[Multiple organ procurement: Lausanne experience].
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Biomedical subjects
Publications and source records attributed to F Mosimann.
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167 of 189 patients were followed prospectively after sclerotherapy of oesophageal varices between 1982 and 1989. 18% developed a stenosis of the lower oesophagus causing dysphagia: 3 of these 30 strictures were malignant and 27 were benign. The former are probably not related to sclerotherapy. 17 of the latter responded to a modified diet and the other 10 required endoscopic dilatation. This was done successfully on an out-patient basis without complication in all cases. We conclude that dysphagia after sclerotherapy of oesophageal varices is common; it is usually caused by a benign stricture: if severe, it responds to endoscopic dilatation.
We tested the laxative sodium picosulfate for mechanical bowel preparation in elective colorectal surgery. The quality of this preparation was assessed on a visual analog scale on 277 patients who were then followed prospectively for wound and intraabdominal infectious complications for 42 days. Picosulfate preparation resulted in a complication rate similar to whole gut irrigation but was more acceptable for the patients and the nurses.
We operated 5 patients with the Budd-Chiari syndrome or veno-occlusive disease between 1984 and 1989 (2 porto-caval shunts, one Warren distal spleno-renal shunt, one meso-atrial shunt and one Le Veen peritoneo-jugular shunt). As liver transplantation is now part of the therapeutic armamentarium for these conditions, this paper reviews retrospectively the indications for surgery in these 5 patients.
From 1969 to 1990, 52 patients underwent splenorenal shunt after one or more esophageal variceal hemorrhages. Sixty days' mortality was 15.4% (8 deaths). 3 patients were lost to follow-up soon after hospital discharge. The remaining 41 patients could be followed for 5.5 years on average: 26 died, 3 were lost to follow-up late after discharge and 12 are presently alive. Only 4 of the followed-up patients suffered recurrent bleeding due to a thrombosed shunt. Temporary mental disturbances were noted in 4 cases but no incapacitating encephalopathy was recorded. In the last 10 years, performance of the Warren shunt has decreased strikingly as a result of the increasing popularity of endoscopic sclerotherapy. Surgical and anesthetic techniques have, however, improved too, resulting in a lower morbidity and mortality rate. Recurrent bleeding and neurological sequelae being rare, we conclude that distal splenorenal shunt remains a valuable alternative to long-term sclerotherapy in selected cases.
This paper presents the results of the first 7 orthotopic liver transplants performed in Lausanne between December 1988 and September 1990. 6 patients are surviving; their rehabilitation is excellent.
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We report the case of a patient who developed herpes simplex oesophagitis less than one month after renal transplantation. Graft rejection treatment may have induced this infection. Diagnosis was suspected at endoscopy and was confirmed by biopsy. The patient was cured by intravenous acyclovir and temporary discontinuation of immunosuppressive medication.
Endoscopic sclerotherapy is now the treatment of first choice for oesophageal varices. However, in spite of its efficiency and safety, recurrent bleeding remains possible and oesophageal sclerosis does not cure other potentially incapacitating symptoms related to portal hypertension. This report describes four adolescents with prehepatic hypertension for whom sclerotherapy was inadequate. They were treated successfully by an autologous internal jugular vein interposition mesocaval shunt. This operation is safe, decompresses the whole splanchnic territory and obviates the need for long term endoscopic surveillance.
Cystic neoplasms of the pancreas are rare and their diagnosis and treatment can be difficult. This report details 7 patients who had histologically proven serous cystadenoma, mucinous cystadenoma and cystadeno carcinoma. Computed tomography and sonography allowed excellent preoperative assessment but to attempt a distinction between the histological variants may be hazardous. Two tumours were only autopsy findings and 5 patients underwent laparotomy. It is confirmed that potentially malignant mucinous cystadenomas and cytadenocarcinomas should be resected whenever possible; serous cystadenomas are always benign and should therefore be resected only when the diagnosis is doubtful or if they cause symptoms.
In 1987, two media campaigns were organized in Switzerland to promote donor cards. The purpose of this study was to test their impact on the medical community. Questionnaires were sent to qualified practitioners, doctors in training and intensive care nurses. It is concluded that the campaigns for organ donation must be repeated and that their quality can be improved. It is however more urgent to improve the level of knowledge among doctors and other health professionals.