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Biomedical subjects

F Mor

Publications and source records attributed to F Mor.

66 records · Page 4Linked to original sources
PubMed1987

Myopathy in Addison's disease.

Since the first description of primary adrenocortical insufficiency by Thomas Addison in 1855 several large series of patients with Addison's disease have been published. The common signs and symptoms include: weakness, hyperpigmentation, weight loss, gastrointestinal complaints, and hypotension. It is rare for patients with Addison's disease to present with musculoskeletal symptoms including flexion contractures, hyperkalaemic neuromyopathy, Guillain-Barré syndrome, migratory myalgia, sciatica-like pain, and low back pain. Myopathy has not been previously described in Addison's disease. Herein we report a patient presenting with severe hyponatraemia and myopathy which resolved after steroid replacement therapy.

Addison Disease↗
PubMed1987

Rhabdomyolysis in self-induced water intoxication.

A 64-year-old patient with major depression who developed self-induced water intoxication associated with rhabdomyolysis is presented. The possible link between acute hyponatremia and muscle injury is discussed and previous reported cases with this association are reviewed. The importance of recognizing this complication in patients with water intoxication is stressed.

Acute Disease↗
PubMed1987

Leukocytoclastic vasculitis in malignant lymphoma. Case report and review of the literature.

A 76-year-old patient presenting with leukocytoclastic vasculitis and later diagnosed as having diffuse immunoblastic lymphoma is presented. The clinical data of patients with leukocytoclastic vasculitis and lymphoproliferative disease reported in the literature are summarized. Other diseases associated with this form of vasculitis and the proposed pathogenesis are briefly discussed.

Aged↗
PubMed1985

Imipramine for the treatment of fibrositis: a therapeutic trial.

Twenty fibrositic patients were treated with imipramine 50-75 mg/day. Only two patients responded favourably. Nineteen patients stopped therapy during the initial three-month period: 14 of them due to lack of response, while two of these concomitantly disclosed side effects. The additional five patients stopped therapy mainly due to side effects, while only one of them improved with therapy. One patient, only, improved and adhered to therapy for more than three months.

Adult↗
PubMed1985

Addison's disease due to metastases to the adrenal glands.

A 43 year old patient with Addison's disease secondary to extensive metastases to both adrenal glands is presented. Thirty two previously reported cases are reviewed; in only 13 cases was the diagnosis of Addison's disease confirmed biochemically. Reasons for the apparent rarity of Addison's disease in spite of the frequency of adrenal metastases are discussed. The need to consider the possibility of Addison's disease complicating known malignant disease arising in other tissues is stressed.

Addison Disease↗
PubMed1981

Relationship between systolic time interval measurements and the extent of regional ventricular asynergy in coronary artery disease.

Systolic time interval (STI) measurements were made in 44 patients with coronary artery disease: 38 had regional left ventricular (LV) asynergy, and the remaining 6 had normal ventricular contraction patterns on left ventricular angiography. There was a significant correlation between both the preejection period (PEP) (r = 0.70) and the PEP/LVET (LV ejection time) ratio (r = 0.66), with the extent of regional ventricular dysfunction measured quantitatively on the left ventricular angiogram (P less than 0.001). A PEP/LVET ratio greater than 0.50 was associated with ventricular asynergy involving more than 40% of the LV circumference at end diastole. STI measurements also correlated with ejection fraction but not with ventricular end diastolic pressure nor with the number of obstructed coronary arteries.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

Significance of elevated levels of serum creatine phosphokinase in febrile diseases: a prospective study.

The incidence and significance of elevated serum levels of creatine phosphokinase (CPK) in febrile diseases were studied prospectively in all patients admitted with fever to a department of medicine during 1 year. High serum CPK levels were detected in 70 (28%) of 247 febrile patients but in only six (6%) of 105 afebrile control patients (P = .0001). Elevated CPK levels were not related to any specific diagnosis. Logistic regression analysis identified five factors that correlated both significantly and independently with elevation of CPK values: increased blood urea nitrogen level, low serum phosphate level, a stuporous or comatose state, tremor, and muscle tenderness. Myoglobinuria, detected in 14 patients, was predictive of a fatal outcome, but a high CPK level by itself was not an independent correlate of mortality. In summary, CPK elevation is not uncommon in febrile diseases, but because it does not reflect a specific etiology it does not necessarily indicate that an extensive diagnostic work-up is required.

Adult↗
PubMedDate not supplied

The significance of paraproteinemia in hairy cell leukemia: case report and review of the literature.

A case of hairy cell leukemia and IgG paraproteinemia is described. Peripheral blood surface marker analysis, serum paraprotein levels and immunoperoxidase stains of bone marrow sections at diagnosis and after 7 months of interferon treatment suggested the existence of two unrelated pathological B cell clones: one composed of malignant hairy cells and the other secreting the paraprotein. Previously reported cases of hairy cell leukemia with paraproteins are reviewed and our patient's contribution to the understanding of this association is stressed.

Aged↗
PubMedDate not supplied

Experimental aspects of T cell vaccination.

In the last 10 years, our laboratory has investigated the role of T cells in the induction and therapy of experimental autoimmune diseases. In several animal model T cell lines and clones that were expanded in vitro by repeated culture with the autoantigen were found to be pathogenic. Inoculation of pathogenic T cells after attenuation resulted in protection of the animals against a future attempt to induce the disease: this form of therapy was termed T cell vaccination (TCV). Several forms of TCV were developed, including the administration of T cell lines attenuated by irradiation or mitomycin C, membrane modified cells and sub-pathogenic doses of unmodified T cells. The vaccinating effect was found to be mediated by T cells. Vaccinated animals had both CD4 T cells that responded to the vaccine and CD8 T cells that suppressed its response to the autoantigen. The major obstacle to the clinical application of TCV in human autoimmune diseases is the fact that the nature of autoantigens initiating and perpetuating the disease are not known.

Animals↗