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Biomedical subjects

F Murillo

Publications and source records attributed to F Murillo.

15 recordsLinked to original sources
PubMed1992

Epirubicin: clinical toxicity during the phase II program in endometrial and cervical cancer.

We have evaluated the clinical toxicity of Epirubicin 80 mg/m2 i.v., every 3 weeks in 58 patients with FIGO III-IV endometrial adenocarcinoma or squamous uterine cervix carcinoma. The median age of the whole group was 59 years (37-77); 37 patients were previously treated with radiotherapy and two with cisplatin based chemotherapy. The median KI at entry was 80. A total of 308 courses of chemotherapy were administered with a median of 5 per patient. Overall toxicity data shows that this dose level is associated with mild haematological toxicity with only two cases having grade 3 (WHO) leukopenia. Nine patients suffered emesis in spite of prophylactic therapy and were classified as grade 3. One case presented grade four diarrhoea but the relation with the antineoplastic treatment was uncertain. One woman with hepatic dysfunction at entry had grade 3 leukopenia, developed pneumonia and died. The median total cumulative dose of EPI was 360 mg/m2 (160-880) with 19 cases exposed to cumulative doses higher than 550 mg/m2. Congestive heart failure was not observed. Our data confirm the safety of EPI at these dose levels and suggest the possibility of developing new trials with higher doses of this anthracycline analog.

Adult↗
PubMed1991

The computerized Tower of Hanoi: a new form of administration and suggestions for interpretation.

A computerized version of the Tower of Hanoi with a new form of administration was administered to two different groups, 15 men and 22 women, who were university students reporting normal psychological histories, and 24 traumatically brain-injured patients (20 men and 4 women). Scores on this test for both groups can be interpreted as an index of ability to solve problems and of learning strategies. Men and women scored differently on the task, i.e., women used different strategies than men to solve problems.

Adolescent↗
PubMed1991

Single agent epirubicin in squamous cell cervical cancer. A phase II trial.

Thirty consecutive patients with FIGO stage III-IV, squamous cell uterine cervix cancer were entered in a phase II trial evaluating activity and safety of epirubicin when given at a dose of 80 mg/m2 i.v., every 3 weeks. Two complete responses (including a pathological complete remission) plus 3 partial responses were observed among 27 evaluable patients with a response rate of 18.5% (95% confidence limits = 7.6%-36.4%). The median time to progression and median survival for all treated patients were 3 and 8 months respectively. Treatment was well tolerated. Haematological toxicity was mild. WHO grade 4 toxicity was not observed. The median total cumulative dose of epirubicin was 360 mg/m2 (80-840 mg/m2). Congestive heart failure was not noted. Further studies in cervical cancer with higher doses of epirubicin as single agent or in combination with other nonmyelotoxic drugs are indicated.

Adult↗
PubMed1990

[Combined treatment of gaseous gangrene with hyperbaric oxygen therapy, surgery and antibiotics. A national cooperative multicenter study].

85 confirmed gas gangrene cases from general hospitals where hyperbaric oxygen chambers with single or multiple places are available were reviewed. The diagnosis was made on the basic of muscle necrosis with the characteristic color and odor of the wound, and suggestive clinical and bacteriological findings. The treatment consisted on surgical excision, multiple antibiotic therapy, and hyperbaric oxygen at 3 absolute atmospheres. There was a male predominance (76.5%); 49.4% of them had previous risk factors; the origin of the disease was spontaneous in 18.8% of cases, after trauma in 37.6%, and after surgery in 43.5%. The surgery had been orthopedic in 18.8%, vascular in 16.5% and other in 1.2%. The lesion was in the lower limbs in 71.8%, with abdominal origin of propagation in 18.8% and perineal propagation in 8.2%. 44.7% of patients had shock on admission. The outcome was good in 50.6% of patients, who had a full recovery, and fair in 16.5%, who had minor sequelae or small re-amputations; this amounts to 67.1% of satisfactory evolutions. Outcome was poor in 20% in whom amputation or other major surgical procedures were required (p less than 0.05). Overall mortality rate was 20%, although only in 12.9% death directly related with gas gangrene. Mortality was significantly higher in women, in abdominal localization, and in patients with shock. It was 37.5% in spontaneous and 29.7% in postsurgical cases. There was no death in traumatic cases (p less than 0.005). Death directly related with the disease occurred in the first three days and nonrelated death after two weeks. More severe cases could be cared for in hospitals where multiple place hyperbaric oxygen chambers were available than in those with single place chambers, with a definite outcome towards cure or death with less intermediate situations. The relevant literature is reviewed. It is concluded that this combined therapeutic schedule has the best efficacy to treat gas gangrene, particularly in the more severe forms.

Adolescent↗
PubMed1986

Amino acid absorption in jejunum of rats in vivo--a kinetic comparison of distal resection effects.

Jejunal absorption of leucine and cycloleucine by sham and 50% distal resected rats in vivo was studied by measuring the passive component and the active transport. After 5 months postresection the total amino acid absorption was increased. The mass-transfer coefficients of the passive process (obtained in presence of methionine) were higher in remnant jejunum than that in control rats, whereas the active transport remained unaltered after resection. When the kinetic constants of the saturable and non-saturable components were corrected for the unstirred water layer effects, the "real KD" increased in the resected group, whilst similar values for the "real Km and Jmax" were obtained.

Amino Acids↗
PubMed1986

Galactose transport across rat small intestine in vivo following distal resections of varying extents.

The kinetics of D-galactose absorption across rat small intestine in sham, 50 and 80% distal intestinal resected animals, have been studied under in vivo conditions. After 5 months post-resection the total galactose absorption was increased. The relationship between total absorption of substrate and its concentration in the perfusate showed a non-saturable component and a saturable one that can be inhibited by phloridzin, both in control and remnant intestine. The slope of the line that represents the non-saturable component is greater in remnant duodenum and jejunum, indicating that the apparent mass-transfer coefficient, K'D, was increased by distal resection. Non-linear fitting of the saturable component data gave an apparent maximal galactose transport rate (J'max, nmol/cm2 . min) of 134 +/- 13 (sham), 132 +/- 9 (50% resected), 139 +/- 9 (80% resected) in duodenum and of 103 +/- 11 (sham) and 106 +/- 12 in jejunum. Apparent Michaelis constants (K'm, mM) of 12.1 +/- 3.2 (sham), 12.3 +/- 2.2 (50% resected) and 13.3 +/- 2.2 (80% resected) in duodenum and of 11.6 +/- 3.7 (sham) and 12.8 +/- 3.7 (50% resected) in jejunum were found. Correction of the kinetic constants for the unstirred water layer (u.w.l.) effects showed that the differences between 'real' KD's of the experimental groups increased, whereas 'real' Km's did not significantly change. There were no significant differences in duodenal galactose absorption between 50 and 80% resected rats.

Animals↗
PubMed1978

The Aymara of Western Bolivia. II. Maxillofacial and dental arch variation.

Maxillofacial and dental arch dimensions of the Bolivian Aymara population are age and sex dependent. Interpopulational comparisons reveal these dimensions to differ from those seen in Aleuts, Australian aborigines, and Swedes, but to be similar to those of the indigenous Taiwanese. Finally, these dimensions are not the same in Aymara of unmixed ancestry, and Mestizos residing in the same villages.

Adolescent↗
PubMed1978

The Aymara of Western Bolivia. IV. Gene frequencies for eight blood groups and 19 protein and erythrocyte enzyme systems.

A total of 315 individuals, mainly of Aymara origin, from western Bolivia were examined for genetic variation at eight red cell antigen and 19 serum protein and red cell enzyme loci. The gene frequencies for polymorphic loci and the discovery of several rare variants are discussed in terms of previous work among the Aymara and the closely related Quechua. The effect of inclusion of related individuals in the sample on gene frequency, variance of gene frequency and genetic distance, is discussed.

Blood Group Antigens↗
PubMed1977

The Chipaya of Bolivia: Dermatoglyphics and ethnic relationships.

Dermatoglyphic data on 15 traits (digital arches, digital radial loops, digital ulnar loops, digital whorls, I loops, Ir loops, H loops, H loops, III loops, IV loops, mainline C absence, total ridge count, a-b ridge count, atd angle, and mainline index) are presented for 141 Chipaya Indians of Bolivia. Ethnic relationships of these Indians to nine South American Indian tribes (Alacaluf, Atacameño, Aymara, Cashinahua, Chácobo, Chama, Chané, Quechua, and Sirionó) are explored by means of a genetic distance analysis using 21 alleles. Genetic distances are complemented with linguistic and geographic distances between the Chipaya and the other tribes. Genetic distances were found not to be significantly correlated with linguistic and geographic distances. Combining the information available, it is concluded that the Chipaya are most likely ethnically related to the Arawak speakers of the tropical forest.

Bolivia↗
PubMed1976

High altitude, indigenous origin, and continuous cardiac monitoring.

Tape monitoring of the electrocardiogram among ambulant individuals with and without cardiac disease has been practicable for some years now. It has, however, found greater acceptance and utilization in diagnosis, early detection of silent ischemic heart disease (17), and the evaluation of the effectiveness of different dysrhythmia treatment modalities than as a means to examine differences in cardiovascular response to environmentally stressful situations. This study illustrates its practicability under field conditions substantially more rigorous than in most prior uses, and its applicability to our further understanding of the cardiovascular changes associated with adaptation to the hypoxia of altitude.

Adolescent↗
PubMedDate not supplied

[Visual constructive deficits and coma depth].

The present study has the purpose of relating the capacities of visual retention with the Benton Visual Retention Test and the level of coma depth, which is measured with the GCS (Glasgow Coma Scale). 31 subject suffering cranioencephalic damage admitted to the intensive care unit (ICU) have been studied. GCS scores were obtained during their stay in the intensive care unit and the Benton Visual Retention Test was administered after hospital discharge. The procedure followed consists in comparing the performance of subjects with higher GCS scores to subjects with lower values when executing administration. A of form C of BVRT. We could conclude as follows: firstly that BVRT is a useful tool to detect the existence of brain damage; secondly, indexes of brain damage presence with BVRT are: a low figure in correct design, more errors, less errors in distortion and rotation; more errors in the left visual hemifield. Thirdly, the depth of coma is a good prognosis index on BVRT execution and in consequence of visuo-constructive abilities.

Brain Injuries↗