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Biomedical subjects

F Moll

Publications and source records attributed to F Moll.

At least 19 recordsLinked to original sources
PubMed2006

[The 100th anniversary of the German Society for Urology].

Medical thought followed the general acceptance of scientific method in the mid-19th century with the foundation of specialist areas. In Vienna, urology was established very early as such a specialist area along with surgery. At the beginning of the 20th century, however, urology was still taught under the specialist areas of dermatology or surgery in universities in Berlin and other German cities. With the foundation of "modern urology" the battle for recognition as an independent specialist area began. Urology's origins are to be found in the two classical disciplines surgery and internal medicine as well their two older daughter specializations of gynecology and dermatovenerology. In September 1906, the German Society for Urology was founded, exactly 10 years after a first attempt had been made. In 1907 the "Zeitschrift für Urologie" (Journal for Urology) was founded.

Germany↗
PubMed2006

Chordin is underexpressed in ovarian tumors and reduces tumor cell motility.

Ovarian cancers mostly derive from the monolayer epithelium that covers the ovary. There are currently very few molecular clues to the etiology of this cancer. Bone morphogenetic proteins (BMPs) are required for follicular development and female fertility and are expressed in the ovarian surface epithelium (OSE). We previously reported the expression of human chordin (CHRD), a BMP extracellular regulator, in the ovary. Here we show that CHRD is underexpressed in epithelium ovary cancer and epithelial cancer cell lines as compared with normal tissues and OSE, respectively. Besides, we detected BMP expression in all ovarian cell lines analyzed. To determine the functional relevance of the absence of CHRD mRNA in tumors and cancer cell lines, we studied the effects of CHRD on two cancer cell lines, BG1 and PEO14. Migratory and invasive properties were greatly reduced, whereas cell adhesion to the support was enhanced. In addition, we detected chordin (Chrd) expression in OSE of rat ovaries in a pattern similar to that of BMP4. Altogether, these results suggest that CHRD could participate in regulating BMP activity in normal OSE physiology, and that its mis-expression in OSE may facilitate cancer incidence and/or progression.

Animals↗
PubMed2006

Towards a VR trainer for EVAR treatment.

Endovascular repair of aortic abdominal aneurysms (AAA) is more and more becoming part of clinical practice. Up to approximately 30 clinical procedures however are necessary to obtain the surgical skills to make the procedure reliable and safe. The current study aims to generate a VR trainer to speed up the training process of experienced vascular surgeons to become experienced EVAR (endovascular AAA repair) surgeons by introducing a VR environment. This manuscript describes the contents and validation of the first step in the VREST - EVAR trainer, i.e. the proper definition of the knowledge and skills that need to be transferred.

Aortic Aneurysm, Abdominal↗
PubMed2006

Remote superficial femoral artery endarterectomy and distal aSpire stenting: results of a multinational study at three-year follow-up.

AIM: The aim of this study was to examine the results of remote superficial femoral artery endarterectomy (RSFAE) in conjunction with distal aSpire stenting in a multinational study. METHODS: RSFAE is a minimally invasive procedure performed through a limited groin incision. A total of 210 patients were included in this study. The indications for the procedure were claudication in 158 (75%) patients and limb salvage in 52 (25%). After RSFAE the outflow tract atheromatous plaque was ''tacked'' with the aSpire stent, which is an expanded polytetrafluoroethylene (ePTFE) covered nitinol stent with high radial strength, yet it is flexible enough to withstand the compressive forces at the knee joint. Prior to stent deployment, if the stent position is not in optimal position, it can be ''wrapped down'', repositioned and re-expanded. Therefore, not only is the plaque end point tacked, but the collaterals are preserved as well. All patients underwent follow-up examination with serial color-flow duplex ultrasound scanning. RESULTS: The mean length of endarterectomized superficial femoral arteries (SFAs) was 28.2+/-6.2 cm (range 15-43 cm). The primary cumulative patency rate by means of life-table analysis was 60.6+/-4.8% (SE) at 33 months, (mean 17.1 months; range 1-33 months). During follow-up percutaneous transluminal balloon and/or stent angioplasty was necessary in 50 patients for a primary assisted patency of 70.2+/-4.8% at 33 months. The locations of the restenosis after RSFAE were evenly distributed along the endarterectomized artery. There were 2 deaths (myocardial infarctions), 12 (5.7%) wound complications (7 hematomas, 5 skin edge sloughs) and the mean hospital length of stay was only 1.3+/-0.5 days. CONCLUSION: RSFAE with distal aSpire stenting is a minimally invasive, safe durable procedure for the treatment of long-segment SFA occlusive disease.

Adult↗
PubMed2005

[Possible treatments for patients with symptomatic carotid artery stenosis].

The classical treatment for severe and symptomatic stenosis of the internal carotid is carotid endarterectomy. An endarterectomy within two weeks after the initial symptoms of a TIA or CVA decreases the chances of new ischaemic symptoms. However, there is now an alternative for this operation, namely the placement of an endovascular stent. Although this method offers some advantages, there are still insufficient prospective randomised trials to prove that this technique is just as suitable as the classical method. Various studies are now in progress to evaluate the short- and longterm results of endovascular treatment in comparison with endarterectomy. For the time being, therefore, stent placement should only be done in the context of clinical trials.

Carotid Artery, Internal↗
PubMed2005

[Gustav Simon--Surgery of the kidneys].

In the English-speaking world anthologies about "classic works in urology" have been en vogue for years and have been published several times, but they do not exist in Germany. Due to the short half-life of knowledge, these pioneering publications were forgotten and are not readily available or easily accessible. Furthermore, for reasons of preservation libraries do not allow borrowing these old books or copying them. These articles thus remain inaccessible to the public. The work of the famous Gustav Simon ranks along with Nitze's "Kystoscopy" among the most important works for our specialty. The Museum and Archives of the German Urologic Society, located at the head office in Dusseldorf, has a well-renowned collection of papers, monographs, and books from across the centuries.

Germany↗
PubMed2004

Transcriptional and posttranscriptional regulation of fibulin-1 by estrogens leads to differential induction of messenger ribonucleic acid variants in ovarian and breast cancer cells.

Fibulin-1 is an extracellular matrix protein overexpressed in epithelial ovarian and breast cancers. In estrogen receptor (ER)-positive ovarian and breast cancer cell lines, fibulin-1 mRNA levels are markedly increased by estrogens. Transfection experiments using fibulin-1 promoter constructs indicate that 17beta-estradiol (E2) increases fibulin-1 gene transcription and that ERalpha is more potent than ERbeta to mediate E2 regulation of the transfected fibulin-1 promoter. Using SL2 cells devoid of specificity protein 1 (Sp1) and site-directed mutagenesis of GC boxes, we evidenced that the E2 regulation occurs through a proximal specificity protein 1 binding site. In addition, we show that fibulin-1C and -1D mRNAs, the two major fibulin-1 splicing variants, are differentially induced by E2. The induction of both mRNAs variants is direct and independent of a newly synthesized protein intermediate. Interestingly, actinomycin D chase experiments demonstrate that E2 treatment selectively shortens the fibulin-1D mRNA half-life. This indicates that estrogens affect differentially the stability of fibulin-1 variants and may explain the lower accumulation of fibulin-1D mRNA on E2 treatment. In conclusion, our data show that estrogens, via ERalpha, are key regulators of fibulin-1 expression at both the transcriptional and posttranscriptional levels. The preferential induction of the fibulin-1C variant, which is overexpressed in ovarian and breast cancer, might play an important role in estrogen-promoted carcinogenesis.

Base Sequence↗
PubMed2003

[Diaphragmatic traumatic chronic hernia. Report of 3 cases].

Diaphragmatic traumatic chronic hernias are infrequent. Diagnostic can be difficult if don't exist suspicion and treatment is always by surgery. The aim of this paper is to present three cases and makes an actualisation in basis to our experience and the literature.

Aged↗
PubMed1999

The surgeon and his intention: Gustav Simon (1824-1876), his first planned nephrectomy and further contributions to urology.

One of the historic landmarks in urology is the first planned nephrectomy performed in 1869 by Gustav Simon of Heidelberg (1824-1877). In the history of medicine the reflections and considerations of the specialized surgeon reveal distinguished analyses of the "case" and, thus, the beginning of a modern scientific discussion of a patient's quality of life. Available primary and secondary sources were screened to present a differentiated aspect of this milestone in the history of urology. The analysis of the first German indicated nephrectomy shows the introduction of scientifically orientated thinking in urology, especially in Germany during the middle of the nineteenth century, and parallels the rise of urology and general surgery.

Germany↗
PubMed1999

Robotic computer-assisted telemanipulation enhances coronary artery bypass.

OBJECTIVES: Totally endoscopic coronary artery bypass grafting depends greatly on perfecting the anastomosis. We tested a new computer-assisted telemanipulation robot (Intuitive Surgical Inc, Mountain View, Calif) in performing endoscopic coronary bypass. METHODS: On-bench anastomoses of the porcine arterial graft to the left anterior descending coronary artery were performed with both direct visualization and conventional surgical instruments (group I), endoscopic 3-dimensional visualization and current endoscopic surgical instruments (group II), direct visualization and endoscopic instruments (group III), 3-dimensional endoscopic visualization and conventional surgical instruments (group IV), and telemanipulation robotic with 3-dimensional endoscopic visualization (group V). Anastomoses (n = 6 in each group) were assessed for time (minutes), quality (good = 3, fair = 2, poor = 1), technical difficulty (easy-difficult: 1-4), and patency (100% = 1, >50% = 2, <50% = 3). RESULTS: Anastomotic time was significantly longer in groups II and III than in groups IV and V (P </=.02). Patency was comparable in all groups. CONCLUSION: Telemanipulation technology may enhance the performance of totally endoscopic coronary artery anastomosis. The facility and time of an Intuitive telemanipulation anastomosis is comparable with that of a conventional anastomosis created under direct vision.

Anastomosis, Surgical↗
PubMed1998

Controlled iontophoretic release of glucocorticoids through epithelial cell monolayers.

In the present study the iontophoretic transdermal delivery of three different glucocorticoids through a confluent monolayer of MDCK cells, mimicking biological barriers, was studied. For this experiment an in vitro model with platinum electrodes for iontophoresis and MDCK cells was developed. With this model investigations concerning the biocompatibility of the cells depending on different current densities and the iontophoretic permeation of the three glucocorticoids through the cell monolayer were carried out. The permeation behavior of this living biological barrier should be very similar to the non-living barrier, human stratum corneum. Different current densities (12.74-38.22 microA/cm2) and a pulsatile application of continuous current to the cell monolayer were investigated. The pulsatile application of the current resulted in a step-like permeation profile. In all cases the electric current induced an reversible increase of the porosity of the cell monolayer demonstrated by transepithelial electrical resistance measurements and by sodium fluorescein assay.

Administration, Cutaneous↗
PubMed1998

[Infrared A radiation-controlled permeation of tetracaine in vitro and in vivo].

Waterfiltered infrared light (IR-A) was investigated as permeation enhancer for transdermal drug delivery systems on biological membranes. Due to the IR-A-radiation pulse on human keratinocytes (HaCaT) a clear increase in the permeability of tetracaine was recognizable. In vivo studies showed IR-A-supported enhanced local analgesia of tetracaine hydrogel in the pin prick test. The study leads to the conclusion, that IR-A-radiation can specifically be used to optimize transdermal drug permeation.

Administration, Cutaneous↗
PubMed1996

[Phonophoretic permeation of procaine hydrochloride through an MDCK cell monolayer].

With the aid of permanent cultured MDCK (Madin Darby Canine Kidney) epithelial cell a model for investigations dealing with phonophoresis effects was developed. The permeation of procaine hydrochloride through cell monolayers was examined while applying therapeutical ultrasound simultaneously. It could be shown that this permeation follows Higuchi kinetics. A comparison of the velocity factors, using a continuous irradiation of 1.0 W/cm2, shows about a 4.8 fold increase. Single Ultrasound pulses, however, result in a short-time enhancement of the permeation. The conclusion can be drawn that extent and velocity of the permeation of the permeation of procaine hydrochloride through MDCK monolayer can be controlled by phonophoresis.

Anesthetics, Local↗
PubMed1996

[Current strategies in patients with urinary diversion, I: the lower urinary tract].

Urethral catheterization, intermittent self-catheterization and suprapubic catheters are reliable methods to drain the urine in the lower urinary tract. Only a strict indication for indwelling catheters can minimize the complications and negative side effects. All physicians, especially pediatricians, surgeons, neurologists and internists should be familiar with the problems of catheter drainage by using a strictly aseptic technique.

Aged↗