trial.

Linear incision plus curettage under antibiotic cover was compared with conventional deroofing and drainage of subcutaneous abscess in a randomized study of 50 patients. The median healing time was 9 days following linear incision and curettage and 15 days after deroofing and drainage (p less than 0.05). There was no recurrence of abscess during follow-up for 6 months. Linear incision plus curettage under single-dose antibiotic cover thus proved to be a safe method with significantly shorter healing time than after conventional deroofing an drainage.

Abscess↗